12 research outputs found

    Concise Total Synthesis and Stereochemical Revision of (+)-Naseseazines A and B: Regioselective Arylative Dimerization of Diketopiperazine Alkaloids

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    Concise and enantioselective total syntheses of (+)-naseseazines A and B are described. Our regioselective and directed dimerization of diketopiperazines provides their critical C3–C[2 over sp] linkages, an assembly with plausible biogenetic relevance. We revise the absolute stereochemistry of (+)-naseseazines A and B.National Institute of General Medical Sciences (U.S.) (GM089732)Amgen Inc.DuPont (Firm)American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowshi
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