A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

<p>Abstract</p> <p>Background</p> <p>Marbling score (MS) is the major quantitative trait that affects carcass quality in beef cattle. In this study, we examined the association between genetic polymorphisms of the micromolar calcium-activated neutral protease gene (micro-calpain, <it>CAPN1</it>) and carcass traits in Korean cattle (also known as Hanwoo).</p> <p>Results</p> <p>By direct DNA sequencing in 24 unrelated Korean cattle, we identified 39 sequence variants within exons and their flanking regions in <it>CAPN1</it>. Among them, 12 common polymorphic sites were selected for genotyping in the beef cattle (<it>n </it>= 421). Statistical analysis revealed that a polymorphism in the 3'UTR (<it>c.2151*479C>T</it>) showed significant association with MS (<it>P</it>^{<it>cor</it>.}= 0.02).</p> <p>Conclusion</p> <p>Our findings suggest that polymorphisms in <it>CAPN1 </it>might be one of the important genetic factors involved in carcass quality in beef cattle, although it could be false positive association.</p

Normative Values and Correlates of Mean Common Carotid Intima-Media Thickness in the Korean Rural Middle-aged Population: The Atherosclerosis RIsk of Rural Areas iN Korea General Population (ARIRANG) Study

Carotid intima-media thickness (CIMT) is considered as a surrogate marker for cardiovascular disease (CVD). We determined the normative value of CIMT and correlates of CVD risk factors and Framingham risk score (FRS) in Korean rural middle-aged population. We measured CIMT with a B-mode ultrasonography in 1,759 subjects, aged 40 to 70 yr, in a population-based cohort in Korea. A healthy reference sample (n = 433) without CVD, normal weight and normal metabolic parameters was selected to establish normative CIMT values. Correlates between CIMT and conventional CVD risk factors were assessed in the entire population. Mean values of CIMT (in mm) for healthy reference sample aged 40-49, 50-59, and 60-70 yr were 0.55, 0.59, and 0.66 for men and 0.48, 0.55, and 0.63 for women, respectively. In multivariate regression analysis, CIMT was correlated with older age, higher BMI, male gender, higher LDL-cholesterol level and history of diabetes mellitus. The mean CIMT was also correlated with FRS in both gender (r2 = 0.043, P < 0.01 for men; r2 = 0.142, P < 0.01 for women). We identified normative value of CIMT for the healthy Korean rural middle-aged population. The CIMT is associated with age, obesity, gender, LDL-cholesterol, diabetes mellitus and FRS

Pase: Locating online copy of scientific documents effectively

Abstract. The need for fast and vast dissemination of research results has led a new trend such that more number of authors post their documents to personal or group Web spaces so that others can easily access and download them. Similarly, more and more researchers use online search for accessing documents of interest in Web, instead of paying a visit to libraries. Currently, to locate and download an online copy of a particular document D, one typically (1) uses Search Engines with the citation information and browses through returned web pages (e.g., author’s homepage) to see if any contains D, or (2) uses searching facilities of an individual Digital Library (e.g., CiteSeer, e-Print) looking for D, and if not found, repeats the search in another Digital Library. However, the scheme (1) involves human browsing to get to the final online copy, while the scheme (2) suffers from incomplete coverage. To remedy these shortcomings, in this paper, we present a system, named as PaSE, which can effectively locate online copies (e.g., PDF or PS) of scientific documents using citation information. We consider a myriad of alternatives in crawling and parsing the Web to arrive at the right document quickly, and present a preliminary experimental study. Using some of the best alternatives that we have identified, we show that PaSE can locate online copy of documents more accurately and conveniently than human users would do at the cost of elongated search time.

System Support for Name Authority Control

Abstract. In maintaining Digital Libraries, having bibliographic data up-to-date is critical, yet often minor irregularities may cause information isolation. Unlike documents for which various kinds of unique ID systems exist (e.g., DOI, ISBN), other bibliographic entities such as author and publication venue do not have unique IDs. Therefore, in current Digital Libraries, tracking such bibliographic entities is not trivial. For instance, suppose a scholar changes her last name from A to B. Then, a user, searching for her publications under the new name B, cannot get old publications that appeared under A although they are by the same person. For such a scenario, since both A and B are the same person, it would be desirable for Digital Libraries to track their identities accordingly. In this paper, we investigate this problem known as name authority control, and present our system-oriented solution. We first identify three core building blocks that underlie the phenomenon, and show taxonomy where different combinations of the building blocks can occur. Then, we consider how systems can support the problem in two common functions of Digital Libraries- Update and Search. Finally, our test-bed called OpenDBLP is presented where the suggested solution is fully implemented as a proof of the concept. 1