Teacher education in the UK in an era of performance management

In common with all education systems world wide, those of the United Kingdom have been subject to rapid change and development in recent years. Much of the management of this change has been supported by methods, including performance management of individuals, borrowed from industrial or commercial spheres of activity (Peters et al, 1999). This has led to a redefinition of concepts of teacher professionalism. In the two principal UK systems - those of England (often itself referred to as the UK system) and Scotland - there have been different emphases in terms of managing and developing the profession, although concerns of staff development and professional accountability are encapsulated in both. In this paper we argue, firstly, that staff development - of whatever variety - has to result in better learning for young people within schools. Secondly, we assert that the construction of teacher professionalism is a contested area in the UK, both in terms of initial teacher education and in terms of continuing professional development and that there has to be a recognition of this debate. Ultimately, however, both sides need to come together to create systems which support and develop pupil learning

Evidence for a Functional Interaction between Integrins and G Protein-activated Inward Rectifier K+ Channels

Heteromultimeric G protein-activated inward rectifier K+ (GIRK) channels, abundant in heart and brain, help to determine the cellular membrane potential as well as the frequency and duration of electrical impulses. The sequence arginine-glycine-aspartate (RGD), located extracellularly between the first membrane-spanning region and the pore, is conserved among all identified GIRK subunits but is not found in the extracellular domain of any other cloned K+ channels. Many integrins, which, like channels, are integral membrane proteins, recognize this RGD sequence on other proteins, usually in the extracellular matrix. We therefore asked whether GIRK activity might be regulated by direct interaction with integrin. Here, we present evidence that mutation of the RGD site to RGE, particularly on the GIRK4 subunit, decreases or abolishes GIRK current. Furthermore, wild-type channels can be co-immunoprecipitated with integrin. The total cellular amount of expressed mutant GIRK channel protein is the same as the wild-type protein; however, the amount of mutant channel protein that localizes to the plasma membrane is decreased relative to wild-type, most likely accounting for the diminished GIRK current detected. GIRK channels appear to bind directly to integrin and to require this interaction for proper GIRK channel membrane localization and function

Single-shooting homotopy method for parameter identification in dynamical systems

An algorithm for identifying parameters in dynamical systems is developed in this work using homotopy transformations and the single-shooting method. The equations governing the dynamics of the mathematical model are augmented with observer-like homotopy terms that smooth the objective function. As a result, premature convergence to a local minimum is avoided and the obtained parameter estimates are globally optimal. Numerical examples are presented to demonstrate the application of the proposed approach to chaotic systems

The Formation of the Double Pulsar PSR J0737-3039A/B

Recent timing observations of the double pulsar J0737-3039A/B have shown that its transverse velocity is extremely low, only 10 km/s, and nearly in the Plane of the Galaxy. With this new information, we rigorously re-examine the history and formation of this system, determining estimates of the pre-supernova companion mass, supernova kick and misalignment angle between the pre- and post-supernova orbital planes. We find that the progenitor to the recently formed `B' pulsar was probably less than 2 MSun, lending credence to suggestions that this object may not have formed in a normal supernova involving the collapse of an iron core. At the same time, the supernova kick was likely non-zero. A comparison to the history of the double-neutron-star binary B1534+12 suggests a range of possible parameters for the progenitors of these systems, which should be taken into account in future binary population syntheses and in predictions of the rate and spatial distribution of short gamma-ray burst events.Comment: To appear in MNRAS Letters. Title typo fix only; no change to pape

Building Capacity in Nonprofit Organizations

Offers a capacity building model that is based on a review of civil society, sustainable development, and organizational management literature. Reviews effective capacity building programs sponsored or operated by foundations. Includes recommendations

Editorial: Transdisciplinary Innovation

This special issue includes a rich and nuanced set of takeaways for practitioners, academics, and members of the public or third sectors. We highlight four of them here, regarding learning, spaces, levels of impact, and partner selection. We nonetheless strongly encourage you to read the entire set of articles to make sure you get a balanced overview of different ways in which transdisciplinary innovation occurs

Inhibition of release of inflammatory in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis

BACKGROUND - We demonstrated that a Chinese herbal formula, which we refer to as RCM-101, developed from a traditional Chinese medicine formula, reduced nasal and non-nasal symptoms of seasonal allergic rhinitis (SAR). The present study in primary and cultured cells was undertaken to investigate the effects of RCM-101 on the production/release of inflammatory mediators known to be involved in SAR. METHODS - Compound 48/80-induced histamine release was studied in rat peritoneal mast cells. Production of leukotriene B4 induced by the calcium ionophore A23187 was studied in porcine neutrophils using an HPLC assay and lipopolysaccharide-stimulated prostaglandin E2 production was studied in murine macrophage (Raw 264.7) cells by immune-enzyme assay. Expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) was determined in Raw 264.7 cells, using western blotting techniques. RESULTS - RCM-101 (1-100 microg/mL) produced concentration-dependent inhibition of compound 48/80-induced histamine release from rat peritoneal mast cells and of lipopolysaccharide-stimulated prostaglandin E2 release from Raw 264.7 cells. Over the range 1 - 10 microg/mL, it inhibited A23187-induced leukotriene B4 production in porcine neutrophils. In addition, RCM-101 (100 microg/mL) inhibited the expression of COX-2 protein but did not affect that of COX-1. CONCLUSION - The findings indicate that RCM-101 inhibits the release and/or synthesis of histamine, leukotriene B4 and prostaglandin E2 in cultured cells. These interactions of RCM-101 with multiple inflammatory mediators are likely to be related to its ability to reduce symptoms of allergic rhinitis

Results-Based Organization Design for Technology Entrepreneurs

Faced with considerable uncertainty, entrepreneurs would benefit from clearly defined objectives, a plan to achieve these objectives (including a reasonable expectation that this plan will work), as well as a means to measure progress and make requisite course corrections. In this article, the author combines the benefits of results-based management with the benefits of organization design to describe a practical approach that technology entrepreneurs can use to design their organizations so that they deliver desired outcomes. This approach links insights from theory and practice, builds logical connections between entrepreneurial activities and desired outcomes, and measures progress toward those outcomes. This approach also provides a mechanism for entrepreneurs to make continual adjustments and improvements to their design and direction in response to data, customer and stakeholder feedback, and changes in their business environment