Pharmacological methods of therapy in Parkinson’s disease

The review concerns modern pharmacological methods of Parkinson's disease treatment. The basic drugs used in practice are levodopa, dopamine receptor agonists, MAO-B inhibitors, anticholinergics, COMT inhibitors, and amantadine drugs. The article considers main features, assessment methods and targets of the differentiated therapy, presents benefits and drawbacks of each drug, and describes the problem of generics. According to the study, there is a preferences to use long-acting drugs. The choice of a drug for Parkinson's disease treatment depends on such characteristics as the patient's age, the character of Parkinson's disease, the severity of movement disorder, concomitant diseases, the drug price, the patient's individual sensitivity to different drugs. Finally, the article presents recommendations on initial treatment of Parkinson's disease

Diffusive Radiation in One-dimensional Langmuir Turbulence

We calculate spectra of radiation produced by a relativistic particle in the presence of one-dimensional Langmuir turbulence which might be generated by a streaming instability in the plasma, in particular, in the shock front or at the shock-shock interactions. The shape of the radiation spectra is shown to depend sensitively on the angle between the particle velocity and electric field direction. The radiation spectrum in the case of exactly transverse particle motion is degenerate and similar to that of spatially uniform Langmuir oscillations. In case of oblique propagation, the spectrum is more complex, it consists of a number of power-law regions and may contain a distinct high-frequency spectral peak. %at \omega=2\omega\pe \gamma^2. The emission process considered is relevant to various laboratory plasma settings and for astrophysical objects as gamma-ray bursts and collimated jets.Comment: 4 pages, 1 figure, accepted for Phys. Rev.

Diagnostics and therapy of peripheral neuropathy (literature review)

The review is devoted to diagnostics and treatment of neuropathic pain in patients with peripheral nervous system diseases. Main assessment tools are shown including Visual analog Scale (VAS), Neuropathic Pain Scale (NPS), Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), self-report version of the Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), Neuropathic Pain Questionnaire (NPQ), Questionnaire Douleur Neuropathique 4 (DN-4), pain DETECT Questionnaire, Standardized Evaluation of Pain (StEP), identification pain questionnaire (ID-pain), clinical investigation (quantitative sensorial test are included), neurophysiological studies (electroneuromyography, evoked potentials) and MRI. Novel therapy in neuropathic pain disorders is described including both medicamentous and additional therapeutics methods

Ladders for Wilson Loops Beyond Leading Order

We set up a general scheme to resum ladder diagrams for the quark-anti-quark potential in N=4 super-Yang-Mills theory, and do explicit calculations at the next-to-leading order. The results perfectly agree with string theory in AdS(5)xS(5) when continued to strong coupling, in spite of a potential order-of-limits problem.Comment: 18 pages, 5 figure

Relativistic Effects in S-Wave Quarkonium Decay

The decay widths of S-wave quarkonia (\etc,\etb\to \gg{~~and~~} \J,\U\to\ee) are calculated on the basis of a quasipotential approach. The nontrivial dependence on relative quark motion of decay amplitude is taken into consideration via quarkonium wave function. It is shown that relativistic corrections may be large (10-50 %) and comparable with QCD corrections.Comment: 10 pages, no figure

Equilibration processes in the Warm-Hot Intergalactic Medium

The Warm-Hot Intergalactic Medium (WHIM) is thought to contribute about 40-50 % to the baryonic budget at the present evolution stage of the universe. The observed large scale structure is likely to be due to gravitational growth of density fluctuations in the post-inflation era. The evolving cosmic web is governed by non-linear gravitational growth of the initially weak density fluctuations in the dark energy dominated cosmology. Non-linear structure formation, accretion and merging processes, star forming and AGN activity produce gas shocks in the WHIM. Shock waves are converting a fraction of the gravitation power to thermal and non-thermal emission of baryonic/leptonic matter. They provide the most likely way to power the luminous matter in the WHIM. The plasma shocks in the WHIM are expected to be collisionless. Collisionless shocks produce a highly non-equilibrium state with anisotropic temperatures and a large differences in ion and electron temperatures. We discuss the ion and electron heating by the collisionless shocks and then review the plasma processes responsible for the Coulomb equilibration and collisional ionisation equilibrium of oxygen ions in the WHIM. MHD-turbulence produced by the strong collisionless shocks could provide a sizeable non-thermal contribution to the observed Doppler parameter of the UV line spectra of the WHIM.Comment: 13 pages, 4 figures, accepted for publication in Space Science Reviews, special issue "Clusters of galaxies: beyond the thermal view", Editor J.S. Kaastra, Chapter 8; work done by an international team at the International Space Science Institute (ISSI), Bern, organised by J.S. Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke

On the similarity of dust flows in the inner coma of comets

The atmosphere of a comet is formed by the sublimation, due to solar illumination, of its volatile component and the dust particles ejected from its nucleus and entrained by the gas flow. Contemporary dusty-gas coma models take into account numerous physical processes occurring in the coma and a complex geometry of the nucleus. For the description of the dusty-gas flow in the coma, such models introduce a large number of governing parameters characterizing physical properties and processes. The relative role of these processes is not easy to ascribe therefore a relevant inter-comparison of model results becomes difficult. The present work introduces a set of universal, dimensionless parameters, which characterize the dust motion in the inner cometary coma. This approach allows one to: (i) reduce the number of parameters for analysis; (ii) reveal dust flows similarities; (iii) rescale the available numerical solutions. The present work demonstrates application of this approach to a realistic coma model. Description of dust motion with dimensionless parameters allows us to make a parametric study for a broad range of conditions and to find simple analytic approximations (via a polynomial function) of the numerical results suitable for rough estimations of dust density in the coma

Single impurity operators at critical wrapping order in the beta-deformed N=4 SYM

We study the spectrum of one single magnon in the superconformal beta-deformed N=4 SYM theory in the planar limit. We compute the anomalous dimensions of one-impurity operators O_{1,L}= tr(phi Z^{L-1}), including wrapping contributions at their critical order L.Comment: LaTeX, feynmf, Metapost, 20 pages, 11 figures, v2: results up to 11 loops completed, appendix on integral calculation extende

Complex therapy in Parkinson disease’ s patients: approaches and prospects

The review shows main kinds of Parkinson's disease treatment. There are main drugs for treatment motor and non­motor symptoms of this disease. The short characteristic of drugs has been shown in this review. There are various methods of non- medication treatment main symptoms of Parkinson’s disease. The review shows importance of complex, longitude therapy this patients at all levels of medical care. There are modem and high-technology methods of treatment in patients with Parkinson’s disease.В научном обзоре представлены основные направления терапии пациентов с болезнью Паркинсона. Освещены ведущие группы препаратов, используемые в лечении моторных и немоторных проявлений данной патологии. Дана краткая характеристика лекарственных средств. Перечислены возможные разнообразные методы немедикаментозной коррекции основных симптомов болезни Паркинсона. Указана важность комплексной непрерывной терапии пациентов с данной нозологией, а также необходимость преемственности терапии на различных этапах оказания медицинской помощи. Освещены современные, в том числе высокотехнологичные, методы лечения пациентов с болезнью Паркинсона