Quantification of atherosclerotic lesions.

<p>(A) Sections of aortic sinus (at 500 µm from the cusps) stained with oil red O. The arrows indicate lipid deposit. (B) Atherosclerotic lesion severity is expressed as percent changes of lesion area in total cross-sectional area. Data represent means ± SEM (n = 20/group). ^a,b,c Mean values with unlike letters were significantly different (p<0.05).</p

Profiles of PUFAs’s oxygenated metabolites.

<p>(A) Plasma concentrations of oxylipins originating from AA (20∶4 n-6), EPA (20∶5 n-3), and DHA (22∶6 n-3). (B) Liver contents of peroxidation metabolites originating from n-6 PUFAs (4-HNE-P), n-3 PUFAs (4-HHE-P) and DHA (F₄-NeuroPs). Data represent means ± SEM (n = 10/group). ^a,b,c Mean values with unlike letters were significantly different (p<0.05).</p

Plasma (A) and liver (B) fatty acid profiles (% total FA).

<p>The 4 families of fatty acid (i.e. saturated fatty acids (SFA), monounsaturated fatty acids (MUFA), n-6 PUFA and n-3 PUFA) are represented with different grey shades from black to light grey. Data represent means ± SEM (n = 10/group).</p

Correlations between the doses of DHA and the cardiovascular parameters (i.e. plasma TG and TC, liver TG and TC, sBP, and plaque area).

<p>LDLR^−/− mice were given by daily oral gavages (20 weeks) either oleic acid rich sunflower oil (Control group) or a mixture of oleic acid rich sunflower oil and DHA rich tuna oil providing 0.1%, 1% or 2% of energy as DHA (DHA1, DHA2, and DHA3 groups respectively).</p

A Spearman’s correlation heatmap.

<p>Variables rank from the most positive to most negative correlation with arteriosclerotic plaque area. The displayed variables are the 30 most significantly correlated with arteriosclerotic plaque area at p<0.001 with orange indicating positive and blue indicating negative correlations.</p