Dressing Cosets

The account of the Poisson-Lie T-duality is presented for the case when the action of the duality group on a target is not free. At the same time a generalization of the picture is given when the duality group does not even act on \si-model targets but only on their phase spaces. The outcome is a huge class of dualizable targets generically having no local isometries or Poisson-Lie symmetries whatsoever.Comment: 11 pages, LaTe

Open Strings and D-branes in WZNW model

An abundance of the Poisson-Lie symmetries of the WZNW models is uncovered. They give rise, via the Poisson-Lie $T$-duality, to a rich structure of the dual pairs of $D$-branes configurations in group manifolds. The $D$-branes are characterized by their shapes and certain two-forms living on them. The WZNW path integral for the interacting $D$-branes diagrams is unambiguously defined if the two-form on the $D$-brane and the WZNW three-form on the group form an integer-valued cocycle in the relative singular cohomology of the group manifold with respect to its $D$-brane submanifold. An example of the $SU(N)$ WZNW model is studied in some detail.Comment: 28 pages, LaTe

Estudio de digénidos de peces marinos del sur de la Península Ibérica

Se han estudiado un total de 492 hospedadores pertenecientes a 72 especies de peces marinos, todos procedentes de la plataforma continental que bordea el sur de la Península Ibérica. Como resultado de este trabajo se han localizado en el aparato digestivo de estos hospedadores 39 especies de Digenea. De ellas, Stephanostomum bicoronatum, (Stossich, 1883) Manter, 1940, Parahemiurus merus, (Linton, 1910) Manter, 1940, Derogenes latus Janiszewska, 1953, Bacciger israelensis Fischtha1, 1980, Promnoprymna ventricosa (Rudolphi, 1819) Poche, 1926, Haploporus benedenii (Stossich, 1887) Looss, 1902, Haplosplanchnus pachysomus (Eysenhardt, 1829) Looss, 1902, Saccocoelium obesum Looss, 1902, y Genolopa ampullacea Linton, 1910 se citan por primera vez en la península Ibérica. Lecithochirium musculus (Looss, 1907) Nasir y Díaz, 1971, Lecithochirium rufoviride (Rudolphi, 1819) Lühe, 1901, Lecithochirium fusiforme Lühe, 1901, Ectenurus lepidus Looss, 1907 y Tergestia laticollis (Rudolphi, 1819) Stossich, 1899, en las costas de Andalucia. Stephanostomum minutum en el Mediterráneo peninsular. Wardulla capitel/ata (Rudolphi, 1819) Poche, 1926 y Deropristis inflata en el Atlántico peninsular. Además, con el presente trabajo se amplía considerablemente el espectro de hospedadores de algunas de las especies parásitas estudiadas. Así Halobatrachus didactylus es nuevo hospedador para Stephanostomum minutum (Looss, 1901) Manter, 1940, Anisocladium fallax (Rudolphi, 1819) Looss, 1902 y Anisocoelium capitellatum (Rudolphi, 1819) Lühe, 1900. Bothus podas para Lecithocladium excisum (Rudolphi, 1819) Lühe, 1901 y Derogenes varicus (Müller, 1784) Looss, 1901. Solea sp. para Lecithochirium musculus (Looss, 1907) Nasir y Díaz, 1971. Trachinotus ovatus para Synaptobothrium caudiporum (Rudolphi, 1819) Looss, 1907. Scorpaena scrofa para Derogenes latus Janiszewska, 1953. Belone belone para Tergestia laticollis (Rudolphi, 1819) Stossich, 1899. Dicentrarchus punctatus para Acanthostomum imbutiforme (Molin, 1859) Gohar, 1934 y Bucephalus baeri Maillard, 1976. y Echiichthys vipera para Anisocladiumfallax (Rudolphi, 1819) Looss, 1902 y Anisocoelium capitellatum (Rudolphi, 1819) Lühe, 1900A total of 492 host of72 diferent species ofmarine fishes were colleted from the Sourth Iberian Peninsula coast and their tract digest were examined. We have identified 39 species ofDigenea. Stephanostomum bicoronatum, (Stossich, 1883) Manter, 1940, Parahemiurus merus, (Linton, 1910) Manter, 1940, Derogenes latus Janiszewska, 1953, Bacciger israelensis Fischthal, 1980, Promnoprymna ventricosa (Rudolphi, 1819) Po che, 1926, Haploporus benedenii (Stossich, 1887) Looss, 1902, Haplosplanchnus pachysomus (Eysenhardt, 1829) Looss, 1902, Saccocoelium obesum Looss, 1902, and Genolopa ampullacea Linton, 1910, have not previously been reported from Iberian Peninsula. Furthermore, Lecithochirium musculus (Looss, 1907) Nasir y Díaz, 1971, Lecithochirium rufoviride (Rudolphi, 1819) Lühe, 1901, Lecithochirium fusiforme Lühe, 1901, Ectenurus lepidus Looss, 1907 and Tergestia laticollis (Rudolphi, 1819) Stossich, 1899, are reported for the first time in Andalucian coast; Stephanostomum minutum in the spanish mediterranean coast and finally, Wardulla capitellata (Rudolphi, 1819) Poche, 1926 and Deropristis inflata in the Atlántic peninsular. In this paper, we have thoroughly widened the host range for sorne of the species here studied. So, Halobatrachus didactylus is a new host for Stephanostomum minutum (Looss, 1901) Manter, 1940, Anisocladiumfallax (Rudolphi, 1819) Looss, 1902 and Anisocoelium capitellatum (Rudolphi, 1819) Lühe, 1900. Bothus podas for Lecithocladium excisum (Rudolphi, 1819) Lühe, 1901 and Derogenes varicus (Müller, 1784) Looss, 1901. Solea sp. for Lecithochirium musculus (Looss, 1907) Nasir y Díaz, 1971. Trachinotus ova tus for Synaptobothrium caudiporum (Rudolphi, 1819) Looss, 1907. Scorpaena scrofa for Derogenes latus Janiszewska, 1953. Belone belone for Tergestia laticollis (Rudolphi, 1819) Stossich, 1899. Dicentrarchus punctatus for Acanthostomum imbutiforme (Molin, 1859) Gohar, 1934 and Bucephalus baeri Maillard, 1976. Echiichthys vipera for Anisocladiumfallax (Rudolphi, 1819) Looss, 1902 andAnisocoelium capitellatum (Rudolphi, 1819) Lühe, 190

