Boolean Lifting Properties for Bounded Distributive Lattices

In this paper, we introduce the lifting properties for the Boolean elements of bounded distributive lattices with respect to the congruences, filters and ideals, we establish how they relate to each other and to significant algebraic properties, and we determine important classes of bounded distributive lattices which satisfy these lifting properties

A TQFT associated to the LMO invariant of three-dimensional manifolds

We construct a Topological Quantum Field Theory (in the sense of Atiyah) associated to the universal finite-type invariant of 3-dimensional manifolds, as a functor from the category of 3-dimensional manifolds with parametrized boundary, satisfying some additional conditions, to an algebraic-combinatorial category. It is built together with its truncations with respect to a natural grading, and we prove that these TQFTs are non-degenerate and anomaly-free. The TQFT(s) induce(s) a (series of) representation(s) of a subgroup ${\cal L}_g$ of the Mapping Class Group that contains the Torelli group. The N=1 truncation produces a TQFT for the Casson-Walker-Lescop invariant.Comment: 28 pages, 13 postscript figures. Version 2 (Section 1 has been considerably shorten, and section 3 has been slightly shorten, since they will constitute a separate paper. Section 4, which contained only announce of results, has been suprimated; it will appear in detail elsewhere. Consequently some statements have been re-numbered. No mathematical changes have been made.

Design, synthesis and molecular modelling of new thiazolidines 2,3-disubstituted with antitumoral activity

cited By 5International audienceNew thiazolidine 2,3 disubstituted derivatives of 1'-acetamidyl-5'-nitroindazole with antitumoral activity against the Walker Carcinosarcoma and Jensen Sarcoma were designed and synthesized. The structural features of new compounds have been established by chemical elemental and spectral ( 1HNMR and IR) analyses. The optimized molecular geometry, the length of the covalent bonds, the atomic charges and some electro-optical parameters influencing the bioactivity of the new compounds were established by using HyperChem 5.0 programs. The determined values of the 1,3-thiazolidines toxicity are in the limits of the laboratory screening. The new compounds prove inhibition activity when they were tested on experimental tumors, the most active being 4-oxo-1,3-thiazolidine (VI) with ortho-hydroxy-phenyl

Enhanced antipyretic activity of new 2, 5-substituted 1, 3, 4-oxadiazoles encapsulated in alginate/gelatin particulated systems

cited By 4International audienceNew 1,3,4-oxadiazoles with pharmacological potential, derived from 5-nitroindazole, have been synthesized. Their chemical structure has been established by elemental and spectral analyses (FT-IR and 1H-NMR). The oxadiazoles presented low toxicity, one compound, either in a free form or loaded in polymeric microcapsules, also showing a remarkable antipyretic activity, similar to that of acetylsalicylic acid

Synthesis and antimicrobial activity of new amidic derivatives of 5-nitroindazol-1-yl acetic acid encapsulated into alginate/pectin particles

International audienceNew amidic compounds with biologic activity, derived from 5-nitroindazol-1-yl-acetic acid have been synthesised and their chemical structure was confirmed by elemental and spectral analysis (FT-IR, 1H-NMR, 13C-NMR and mass spectrometry). The incorporation of some of the amides into sodium alginate and pectin based microcapsules, prepared by polymer ionotropic gelation in OAV emulsion determined the augmentation of their antibacterial potential against bacterial strains

Polyelectrolyte complex based nanocapsules carrying novel 5-nitroindazole thiazolidines with potential use in treating oral infections

International audienceThe aim of this research was the synthesis of novel 2,3-disubstituted 1,3 thiazolidines, derived from 5- nitroindazole with antimicrobial activity and their encapsulation into polymer nanocapsules. Starting from previously synthesised hydrazones, there have been obtained novel thiazolidines by reaction with thioglycolic acid. The envisaged chemical structures were confirmed by spectral and elemental analysis. Two of the obtained thiazolidines were encapsulated into cationic Eudragit E100 nanocapsules, obtained by nanoprecipitation. In order to enhance drug release characteristics and particle stability, Eudragit E100 nanocapsules were covered with anionic polysaccharide (sodium alginate), thus forming a complex polyelectrolyte based membrane. The obtained nanocapsules presented a slower and more controlled drug release. The synthesized active principles, in free state and encapsulated into polymer nanocapsules, were tested for their acute toxicity and their influence on the development of model bacterial strains (Staphylococcus mutans, Actinobacillus actinomycetemcomitans, Bacillus subtilis, Bacillus cereus, Salmonella enteritidis, Escherichia coli and Staphylococcus aureus)

OPTIMIZATION REACTION FOR OBTAINING SOME N-[P-(R)-BENZOYL]-L- GLUTAMINE DERIVATIVES WITH PHARMACEUTICAL ACTION

The conditions in which the obtaining reactions of some N-[p-(R)-Benzoyl]-L-Glutamine derivatives are made with the highest yield were established in this paper. Due to their antitumoral effects, the action of glutamine derivatives on the digestive enzymes has been evaluated