3D modelling of angiogenesis and vascular tumour growth

This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute

Dissolution dominating calcification process in polar pteropods close to the point of aragonite undersaturation

Thecosome pteropods are abundant upper-ocean zooplankton that build aragonite shells. Ocean acidification results in the lowering of aragonite saturation levels in the surface layers, and several incubation studies have shown that rates of calcification in these organisms decrease as a result. This study provides a weight-specific net calcification rate function for thecosome pteropods that includes both rates of dissolution and calcification over a range of plausible future aragonite saturation states (Omega_Ar). We measured gross dissolution in the pteropod Limacina helicina antarctica in the Scotia Sea (Southern Ocean) by incubating living specimens across a range of aragonite saturation states for a maximum of 14 days. Specimens started dissolving almost immediately upon exposure to undersaturated conditions (Omega_Ar,0.8), losing 1.4% of shell mass per day. The observed rate of gross dissolution was different from that predicted by rate law kinetics of aragonite dissolution, in being higher at Var levels slightly above 1 and lower at Omega_Ar levels of between 1 and 0.8. This indicates that shell mass is affected by even transitional levels of saturation, but there is, nevertheless, some partial means of protection for shells when in undersaturated conditions. A function for gross dissolution against Var derived from the present observations was compared to a function for gross calcification derived by a different study, and showed that dissolution became the dominating process even at Omega_Ar levels close to 1, with net shell growth ceasing at an Omega_Ar of 1.03. Gross dissolution increasingly dominated net change in shell mass as saturation levels decreased below 1. As well as influencing their viability, such dissolution of pteropod shells in the surface layers will result in slower sinking velocities and decreased carbon and carbonate fluxes to the deep ocean

Comparison of speech intelligibility in quiet and in noise after hearing aid fitting according to a purely prescriptive and a comparative fitting procedure

We compared two different types of hearing-aid fitting procedures in a double-blind randomized clinical study. Hearing aid fittings based on a purely prescriptive procedure (the NAL-RP formula) were compared to a comparative fitting procedure based on optimizing speech intelligibility scores. Main outcome measures were improvement of speech intelligibility scores in quiet and in noise. Data were related to the real-ear insertion responses that were measured after fitting. For analysis purposes subgroups were composed according to degree of hearing loss, characterized by unaided speech intelligibility in quiet, previous experience with hearing aids, unilateral or bilateral fittings and type of hearing aid. We found equal improvement of speech intelligibility in quiet, while fitting according to the prescriptive formula resulted in a somewhat better performance as expressed by the speech-to-noise ratio in comparison to the comparative procedure. Both procedures resulted in comparable real-ear insertion responses

Faecal sludge simulants to aid the development of desludging technologies

This paper presents a review of currently available data from the literature on the undrained shear strength, bulk density, stickiness and debris content of faecal sludge. Those data have been used to develop two different simulants that replicate the full range of shear strengths and densities reported for faecal sludge. Comprehensive specifications are also presented for the debris or solid waste found in latrines to more closely replicate the challenge of pumping faecal sludge. Finally, a design guide has been produced to capture these results and support quantitative performance testing of desludging pumps. The simulants have already been used as part of the Bill & Melinda Gates Foundation's Faecal Sludge Omni-Ingestor project and by Water for People's SaniHub in developing improved desludging pumps. The wider use of these simulants could accelerate the development of pit emptying technologies and help standardize the quantitative evaluation of their performance.The development of the simulants presented here was funded by the Bill & Melinda Gates Foundation under the Faecal Sludge Omni-Ingestor project.This is the author accepted manuscript. The final version is available from IWA Publishing via http://dx.doi.org/10.2166/washdev.2015.01

Profiling people with Parkinson\u27s disease at risk of cognitive decline: Insights from PPMI and ICICLE-PD data

INTRODUCTION A subset of people with Parkinson\u27s disease (PD) develop dementia faster than others. We aimed to profile PD cognitive subtypes at risk of dementia based on their rate of cognitive decline. METHOD Latent class mixed models stratified subtypes in PPMI (N=770) and ICICLE-PD (N=212) datasets based on their decline in the Montreal Cognitive Assessment over at least four years. Baseline demographic and cognitive data at diagnosis were compared between subtypes to determine their clinical profile. RESULTS Four subtypes were identified: two with stable cognition, one with steady decline, and one with rapid decline. Performance on judgement of line orientation, but not category fluency, was associated with steady decline in the PPMI dataset and deficits in category fluency, but not visuospatial function, was associated with steady decline in the ICICLE-PD dataset. DISCUSSION People with PD susceptible to cognitive decline demonstrate unique clinical profiles at diagnosis, although this differed between cohorts