Poisson-Lie T-duality: Open Strings and D-branes

Global issues of the Poisson-Lie T-duality are addressed. It is shown that oriented open strings propagating on a group manifold $G$ are dual to $D$-brane - anti-$D$-brane pairs propagating on the dual group manifold \ti G. The $D$-branes coincide with the symplectic leaves of the standard Poisson structure induced on the dual group \ti G by the dressing action of the group $G$. T-duality maps the momentum of the open string into the mutual distance of the $D$-branes in the pair. The whole picture is then extended to the full modular space $M(D)$ of the Poisson-Lie equivalent \si-models which is the space of all Manin triples of a given Drinfeld double.T-duality rotates the zero modes of pairs of $D$-branes living on targets belonging to $M(D)$. In this more general case the $D$-branes are preimages of symplectic leaves in certain Poisson homogeneous spaces of their targets and, as such, they are either all even or all odd dimensional.Comment: 15 pages, LaTeX (references added

Measurement of the radiative neutron capture cross section of 206 Pb and its astrophysical implications

The (n,γ) cross section of 206Pb has been measured at the CERN n_TOF facility with high resolution in the energy range from 1 eV to 620 keV by using two optimized 6C6D detectors. In the investigated energy interval about 130 resonances could be observed, from which 61 had enough statistics to be reliably analyzed via the R-matrix analysis code SAMMY. Experimental uncertainties were minimized, in particular with respect to (i) angular distribution effects of the prompt capture γ-rays, and to (ii) the TOF-dependent background due to sample-scattered neutrons. Other background components were addressed by background measurements with an enriched 208Pb sample. The effect of the lower energy cutoff in the pulse height spectra of the 6C6D detectors was carefully corrected via Monte Carlo simulations. Compared to previous 206Pb values, the Maxwellian averaged capture cross sections derived from these data are about 20% and 9% lower at thermal energies of 5 keV and 30 keV, respectively. These new results have a direct impact on the s-process abundance of 206Pb, which represents an important test for the interpretation of the cosmic clock based on the decay of 238U

Substitution at the indole 3 position yields highly potent indolecombretastatins with reduced susceptibility to MDR resistance

