Designing for dementia: Iterative grief and transitional objects

© 2018 Massachusetts Institute of Technology. Designers increasingly are exploring how to support individuals transitioning through loss and grief and coming to terms with a loved one’s death. For people living with dementia and their families, the loss and grief they experience is iterative and ongoing. This paper discusses design research to make sensory textile objects for people with advanced dementia, intended to support positive well-being, shared experiences, and “in the moment” pleasure. It draws on theories relating to transitional and transformational objects to show how these textiles support those living with dementia as they transition into greater dependency and move toward the end of life. It shows how, after their death, the objects become memorials and symbolic representations, further supporting family members through their experience of loss

Conversations at the edge of play: media, communication and cultural intersections with dementia

© 2017 Informa UK Limited, trading as Taylor & Francis Group. The mean age of the global population is increasing significantly. Incidences of dementia are also predicted to rise and this will impact society as a whole as well as individuals, who will find they are primary carers for one or more family members with the disease. Dementia carries a stigma and is not openly discussed. Discourse continues to be led by bio-medical approaches that focus on the need to ‘fight’ the disease and often leaves individuals feeling ill-prepared and powerless to act. This paper reports on an innovative approach that engages with material culture production; it uses textiles as media to encourage people to share their personal experiences of dementia. The pilot project involved the general public in the making of bespoke sensory objects to promote ‘in the moment pleasure’ for people with later stage dementia, while facilitating an exchange of information about dementia both formally and informally with participants engaged in the making process. The study found that while participants’ individual knowledge and understanding of dementia varied significantly, each participant was able to contribute, share their knowledge and become empowered through activity

Nucleate pool boiling investigation on a silicon test section with micro-fabricated cavities

The basic mechanisms of nucleate boiling are still not completely understood, in spite of the many numerical and experimental studies dedicated to the topic. The use of a hybrid code allows reasonable computational times for simulations of a solid plate with a large population of artificial micro-cavities with fixed distribution. This paper analyses the guidelines for the design, through numerical simulations, of the location and sizes of micro-fabricated cavities on a new silicon test section immersed in FC-72 at the saturation temperature for different pressures with an imposed heat flux applied at the back of the plate. Particular focus is on variations of wall temperature around nucleation sites

Experimental pool boiling investigations of vertical coalescence for FC-72 on silicon from an isolated artificial cavity

In this study bubble growth from an isolated artificial cavity micro-fabricated on a horizontal 380 µm thick silicon wafer was investigated. The horizontally oriented boiling surface was heated by a thin resistance heater integrated on the rear of the silicon test section. The temperature was measured using an integrated micro-sensor situated on the boiling surface with the artificial cavity located in its geometrical centre. A resistive track was used as the sensor, which when calibrated, exhibited a near-linear behaviour with increasing temperature. To conduct pool boiling experiments the test section was immersed in degassed fluorinert FC-72. Bubble nucleation, growth and detachment at different pressures were observed using high-speed imaging. Coalescence was observed at the boundary between the isolated bubble and interference regimes. The occurrence of vertical coalescence was found to be more frequent, with increasing wall superheat and decreasing pressure. The equivalent sphere volumes of two bubbles before and after coalescence were evaluated from area measurements. It was observed that the second nucleated bubble is always smaller than its predecessor. The vapour generation appears not to stop during coalescence as the volume of the merged bubble was typically 5-18% larger than the sum of the bubble volumes just before coalescence

Steps towards the development of an experimentally verified simulation of pool nucleate boiling on a silicon wafer with artificial sites

Nucleate boiling is a very effective heat transfer cooling process, used in numerous industrial applications. Despite intensive research over decades, a reliable model of nucleate pool boiling is still not available. This paper presents a numerical and experimental investigation of nucleate boiling from artificial nucleation sites. The numerical investigation described in the first section of the paper is carried out by a hybrid mechanistic numerical code first developed at the University of Ljubljana to simulate the temperature field in a heated stainless steel plate with a large number of nucleation sites during pool boiling of water at atmospheric pressure. It is now being redeveloped to interpret experiments on pool boiling at artificial sites on a silicon plate and as a design tool to investigate different arrangements of sites to achieve high heat fluxes. The code combines full simulation of the temperature field in the solid wall with simplified models or correlations for processes in the liquid-vapour region. The current capabilities and limitations of the code are reviewed and improvements are discussed. Examples are given of the removal of computational constraints on the activation of sites in close proximity and improvements to the bubble growth model. Preliminary simulations are presented to compare the wall conditions to be used in the experiments on silicon at Edinburgh University with the conditions in current experiments on thin metal foils at Ljubljana. An experimental rig for boiling experiments with artificial cavities on a 0.38 mm thick silicon wafer immersed in FC-72, developed at Edinburgh University, is described in the second part of the paper

Simulation and experimental investigation of pool boiling on a silicon wafer with artificial nucleation sites

This paper reports progress on a project to develop a design tool for large arrays of nucleation sites at specified locations to achieve high rates of cooling by pool boiling. The tool will be based on an improved version of a hybrid simulation, in which the 3-D temperature field in the wall is solved numerically, along with simple sub-models for bubble-driven heat transfer that require experimental calibration. Improvements to the computer code and progress with the experiments are reported briefly. The paper focuses on the development of a sub-model for the lateral coalescence of bubbles, which is shown to cause irregularity in the bubble production by a regular array of nucleation sites

