Scotland’s beginnings: Scotland through time.

Did you know that Scotland began under an iceberg-laden sea near the South Pole hundreds of millions of years ago? The journey north of the land we now call Scotland is an astounding tale of great mountains, subtropical rainforests, coral reefs, howling deserts, ammonite-inhabited seas, high lava plateaus and scouring ice caps. The evidence for this journey is recorded in rocks, peat-bogs and lake muds. When the glaciers withdrew the new land was colonised by animals and plants but when hunters and farmers moved in mass extinction began. This beautifully illustrated guide, full of drawings, paintings and photographs, is an excellent introduction to Scotland’s earliest history

Missing mammals from the Mesolithic middens: a comparison of the fossil and archaeological records from Scotland

Wild mammmals were an essential source of food and materials for Mesolithic people in Scotland. However, most Mesolithic sites in Scotland contain scant evidence of the mammals that were exploited locally. In contrast, the fossil and contemporary records indicate that there was a very high and changing diversity of mammal species available to Mesolithic hunter-gatherers as the climate warmed at the end of the last Ice Age: up to 23 species of terrestrial and freshwater mammals from the fossil record compared to a maximum of 16 species from Mesolithic sites, but only four of these were found at more than two sites. The reasons for this disparity between the fossil and the archaeological records are discussed. In Scotland most Mesolithic sites with faunal remains are coastal shell middens, which may not be sites where mammals were routinely hunted and their carcasses processed. The shell midden sites are also of Later Mesolithic date and hence cannot reflect the Early Holocene fauna, which included cold climate species that had survived from the Lateglacial. Many areas have acid soils in which bones are only rarely preserved, and this may explain the absence of faunal materials from the majority of coastal and inland sites. The fact that larger mammals may have been processed at the kill sites, and that some mammals were exploited for their skins, futher reduces the chances of their survival in the archaeological record. Finally, optimal foraging for prey in relation to prey density may have meant that some large mammal species (e.g. moose) were not worth hunting except opportunistically. It is likely that all of these factors have contributed to the impoverished mammal fauna of the Scottish Mesolithic

Harmful and Helpful Therapy Practices with Consensually Non-Monogamous Clients: Toward an Inclusive Framework

Drawing on minority stress perspectives, we investigated the therapy experiences of individuals in consensually nonmonogamous (CNM) relationships. Method: We recruited a community sample of 249 individuals engaged in CNM relationships across the U.S. and Canada. Confirmatory factor analysis structural equation modeling was used to analyze client perceptions of therapist practices in a number of exemplary practices (affirming of CNM) or inappropriate practices (biased, inadequate, or not affirming of CNM), and their associations with evaluations of therapy. Open-end responses about what clients found very helpful and very unhelpful were also analyzed. Results: Exemplary and inappropriate practices constituted separate but related patterns of therapist conduct. As expected, perceptions of exemplary and inappropriate practices predicted therapist helpfulness ratings and whether participants prematurely terminated their therapeutic relationships. Qualitative results point toward the importance of having/pursuing knowledge about CNM and using affirming, nonjudgmental practices. Conclusions: Therapists are positioned to either combat or perpetuate the minority stress faced by individuals engaged in CNM. The results of this study highlight the need for additional research, training, and guidelines regarding CNM clients and their therapy experiences

A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: extended follow up in the ARTISTIC trial.

BACKGROUND: The additional sensitivity of HPV testing compared with cytology could permit extended cervical screening intervals. We wished to determine, through a further (third) round of screening in the ARTISTIC trial, the protection provided by a negative baseline HPV screen compared with that of cytology over a 6 year period. METHODS: Cumulative rates of CIN2 or worse (CIN2+) and CIN3 or worse (CIN3+) were correlated with baseline HPV status and cytology. HPV was detected using the Hybrid Capture 2 (Qiagen) assay for high risk types and genotyped using the Linear Array (Roche) and Papillocheck (Greiner) assays. LBC was performed using ThinPrep (Hologic). FINDINGS: Round 3 included 8,873 women of whom 6,337 had been screened in both rounds 1 and 2 and 2,536 had not been screened since round 1. The median duration of follow-up was 72.7 months. The cumulative rate of CIN2+ over three rounds was 3.88% (95%CI 3.59%, 4.17%) overall; 2.39% in round 1, 0.78% in round 2 and 0.74% in round 3. Cumulative rates by baseline status were 20.53% (95%CI 19.04%, 22.08%) for abnormal cytology, 20.12% (95%CI 18.68%, 21.61%) for HPV detection, 1.41% (95%CI 1.19%, 1.65%) for negative cytology and 0.87% (95%CI 0.70%, 1.06%) for a negative HPV test. In HPV negative women aged over 50 the cumulative rate was 0.16% (95%CI 0.07%, 0.34%). Women who were HPV positive/cytology negative at entry had a cumulative CIN2+ rate of 7.73% (95%CI 6.29%, 9.36%) over 6 years, twice the overall rate. INTERPRETATION: A negative HPV test was significantly more protective than normal cytology over three rounds. The findings of this extension of ARTISTIC suggest that the screening interval could be extended to 6 years if HPV testing replaced cytology as the primary screening test

Reconstructing Mammalian Phylogenies: A Detailed Comparison of the Cytochrome b and Cytochrome Oxidase Subunit I Mitochondrial Genes

The phylogeny and taxonomy of mammalian species were originally based upon shared or derived morphological characteristics. However, genetic analyses have more recently played an increasingly important role in confirming existing or establishing often radically different mammalian groupings and phylogenies. The two most commonly used genetic loci in species identification are the cytochrome oxidase I gene (COI) and the cytochrome b gene (cyt b). For the first time this study provides a detailed comparison of the effectiveness of these two loci in reconstructing the phylogeny of mammals at different levels of the taxonomic hierarchy in order to provide a basis for standardizing methodologies in the future. Interspecific and intraspecific variation is assessed and for the first time, to our knowledge, statistical confidence is applied to sequence comparisons. Comparison of the DNA sequences of 217 mammalian species reveals that cyt b more accurately reconstructs their phylogeny and known relationships between species based on other molecular and morphological analyses at Super Order, Order, Family and generic levels. Cyt b correctly assigned 95.85% of mammal species to Super Order, 94.31% to Order and 98.16% to Family compared to 78.34%, 93.36% and 96.93% respectively for COI. Cyt b also gives better resolution when separating species based on sequence data. Using a Kimura 2-parameter p-distance (x100) threshold of 1.5–2.5, cyt b gives a better resolution for separating species with a lower false positive rate and higher positive predictive value than those of COI