37 research outputs found
The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
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Effect of fluorination on the pharmacological profile of 11β isomers of fulvestrant in breast carcinoma cells
No full textWe describe the synthesis of an 11beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ERalpha). This result suggests that ERalpha down-regulation is not a sine qua non condition for the antitumor activity of steroidal antiestrogens.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
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Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives
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Synthesis and antibacterial activity of 2, 3-dehydro-3-O-(3-aryl-E-prop-2-enyl)-10, 11-anhydroclarithromycin derivatives
No full textSynthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A
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