Intramanual and intermanual transfer of the curvature aftereffect

The existence and transfer of a haptic curvature aftereffect was investigated to obtain a greater insight into neural representation of shape. The haptic curvature aftereffect is the phenomenon whereby a flat surface is judged concave if the preceding touched stimulus was convex and vice versa. Single fingers were used to touch the subsequently presented stimuli. A substantial aftereffect was found when the adaptation surface and the test surface were touched by the same finger. Furthermore, a partial, but significant transfer of the aftereffect was demonstrated between fingers of the same hand and between fingers of both the hands. These results provide evidence that curvature information is not only represented at a level that is directly connected to the mechanoreceptors of individual fingers but is also represented at a stage in the somatosensory cortex shared by the fingers of both the hands

Michael Porter’s Competitiveness Framework—Recent Learnings and New Research Priorities

The conceptual framework of competitiveness and clusters introduced by Michael Porter in his Competitive Advantage of Nations (Free, New York, 1990 ) remains exceptionally influential, especially among practitioners. The article discusses recent learnings about Porter's conceptual framework from practical applications and research directly driven by his work. It also outlines developments in the creation and analysis of empirical datasets and the analysis of policy processes, two main areas of current research in this field that are likely to increase in importance. The aim is to provide a coherent and current representation of key elements of the framework, while also discussing a few misperceptions about the concept present among practitioners or researchers. Copyright Springer Science + Business Media, LLC 2006competitiveness, clusters, business environment, analysis, F23, L52, O13, O57, R12,

Effects of exercise on fitness and cognition in progressive MS: a randomized, controlled pilot trial

Background: Exercise may have beneficial effects on both well-being and walking ability in multiple sclerosis (MS). Exercise is shown to be neuroprotective in rodents and may also enhance cognitive function in humans. It may, therefore, be particularly useful for MS patients with pronounced neurodegeneration. Objective: To investigate the potential of standardized exercise as a therapeutic intervention for progressive MS, in a randomized-controlled pilot trial. Methods: Patients with progressive MS and moderate disability (Expanded Disability Status Scale (EDSS) of 4–6) were randomized to one of three exercise interventions (arm ergometry, rowing, bicycle ergometry) for 8–10 weeks or a waitlist control group. We analyzed the drop-out rate as a measure of feasibility. The primary endpoint of the study was aerobic fitness. Secondary endpoints were walking ability, cognitive function as measured by a neuropsychological test battery, depression and fatigue. Results: A total of 42 patients completed the trial (10.6% drop-out rate). Significant improvements were seen in aerobic fitness. In addition, exercise improved walking ability, depressive symptoms, fatigue and several domains of cognitive function. Conclusion: This study indicated that aerobic training is feasible and could be beneficial for patients with progressive MS. Larger exercise studies are needed to confirm the effect on cognition