The potential for using a Universal Medication Schedule (UMS) to improve adherence in patients taking multiple medications in the UK: a qualitative evaluation

BACKGROUND: Poor adherence to prescribed medication has major consequences. Managing multiple long-term conditions often involves polypharmacy, potentially increasing complexity and the possibility of poor adherence. As a result of the globally recognised problems in supporting adherence to medication, some researchers have proposed the use of reminder charts. The main aim of the research was to explore the need for and perceptions around the 'Universal Medication Schedule' (UMS). Looking at ways in which pharmacists and General Practitioners (GPs) could use the UMS in NHS settings. METHODS: Semi-structured interviews were carried out with 10 GPs, 10 community pharmacists and 15 patients. Patients were aged 65 years and over, had multiple long-term conditions and were prescribed at least 5 medications. Interviews were recorded and transcribed and thematic analysis was conducted, using a framework approach to manage the data. RESULTS: Attitudes towards the UMS were mixed with stakeholders seeing benefits and limitations to the chart. Practitioners proposed a number of existing services where they thought the UMS could easily be integrated but there was evidence of role conflict with GPs feeling it may be best placed with pharmacists and vice versa. The potential for the UMS to be used as a tool to aid communication between the different services involved in a patient's care was a key theme. CONCLUSIONS: The UMS chart provides consolidated medicines information that might help to improve patients' knowledge and health literacy, which may or may not improve adherence but could help patients in making informed decisions about their treatment. One of the key benefits of using the UMS in practice is that it could be introduced across services. In this way it may aid in medicines reconciliation between healthcare settings to ensure continuity of message, improve patient experience and create more joined up working between services. Further research is needed to test implementation in different services and to assess outcomes on patient understanding and adherence

Full Aging in Spin Glasses

The discovery of memory effects in the magnetization decays of spin glasses in 1983 began a large effort to determine the exact nature of the decay. While qualitative arguments have suggested that the decay functions should scale as $t_{w}$, the only time scale in the system, this type of scaling has not yet been observed. In this letter we report strong evidence for the scaling of the TRM magnetization decays as a function of $t_{w}$. By varying the rate and the profile that the sample is cooled through its transition temperature to the measuring temperature, we find that the cooling plays a major role in determining scaling. As the effective cooling time decreases, $\frac {t}{t_{w}}$scaling improves and for $t_{c}^{eff}<20s$ we find almost perfect $\frac{t}{t_{w}}$ scaling. We also find that subtraction of a stationary term from the magnetization decay has a small effect on the scaling but changes the form of the magnetization decay and improves overlap between curves produced with different $t_{w}$.Comment: 4 pages, 3 figure

Thermally Activated Magnetization and Resistance Decay during Near Ambient Temperature Aging of Co Nanoflakes in a Confining Semi-metallic Environment

We report the observation of magnetic and resistive aging in a self assembled nanoparticle system produced in a multilayer Co/Sb sandwich. The aging decays are characterized by an initial slow decay followed by a more rapid decay in both the magnetization and resistance. The decays are large accounting for almost 70% of the magnetization and almost 40% of the resistance for samples deposited at 35 $^oC$. For samples deposited at 50 $^oC$ the magnetization decay accounts for $\sim 50$ of the magnetization and 50% of the resistance. During the more rapid part of the decay, the concavity of the slope of the decay changes sign and this inflection point can be used to provide a characteristic time. The characteristic time is strongly and systematically temperature dependent, ranging from $\sim1$x$10^2 s$ at 400K to $\sim3$x$10^5 s$ at 320K in samples deposited at $35 ^oC$. Samples deposited at 50 $^oC$ displayed a 7-8 fold increase in the characteristic time (compared to the $35 ^oC$ samples) for a given aging temperature, indicating that this timescale may be tunable. Both the temperature scale and time scales are in potentially useful regimes. Pre-Aging, Scanning Tunneling Microscopy (STM) reveals that the Co forms in nanoscale flakes. During aging the nanoflakes melt and migrate into each other in an anisotropic fashion forming elongated Co nanowires. This aging behavior occurs within a confined environment of the enveloping Sb layers. The relationship between the characteristic time and aging temperature fits an Arrhenius law indicating activated dynamics

OCT-4 expression in follicular and luteal phase endometrium: a pilot study

<p>Abstract</p> <p>Background</p> <p>The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date.</p> <p>Methods</p> <p>In a prospective, single center cohort study of 98 women undergoing hysteroscopy during the follicular (n = 49) and the luteal (n = 40) phases of the menstrual cycle, we obtained endometrial samples. Specimens were investigated for OCT-4 expression on the mRNA and protein levels using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Expression of OCT-4 was correlated to menstrual cycle phase.</p> <p>Results</p> <p>Of 89 women sampled, 49 were in the follicular phase and 40 were in the luteal phase. OCT-4 mRNA was detected in all samples. Increased OCT-4 mRNA levels in the follicular and luteal phases was found in 35/49 (71%) and 27/40 (68%) of women, respectively (p = 0.9). Increased expression of OCT-4 protein was identified in 56/89 (63%) samples. Increased expression of OCT-4 protein in the follicular and luteal phases was found in 33/49 (67%) and 23/40 (58%) of women, respectively (p = 0.5).</p> <p>Conclusions</p> <p>On the mRNA and protein levels, OCT-4 is not differentially expressed during the menstrual cycle. Endometrial OCT-4 is not involved in or modulated by hormone-induced cyclical changes of the endometrium.</p