[EN]Resistance to combretastatin A-4 is mediated by metabolic modification of the phenolic hydroxyl and ether groups of the 3-hydroxy-4-methoxyphenyl (B ring). Replacement of the B ring of combretastatin A-4 by a N-methyl-5-indolyl reduces tubulin polymerization inhibition (TPI) and cytotoxicity against human cancer cell lines but cyano, methoxycarbonyl, formyl, and hydroxyiminomethyl substitutions at the indole 3-position restores potent TPI and cytotoxicity against sensitive human cancer cell lines. These highly potent substituted derivatives displayed low nanomolar cytotoxicity against several human cancer cell lines due to tubulin inhibition, as shown by cell cycle analysis, confocal microscopy, and tubulin polymerization inhibitory activity studies and promoted cell killing mediated by caspase-3 activation. Binding at the colchicine site was suggested by molecular modeling studies. Substituted combretastatins displayed higher potencies than the isomeric isocombretastatins and the highest potencies were achieved for the hydroxyiminomethyl (21) and cyano (23) groups, with TPI values in the submicromolar range and cytotoxicities in the subnanomolar range. Dose-response and time-course studies showed that drug concentrations as low as 1 nM (23) or 10 nM (21) led to a complete G2/M cell cycle arrest after 15 h treatment followed by a high apoptosis-like cell § These authors contributed equally to this work. 3 response after 48-72 h treatment. The P-glycoprotein and calcium antagonist verapamil increased 21 and 23 cytotoxicity to IC50 values of 10-10 M, and highly potentiated the cytotoxic activity in 100-fold of the CHO derivative (17), in A549 human non-small cell lung cancer cells. The differences in cytotoxic potency observed between the highly potent cyano (23) and hydroxyiminomethyl (21) groups and other substituents with similar TPI values (17) were very much reduced upon co-treatment with verapamil. A 3,4,5-trimethoxyphenyl ring always afforded more potent derivatives than a 2,3,4-trimethoxyphenyl ring

Generación, análisis y visualización de estructuras tridimensionales de complejos fármaco-diana para la docencia teórica y práctica del diseño de fármacos

Memoria ID-127. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2019-2020

Search of dark-matter axions in the microwave frequency range with full-wave modal techniques

Axions, originally proposed to solve the strong Charge-Parity problem of Quantum Chromo-Dynamics theory, emerge now as leading candidates of dark matter. In fact, the search of dark-matter axions in the microwave frequency range has been developed by different research groups during the last twenty years. In this demanding scenario, several microwave passive components (haloscopes) have been designed and fabricated for such axions detection based on the use of cavities and multi-cavities. From an electromagnetic point of view, comercial software (ANSFT HFSS, CST MICROWAVE STUDIO, etc ) has been employed for the design of different kind of haloscopes. In this work we propose to use the BI-RME 3D method (Boundary Integral – Resonant Mode Expansion) as an alternative to analyze the axion-photon coupling existing within an haloscope. This full-wave modal technique has provided interesting wide-band results for the design of new haloscopes

A comparison of five DNA extraction methods from degraded human skeletal remains

Extracting DNA from degraded human remains poses a challenge for any forensic genetics laboratory, as it requires efficient high-throughput methods. While little research has compared different techniques, silica in suspension has been identified in the literature as the best method for recovering small fragments, which are often present in these types of samples. In this study, we tested five DNA extraction protocols on 25 different degraded skeletal remains. Including the humerus, ulna, tibia, femur, and petrous bone. The five protocols were organic extraction by phenol/chloroform/isoamyl alcohol, silica in suspension, High Pure Nucleic Acid Large Volume silica columns (Roche), InnoXtract™ Bone (InnoGenomics), and PrepFiler™ BTA with AutoMate™ Express robot (ThermoFisher). We analysed five DNA quantification parameters (small human target quantity, large human target quantity, human male target quantity, degradation index, and internal PCR control threshold), and five DNA profile parameters (number of alleles with peak height higher than analytic and stochastic threshold, average relative fluorescence units (RFU), heterozygous balance, and number of reportable loci) were analysed. Our results suggest that organic extraction by phenol/chloroform/ isoamyl alcohol was the best performing method in terms of both quantification and DNA profile results. However, Roche silica columns were found to be the most efficient method