An HIV-1 infected patient with Neurofibromatosis type 1: A case report

Background: Although HIV-1 infection predisposes an individual to well defined neoplasia, neurofibromas have not been reported as some of the typical ones. The association between HIV-1 infection and neurofibromatosis type 1, a genetic disorder, should be of interest because HIV infection could alter the natural biology of its cutaneous manifestations. However, reports on simultaneous occurrence of these conditions in an individual are rare.Method: The case records of a 30 year old HIV 1 positive female receiving care at the Jos University teaching hospital centre and a review of the relevant literature was utilised.Result: We present a 30 year old HIV positive woman with florid cutaneous lesions of familial neurofibromatosis type  1 who had adequate response to antiretroviral therapyConclusion: HIV infection and treatment did not seem toaffect the clinico- pathological features of the neurofibromatosis lesions.Key Words: Neurofibromatosis type 1, HIV Infection, cutaneous lesions, HAAR

Parkinsonism caused by adverse drug reactions: a case series

<p>Abstract</p> <p>Introduction</p> <p>Parkinsonism puts a high direct cost burden on both patient and caregiver. Several reports of drug-induced parkinsonism have been published, but to the best of our knowledge, there has not been any report of quinine or halothane inducing parkinsonism.</p> <p>Case presentation</p> <p>We describe two cases of parkinsonism possibly caused by adverse drug reaction to quinine in a 29-year-old black Nigerian woman and to halothane in a 36-year-old black Hausa (Nigerian) man who received it as general anaesthesia for appendicectomy in our teaching hospital.</p> <p>Conclusion</p> <p>These are two unusual cases of parkinsonism caused by adverse drug reactions to high-dose quinine and to halothane as general anaesthesia. We consider that these two cases are important in bringing this potential side-effect to the attention of both pharmacologists and primary care physicians as these are two of the most commonly used medications in our clinics. We conclude that parkinsonism should be included among the adverse drug reactions to high-dose quinine and halothane general anaesthetic.</p