Auditory Filters Measured at Neighboring Center Frequencies

Auditory filters were derived in 20 normal-hearing human listeners at center frequencies (CFs) of 913, 1095, 3651, and 4382 Hz using the roex (p,r) method. Comparisons were made between slopes of the filters\u27 skirts at the neighboring CFs with filter output levels of 45 and 70 dB. The same comparisons were made with regard to filter equivalent rectangular bandwidth (ERB). In the 1000-Hz region, the low-frequency slopes (Pl) of filters centered at 913 and 1095 Hz were significantly correlated at both stimulus levels, while the high-frequency slopes (Pu) were similar only at the high test level. In the 4000-Hz region, for sinusoids of 3651 and 4382 Hz, the level effect was clearer as both Pu and Pl values diverged at the low level but were related at high levels. The ERBs centered at the same CFs displayed a similar level dependence. At the stimulus level most likely to be affected by an active feedback mechanism, auditory filters centered at nearly the same frequency displayed quite distinct frequency selectivity, and this trend was stronger in the 4000-Hz region than the 1000-Hz region. The findings suggest that a saturating, active cochlear mechanism may not be distributed evenly, or contribute to peripheral tuning with equal effectiveness throughout the length of the partition

Modeling of bone conduction of sound in the human head using hp-finite elements: Code design and verification

We focus on the development of a reliable numerical model for investigating the bone-conduction of sound in the human head. The main challenge of the problem is the lack of fundamental knowledge regarding the transmission of acoustic energy through non-airborne pathways to the cochlea. A fully coupled model based on the acoustic/elastic interaction problem with a detailed resolution of the cochlea region and its interface with the skull and the air pathways, should provide an insight into this fundamental, long standing research problem. To this aim we have developed a 3D hp-finite element code that supports elements of all shapes (tetrahedra, prisms and pyramids) to better capture the geometrical features of the head. We have tested the code on a multilayered sphere and employed it to solve an idealized model of head. In the future we hope to attack a model with a more realistic geometry

Avian response to microclimate in canopy gaps in a bottomland hardwood forest.

Abstract - Microclimate may infl uence use of early successional habitat by birds. We assessed the relationships between avian habitat use and microclimate (temperature, light intensity, and relative humidity) in experimentally created canopy gaps in a bottomland hardwood forest on the Savannah River Site, SC. Gaps were 2- to 3-year-old group-selection timber harvest openings of three sizes (0.13, 0.26, 0.50 ha). Our study was conducted from spring through fall, encompassing four bird-use periods (spring migration, breeding, post-breeding, and fall migration), in 2002 and 2003. We used mist netting and simultaneously recorded microclimate variables to determine the influence of microclimate on bird habitat use. Microclimate was strongly affected by net location within canopy gaps in both years. Temperature generally was higher on the west side of gaps, light intensity was greater in gap centers, and relative humidity was higher on the east side of gaps. However, we found few relationships between bird captures and the microclimate variables. Bird captures were inversely correlated with temperature during the breeding and postbreeding periods in 2002 and positively correlated with temperature during spring 2003. Captures were high where humidity was high during post-breeding 2002, and captures were low where humidity was high during spring 2003. We conclude that variations in the local microclimate had minor infl uence on avian habitat use within gaps. Instead, habitat selection in relatively mild regions like the southeastern US is based primarily on vegetation structure, while other factors, including microclimate, are less important

The Future of Healthcare Delivery: IPE/IPP Audiology and Nursing Student/Faculty Collaboration to Deliver Hearing Aids to Vulnerable Adults via Telehealth

