THE EFFECT OF DEOXYNIVALENOL ON

Abstract: The biochemical effect of deoxynivalenol on HepG2 hepatocarcinom cells was examined at a concentration of 2.5 μM and 24h of exposure. The antioxidant enzyme specific activities increased. Our results revealed that HepG2 cells exposed to this mycotoxin developed specific adaptative responses neutralizing oxidative stress. Key words: deoxyivalenol, HepG2, antioxidant enzyme Introduction and literature review Deoxynivalenol (DON, vomitoxin) is a type B trichothecene, an epoxysesquiter-penoid. This mycotoxin occurs predominantly in grains such as wheat, barley, oats, rye, and maize. The occurrence of deoxynivalenol is associated with Fusarium graminearum and F. culmorum, both of which ar