Prevention and treatment of peri-implant diseases—The EFP S3 level clinical practice guideline

Background: The recently published Clinical Practice Guidelines (CPGs) for the treatment of stages I–IV periodontitis provided evidence-based recommendations for treating periodontitis patients, defined according to the 2018 classification. Peri-implant diseases were also re-defined in the 2018 classification. It is well established that both peri-implant mucositis and peri-implantitis are highly prevalent. In addition, peri-implantitis is particularly challenging to manage and is accompanied by significant morbidity. Aim: To develop an S3 level CPG for the prevention and treatment of peri-implant diseases, focusing on the implementation of interdisciplinary approaches required to prevent the development of peri-implant diseases or their recurrence, and to treat/rehabilitate patients with dental implants following the development of peri-implant diseases. Materials and Methods: This S3 level CPG was developed by the European Federation of Periodontology, following methodological guidance from the Association of Scientific Medical Societies in Germany and the Grading of Recommendations Assessment, Development and Evaluation process. A rigorous and transparent process included synthesis of relevant research in 13 specifically commissioned systematic reviews, evaluation of the quality and strength of evidence, formulation of specific recommendations, and a structured consensus process involving leading experts and a broad base of stakeholders. Results: The S3 level CPG for the prevention and treatment of peri-implant diseases culminated in the recommendation for implementation of various different interventions before, during and after implant placement/loading. Prevention of peri-implant diseases should commence when dental implants are planned, surgically placed and prosthetically loaded. Once the implants are loaded and in function, a supportive peri-implant care programme should be structured, including periodical assessment of peri-implant tissue health. If peri-implant mucositis or peri-implantitis are detected, appropriate treatments for their management must be rendered. Conclusion: The present S3 level CPG informs clinical practice, health systems, policymakers and, indirectly, the public on the available and most effective modalities to maintain healthy peri-implant tissues, and to manage peri-implant diseases, according to the available evidence at the time of publication

Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline

Background: The recently introduced 2017 World Workshop on the classification of periodontitis, incorporating stages and grades of disease, aims to link disease classification with approaches to prevention and treatment, as it describes not only disease severity and extent but also the degree of complexity and an individual's risk. There is, therefore, a need for evidence-based clinical guidelines providing recommendations to treat periodontitis. Aim: The objective of the current project was to develop a S3 Level Clinical Practice Guideline (CPG) for the treatment of Stage I–III periodontitis. Material and Methods: This S3 CPG was developed under the auspices of the European Federation of Periodontology (EFP), following the methodological guidance of the Association of Scientific Medical Societies in Germany and the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The rigorous and transparent process included synthesis of relevant research in 15 specifically commissioned systematic reviews, evaluation of the quality and strength of evidence, the formulation of specific recommendations and consensus, on those recommendations, by leading experts and a broad base of stakeholders. Results: The S3 CPG approaches the treatment of periodontitis (stages I, II and III) using a pre-established stepwise approach to therapy that, depending on the disease stage, should be incremental, each including different interventions. Consensus was achieved on recommendations covering different interventions, aimed at (a) behavioural changes, supragingival biofilm, gingival inflammation and risk factor control; (b) supra- and sub-gingival instrumentation, with and without adjunctive therapies; (c) different types of periodontal surgical interventions; and (d) the necessary supportive periodontal care to extend benefits over time. Conclusion: This S3 guideline informs clinical practice, health systems, policymakers and, indirectly, the public on the available and most effective modalities to treat periodontitis and to maintain a healthy dentition for a lifetime, according to the available evidence at the time of publication

Fachkommunikation zur effektiveren Entwicklung der Umwelttechnik in Nordthueringen zur nachhaltigen Foerderung der Bergbauregion

The southern Harz mountain range was a potassium mining region for the past 100 years. When this industry died out, a landscape of typical abandoned mining sites was left behind. Since the nineties, attempts are made to use this landscape as a resource. The project ws to develop attractive communication media for experts of Nordhausen Technical University and their partners. Combined efforts are envisaged to develop abandoned potassium mines and to market knowledge on traditional potassium mining on an international scale. Goals are: Safeguarding the business of local enterprises; extending the range of business; integration of further processing and utilisation steps; supraregional and international marketing of special knowledge.Der Suedharzraum war waehrend der letzten einhundert Jahre gepraegt von der Rohstoffgewinnung der Kalisalze. Die Dominanz des primaeren und sekundaeren Sektors in dieser Region fuehrte in der Vergangenheit zu einer einseitig ausgerichteten Entwicklung im Raum, welche zu Beginn der neunziger Jahre nach dem endgueltigen Aus der Rohstoffgewinnung und -verarbeitung durch die grosse Zahl branchentypischer Industriebrachflaechen deutlich belegt wurde. Unter Ausnutzung der vorhandenen Infrastruktur wurde Anfang der neunziger Jahre damit begonnen, die Bergbaufolgelandschaft als 'Ressource' zu verstehen, zu nutzen und umzugestalten. Im Projekt sollten informative 'attraktive' Kommunikationsmittel fuer Fachleute von der Fachhochschule Nordhausen gemeinsam mit Wissenstraegern erarbeitet werden, die das Gesamtvorhaben stuetzen. Zielstellung war es, durch wissenschaftlich fundierte Fachpublikationen und Events die fachbezogene Kommunikation voranzutreiben. Die Zielstellung, durch Buendelung der Kraefte, den Ausbau an den Kalialtstandorten zu forcieren und traditionelles Kaliwissen international zu vermarkten, wurde durch zahlreiche Aktivitaeten unterstuetzt. Durch Synergieeffekte werden daraus positive Effektive fuer die Entwicklung der Einzelunternehmen abgeleitet, insbesondere in Hinblick auf - die Sicherung der Unternehmensbasis, - die Ausweitung der Geschaeftsfelder, - durch Einbeziehung zusaetzlicher Verwertungsschritte, - die ueberregionale und internationale Vermarktung der Spezialkenntnisse. (orig.)With CD-ROM and 7 brochuresSIGLEAvailable from TIB Hannover: F02B1060 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDeutsche Bundesstiftung Umwelt, Osnabrueck (Germany)DEGerman

Genetic markers among meiteis and brahmins of Manipur, India

Genetic polymorphism of 16 red-cell antigens, enzymes, serum proteins and Hb variants was investigated in 214 male and female individuals belonging to the Meiteis and a Brahmin caste group living in Imphal (Manipur, Northeast India). Ethno-historical records suggest that the Meiteis are of Mongoloid origin, while the original Brahmin settlers represent the easternmost part of the so-called Caucasoids. The markers studied are: A1A2BO, MNSs, Rh-system, Duffy, Diego; Gm, Km, Gc, Hp, Tf, Cp; Hb; aP, AK, EsD and LDH. The comparison between the two groups on the basis of the markers studied showed that the Meiteis and Brahmins are very close to each other with respect to most of the loci except Gm, EsD and Hb, where significant statistical differences were found