A multi-departmental, two-city initiative to provide hearing aid service via a telepractice approach was developed whereby nursing and auditory students with supervisory faculty used AV conferencing for training and interaction with referred patients. Located in two cities, 21 nursing and 15 doctoral level audiology students met virtually, and students received teleaudiology education and practicum with interprofessional education and practice components. Nursing students in one city and a supervising faculty in another city could interact with providers and patients in both cities to provide hearing care. The teleaudiology project delivered hearing health care services, including fitting of digital mini hearing aids, to 181 patients over 29 months of the project. During that time period, 205 total patients were referred to the teleaudiology clinic. Over 90% of these patients, as assessed by either patient teleaudiology clinic visits or telephone follow-up, successfully wore their hearing aids. Students administered selected published surveys related to patient outcomes both pre and post fitting. Patients reported significant hearing handicap reduction and were very satisfied with the teleaudiology mode of digital hearing aid and hearing health care service delivery. The experience provided interprofessional pre-service exposure to cutting edge technology and an innovative delivery system for future members of the healthcare workforce

Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for Patients in the 6th and 7th Decades of Life with AML or MDS Using Myeloablative, Reduced Toxicity IV Busulfan/Fludarabine (BuFlu) Conditioning Regimen

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Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor

Author Posting. © The Author(s), 2014. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Aquatic Toxicology 159 (2015): 198-207, doi:10.1016/j.aquatox.2014.12.010.Killifish survive and reproduce in the New Bedford Harbor (NBH) in Massachusetts (MA), USA, a site severely contaminated with polychlorinated biphenyls (PCBs) for decades. Levels of 22 different PCB congeners were analyzed in liver from killifish collected in 2008. Concentrations of dioxin-like PCBs in liver of NBH killifish were ~400 times higher, and the levels of non-dioxin-like PCBs ~3000 times higher than in killifish from a reference site, Scorton Creek (SC), MA. The NBH killifish are known to be resistant to the toxicity of dioxin-like compounds and to have a reduced aryl hydrocarbon receptor (AhR) signaling response. Little is known about the responses of these fish to non-dioxin-like PCBs, which are at extraordinarily high levels in NBH fish. In mammals, some non-dioxin-like PCB congeners act through nuclear receptor 1I2, the pregnane-X-receptor (PXR). To explore this pathway in killifish, a PXR cDNA was sequenced and its molecular phylogenetic relationship to other vertebrate PXRs was determined. Killifish were also collected in 2009 from NBH and SC, and after four months in the laboratory they were injected with a single dose of either the dioxin-like PCB 126 (an AhR agonist) or the non-dioxin-like PCB 153 (a mammalian PXR agonist). Gills and liver were sampled three days after injection and transcript levels of PXR, cytochrome P450 3A (CYP3A), P-glycoprotein (Pgp), AhR2 and cytochrome P450 1A (CYP1A) were measured by quantitative PCR. As expected, there was little effect of PCB exposure on AhR2 or CYP1A in liver and gills of NBH fish. In NBH fish, but not in SC fish, there was increased expression of hepatic PXR, CYP3A and Pgp genes upon exposure to either of the two PCB congeners. However, basal PXR and Pgp mRNA levels in liver of NBH fish were significantly lower than in SC fish. A different pattern was seen in gills, where there were no differences in basal expression of these genes between the two populations. In SC fish, but not in NBH fish, there was increased expression of branchial PXR and CYP3A upon exposure to PCB126 and of CYP3A upon exposure to PCB153. The results suggest a difference between the two populations in non-AhR transcription factor signaling in liver and gills, and that this could involve killifish PXR. It also implies possible cross-regulatory interactions between that factor (presumably PXR) and AhR2 in liver of these fish.This study was supported by grants from FORMAS (216-2007-468) and University of Gothenburg to MCC, and by the Superfund Research Program at Boston University, NIH grant P42ES007381 to JJS, MEH, and SIK. Data interpretation was aided by reference to a preliminary draft of the Fundulus heteroclitus genome sequence, which was supported by funding from the National Science Foundation (collaborative research grants DEB-1120512, DEB-1265282, DEB-1120013, DEB-1120263, DEB-1120333, DEB-1120398). This study was also supported by NOAA Grant No. NA16RG2273 (WHOI Sea Grant Project No. R/P-70 to SIK and MEH) and by funding from Adlerbertska Forskningsstiftelsen, Helge Ax:son Johnsons Stiftelse and Wilhelm och Martina Lundgrens Vetenskapsfond to BW and JG