Recommendations for Early Phases of Engaging Communities in Climate Change Adaptation

Communities across the globe have begun planning for and adapting to climate change. Cooperative Extension Service professionals are in a unique position to use the resources available to them to facilitate climate change adaptation in their communities. Adaptation planning is a local activity that must be context specific. However, general recommendations can be made to help facilitate the planning process. In this study, we conducted a systematic review of research about climate change adaptation in communities to explore ideas that contribute to successful adaptation-planning communication. We identified and reviewed 50 peer-reviewed articles that described various outreach efforts to engage communities in planning for adaptation across a range of contexts and settings. Five themes emerged addressing how to facilitate early stages of the climate change adaptation process: establishing positive initial engagement, incorporating participatory methods, using tools to facilitate understanding, addressing trust and uncertainty, and maximizing limited time. Based on the review and emergent themes, we offer practical recommendations for educators and Cooperative Extension Service professionals as they engage communities in climate change adaptation

Local and distributed PiB accumulation associated with development of preclinical Alzheimer\u27s disease

Amyloid-beta plaques are a hallmark of Alzheimer\u27s disease (AD) that can be assessed by amyloid imaging (e.g., Pittsburgh B compound [PiB]) and summarized as a scalar value. Summary values may have clinical utility but are an average over many regions of interest, potentially obscuring important topography. This study investigates the longitudinal evolution of amyloid topographies in cognitively normal older adults who had normal (N = 131) or abnormal (N = 26) PiB scans at baseline. At 3 years follow-up, 16 participants with a previously normal PiB scan had conversion to PiB scans consistent with preclinical AD. We investigated the multivariate relationship (canonical correlation) between baseline and follow-up PiB topographies. Furthermore, we used penalized regression to investigate the added information derived from PiB topography compared to summary measures. PiB accumulation can be local, that is, a topography predicting the same topography in the future, and/or distributed, that is, one topography predicting another. Both local and distributed PiB accumulation was associated with conversion of PiB status. Additionally, elements of the multivariate topography, and not the commonly used summary scalar, correlated with future PiB changes. Consideration of the entire multivariate PiB topography provides additional information regarding the development of amyloid-beta pathology in very early preclinical AD

Mental Models of Soil Management for Food Security in Peri-Urban India

Agricultural development during the Green Revolution brought India food sovereignty but food insecurity persists. Increased crop production was promoted without considering the more holistic impact on food security. Scientists, extension agents, and farmers have different perspectives on how soil health relates to food security. Understanding stakeholders’ perspectives is essential to improving extension communication and mitigating consequences. This study uses qualitative interviews to construct mental models of soil health for food security. The study site is a peri-urban watershed, which is currently participating in the Integrated Farmer Participatory Watershed Management Model (IFPWM). Our study details and defines stakeholders’ mental models of soil health, soil nutrient management, soil sodicity, and food security. A triad belief held by farmers shows the strongly perceived causal relationship between soil health, plant health, and human health. Healthy soil produces healthy food and humans that eat such food will be healthy. Scientists only perceive one condition to achieving food security in the community—food quantity. However, all other stakeholders perceived another risk to food security—food quality. Eating poor quality food is perceived as linked to human health problems in the community. This research suggests the importance of including a fifth dimension of food security, cultural acceptability, within agricultural technology development and dissemination

Stable isotopic composition of upper oceanic crust formed at a fast spreading ridge, ODP Site 801

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94808/1/ggge303.pd

O2‐08‐05: Neuronal Injury and Degeneration Evaluated with Imaging and CSF Biomarkers in Autosomal Dominant Alzheimer’s Disease: Results from the Dian Study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152556/1/alzjjalz201606440.pd

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Insulin resistance (IR), an impaired cellular, tissue and whole body response to insulin, is a major pathophysiological defect of type 2 diabetes mellitus. Although IR is closely associated with obesity, the identity of the molecular defect(s) underlying obesity-induced IR in skeletal muscle remains controversial; reduced post-receptor signalling of the insulin receptor substrate 1 (IRS1) adaptor protein and downstream effectors such as protein kinase B (PKB) have previously been implicated. We examined expression and/or activation of a number of components of the insulin-signalling cascade in skeletal muscle of 22 healthy young men (with body mass index (BMI) range, 20–37 kg/m2). Whole body insulin sensitivity (M value) and body composition was determined by the hyperinsulinaemic (40 mU. min−1.m−2.), euglycaemic clamp and by dual energy X-ray absorptiometry (DEXA) respectively. Skeletal muscle (vastus lateralis) biopsies were taken before and after one hour of hyperinsulinaemia and the muscle insulin signalling proteins examined by western blot and immunoprecipitation assay. There was a strong inverse relationship between M-value and BMI. The most striking abnormality was significantly reduced insulin-induced activation of p42/44 MAP kinase, measured by specific assay, in the volunteers with poor insulin sensitivity. However, there was no relationship between individuals' BMI or M-value and protein expression/phosphorylation of IRS1, PKB, or p42/44 MAP kinase protein, under basal or hyperinsulinaemic conditions. In the few individuals with poor insulin sensitivity but preserved p42/44 MAP kinase activation, other signalling defects were evident. These findings implicate defective p42/44 MAP kinase signalling as a potential contributor to obesity-related IR in a non-diabetic population, although clearly multiple signalling defects underlie obesity associated IR

IntAct—open source resource for molecular interaction data

IntAct is an open source database and software suite for modeling, storing and analyzing molecular interaction data. The data available in the database originates entirely from published literature and is manually annotated by expert biologists to a high level of detail, including experimental methods, conditions and interacting domains. The database features over 126 000 binary interactions extracted from over 2100 scientific publications and makes extensive use of controlled vocabularies. The web site provides tools allowing users to search, visualize and download data from the repository. IntAct supports and encourages local installations as well as direct data submission and curation collaborations. IntAct source code and data are freely available from