An iterative algorithm for parametrization of shortest length shift registers over finite rings

The construction of shortest feedback shift registers for a finite sequence S_1,...,S_N is considered over the finite ring Z_{p^r}. A novel algorithm is presented that yields a parametrization of all shortest feedback shift registers for the sequence of numbers S_1,...,S_N, thus solving an open problem in the literature. The algorithm iteratively processes each number, starting with S_1, and constructs at each step a particular type of minimal Gr\"obner basis. The construction involves a simple update rule at each step which leads to computational efficiency. It is shown that the algorithm simultaneously computes a similar parametrization for the reciprocal sequence S_N,...,S_1.Comment: Submitte

Feasibility of Photofrin II as a radiosensitizing agent in solid tumors - Preliminary results

Background: Photofrin II has been demonstrated to serve as a specific and selective radiosensitizing agent in in vitro and in vivo tumor models. We aimed to investigate the feasibility of a clinical application of Photofrin II. Material and Methods: 12 patients were included in the study (7 unresectable solid tumors of the pelvic region, 3 malignant gliomas, 1 recurrent oropharyngeal cancer, 1 recurrent adenocarcinoma of the sphenoid sinus). The dose of ionizing irradiation was 30-50.4 Gy; a boost irradiation of 14 Gy was added for the pelvic region. All patients were intravenously injected with 1 mg/kg Photofrin II 24 h prior to the commencement of radiotherapy. Magnetic resonance imaging (MRI) controls and in some cases positron emission tomography (PET) were performed in short intervals. The mean follow-up was 12.9 months. Results: No major adverse events were noted. Minor adverse events consisted of mild diarrhea, nausea and skin reactions. A complete remission was observed in 4/12 patients. A reduction in local tumor volume of > 45% was achieved in 4/12 patients. Stable disease was observed in 4/12 patients. 1 patient showed local disease progression after 5 months. Conclusion: The early follow-up results are encouraging regarding the feasibility of the application of Photofrin II as a radiosensitizing agent

Extensive dissolution of live pteropods in the Southern Ocean

The carbonate chemistry of the surface ocean is rapidly changing with ocean acidification, a result of human activities. In the upper layers of the Southern Ocean, aragonite—a metastable form of calcium carbonate with rapid dissolution kinetics—may become undersaturated by 2050 (ref. 2). Aragonite undersaturation is likely to affect aragonite-shelled organisms, which can dominate surface water communities in polar regions. Here we present analyses of specimens of the pteropod Limacina helicina antarctica that were extracted live from the Southern Ocean early in 2008. We sampled from the top 200m of the water column, where aragonite saturation levels were around 1, as upwelled deep water is mixed with surface water containing anthropogenic CO2. Comparing the shell structure with samples from aragonite-supersaturated regions elsewhere under a scanning electron microscope, we found severe levels of shell dissolution in the undersaturated region alone. According to laboratory incubations of intact samples with a range of aragonite saturation levels, eight days of incubation in aragonite saturation levels of 0.94– 1.12 produces equivalent levels of dissolution. As deep-water upwelling and CO2 absorption by surface waters is likely to increase as a result of human activities2,4, we conclude that upper ocean regions where aragonite-shelled organisms are affected by dissolution are likely to expand

The population genetic structure of the urchin Centrostephanus rodgersii in New Zealand with links to Australia

© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021Publishe

Application of the PISA design model to monopiles embedded in layered soils

The PISA design model is a procedure for the analysis of monopile foundations for offshore wind turbine applications. This design model has been previously calibrated for homogeneous soils; this paper extends the modelling approach to the analysis of monopiles installed at sites where the soil profile is layered. The paper describes a computational study on monopiles embedded in layered soil configurations comprising selected combinations of soft and stiff clay and sand at a range of relative densities. The study comprises (a) analyses of monopile behaviour using detailed three-dimensional (3D) finite-element analysis, and (b) calculations employing the PISA design model. Results from the 3D analyses are used to explore the various influences that soil layering has on the performance of the monopile. The fidelity of the PISA design model is assessed by comparisons with data obtained from equivalent 3D finite-element analyses, demonstrating a good agreement in most cases. This comparative study demonstrates that the PISA design model can be applied successfully to layered soil configurations, except in certain cases involving combinations of very soft clay and very dense sand. </jats:p