55 research outputs found
Characterization of the Bafilomycin Biosynthetic Gene Cluster from Streptomyces lohii
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96305/1/301_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/96305/2/cbic_201200743_sm_miscellaneous_information.pd
Hyperelastic, shapeâmemorable, and ultraâcellâadhesive degradable polycaprolactoneâpolyurethane copolymer for tissue regeneration
Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity,
shape-memory, and ultra-cell-adhesion properties are reported as clinically
applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxylated
or ethoxylated ones) were developed to improve mechanical properties by enhanced
reactivity in copolymer synthesis compared to the original isosorbide. Optimized
PCL-PU with propoxylated isosorbide exhibited notable mechanical performance
(50 MPa tensile strength and 1150% elongation with hyperelasticity under cyclic
load). The shape-memory effect was also revealed in different forms (film, thread, and
3D scaffold) with 40%â80% recovery in tension or compression mode after plastic
deformation. The ultra-cell-adhesive property was proven in various cell types which
were reasoned to involve the heat shock protein-mediated integrin (α5 and αV) activation,
as analyzed by RNA sequencing and inhibition tests. After the tissue regenerative
potential (muscle and bone) was confirmed by the myogenic and osteogenic responses in vitro, biodegradability, compatible in vivo tissue response, and healing
capacity were investigated with in vivo shape-memorable behavior. The currently
exploited PCL-PU, with its multifunctional (hyperelastic, shape-memorable, ultra-celladhesive,
and degradable) nature and biocompatibility, is considered a potential tissue-
regenerative biomaterial, especially for minimally invasive surgery that requires
small incisions to approach large defects with excellent regeneration capacity
Communicating product user reviews and ratings in interfaces for e-commerce: a multimodal approach
This paper describes a comparative empirical evaluation study that uses multimodal presentations to communicate review messages in an e-commerce platform. Previous studies demonstrate the effective use of multimodality in different problem domains (e.g. e-learning). In this paper, multimodality and expressive avatars are used to communicate information related to product reviews messages. The data of the reviews was opportunistically collected from Facebook and Twitter. Two independent groups of users were used to evaluate two different presentations of reviews and ratings using as a basis an experimental e- commerce platform. The control group used a text-based with emojis presentation and the experimental group used a multimodal approach based on expressive avatars. Three parameters of usability were measured. These were efficiency, effectiveness, user satisfaction, and user preference. The result showed that the two approaches performed similarly. These findings provide a basis for further experiments in which text, emojis and expressive avatars can be combine to communicate a larger volume of reviews and ratings
Transfer function solving, simulating and testing of thermal dynamics characteristics of a ballscrew
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