Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis

Background: Tea consumption is associated with a lower risk of cardiovascular disease including stroke. Direct effects of tea components on the vasculature, particularly the endothelium, may partly explain this association. Objective: We performed a meta-analysis of controlled human intervention studies on the effect of tea on flow-mediated dilation (FMD) of the brachial artery, a measurement of endothelial function, which is suggested to be associated with cardiovascular risk. Methods: Human intervention studies were identified by systematic search of the databases Medline, Embase, Chemical Abstracts and Biosis through March 2009 and by hand-searching related articles. Studies were selected based on predefined criteria: intervention with tea as the sole experimental variable, placebo-controlled design, and no missing data on FMD outcome or its variability. A random effects model was used to calculate the pooled overall effect on FMD due to the intake of tea. The impact of various subject and treatment characteristics was investigated in the presence of heterogeneity. Results: In total, 9 studies from different research groups were included with 15 relevant study arms. The overall absolute increase in FMD of tea vs. placebo was 2.6 % of the arterial diameter (95 % CI: 1.8-3.3%; P-value,0.001) for a median daily dose of 500 mL of tea (2–3 cups). This is a relative increase of approximately 40 % compared to the average FMD of 6.3% measured under placebo or baseline conditions. There was significant heterogeneity between studies (P-value,0.001) tha

Revisiting the measurement of absolute foil-separation for RDDS measurements and introduction of an optical measurement method

Uncertainties in absolute plunger distances are an often overlooked component in measurements with the Recoil Distance Doppler-shift (RDDS) method when the Differential Decay Curve (DDC) method cannot be used for the analysis. It is shown how these uncertainties arise when the capacitance method is used to determine absolute distances and how they influence the obtained lifetime values of a plunger experiment. Furthermore, a new approach to obtain absolute foil separations for plunger measurements using a high precision optical distance probe is introduced, which can reduce these uncertainties by a large margin. The performance of this method is demonstrated by comparisons to the capacitance method as well as to a precise measurement of absolute distances using known lifetimes in 181Ta