Incorporating radiation inputs into an operational snowmelt model

The primary snow accumulation and ablation model in the US National Weather Service streamflow prediction system is the temperature-based SNOW17 model. In this study, the SNOW17 snowpack heat exchange and melt subroutines are altered using a simplified energy balance approach, while the snow accumulation, water movement, and ground surface heat exchange processes of the SNOW17 are retained. The new model is referred to as the SNOW17 Energy Balance model (SNOW17-EB). Initial model development and testing was conducted with data from Reynold\u27s Creek Experimental Watershed (RCEW). The SNOW17-EB performed comparably to the SNOW17 in six years, but showed a tendency to over predict melt in at least 3 years. An ensemble of models were then created from the SNOW17 and the SNOW17-EB and combined within the Bayesian Model Averaging (BMA) framework. The BMA predictive mean and predictive variance were evaluated for six SNOTEL sites in the western U.S. The models performed best at the colder sites with high winter precipitation and little mid-winter melt. Model weights range from 0-58%, and at most sites all models received some weighting. Although, a single version of the SNOW17 often outperformed the BMA predictive mean, the ability to capture observed SWE within the 95% confidence intervals of the BMA variance was best at sites that gave more or equal weight to versions of the SNOW17-EB

Maternal Employment and Overweight Children

This paper investigates whether children are more or less likely to be overweight if their mothers work. The prevalence of both overweight children and working mothers has risen dramatically over the past few decades, although these parallel trends may be coincidental. The goal of this paper is to help determine whether a causal relationship exists between maternal employment and childhood overweight. To accomplish this, we mainly utilize matched mother/child data from the National Longitudinal Survey of Youth and employ three main econometric techniques, probit models, sibling difference models, and instrumental variables models in this analysis. Our results indicate that a child is more likely to be overweight if his/her mother worked more intensively (in the form of greater hours per week) over the child's life. This effect is particularly evident for children of white mothers, of mothers with more education, and of mothers with a high income level. Applying our estimates to the trend towards greater maternal employment indicates that the increased hours worked per week among mothers between 1975 and 1999 led to about a 0.4 to 0.7 percentage point increase in overweight children, which represents a relatively small share of the overall increase.

Maternal employment and overweight children

This paper seeks to determine whether a causal relationship exists between maternal employment and childhood overweight. We use matched mother/child data from the National Longitudinal Survey of Youth and employ econometric techniques to control for observable and unobservable differences across individuals and families that may influence both children's weight and their mothers' work patterns. Our results indicate that a child is more likely to be overweight if his/her mother worked more hours per week over the child's life. Analyses by subgroups show that it is higher socioeconomic status mothers whose work intensity is particularly deleterious for their children's overweight status.Employment (Economic theory) ; Overweight children

Economic perspectives on childhood obesity

Obesity rates in the U.S. have skyrocketed in the last 30 years. Among adults, obesity rates more than doubled from the early 1970s to the late 1990s. Children obesity rates nearly tripled over the same period. This article discusses why obesity is of interest from an economic perspective. It them examines changes in children's lives, particularly the increase in maternal employment, that may have contributed to increases in children's weight.Overweight children

KidsMatter for students with a disability: evaluation report

The KidsMatter Primary Mental Health Initiative is a whole of school framework that focuses on mental health care, the prevention of mental health problems and responding appropriately to mental health issue as they arise. The Australian initiative was originally designed for primary school children but has since been extended to early childhood as a separate initiative called KidsMatter Early Childhood.Upon completion of the Australia wide KidsMatter Evaluation, the data was examined to utilise information relating to students with a disability from South Australian primary schools. The analysis confirmed the previous findings of the Ministerial Advisory Committee that students with a disability are at significantly greater risk of developing mental health problems than students without a disability. The findings also suggest that KidsMatter Primary has had a positive effect on students with a disability by strengthening their wellbeing and reducing mental health difficulties

Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.

G-protein-coupled receptors are hyper-phosphorylated in a process that controls receptor coupling to downstream signaling pathways. The pattern of receptor phosphorylation has been proposed to generate a "bar code" that can be varied in a tissue-specific manner to direct physiologically relevant receptor signaling. If such a mechanism existed, receptors would be expected to be phosphorylated in a cell/tissue-specific manner. Using tryptic phosphopeptide maps, mass spectrometry, and phospho-specific antibodies, it was determined here that the prototypical G(q/11)-coupled M(3)-muscarinic receptor was indeed differentially phosphorylated in various cell and tissue types supporting a role for differential receptor phosphorylation in directing tissue-specific signaling. Furthermore, the phosphorylation profile of the M(3)-muscarinic receptor was also dependent on the stimulus. Full and partial agonists to the M(3)-muscarinic receptor were observed to direct phosphorylation preferentially to specific sites. This hitherto unappreciated property of ligands raises the possibility that one mechanism underlying ligand bias/functional selectivity, a process where ligands direct receptors to preferred signaling pathways, may be centered on the capacity of ligands to promote receptor phosphorylation at specific sites

Lofar Low-Band Antenna Observations of the 3C 295 and Bootes Fields: Source Counts and Ultra-Steep Spectrum Sources

We present Low Frequency Array (LOFAR) Low Band observations of the Boötes and 3C 295 fields. Our images made at 34, 46, and 62 MHz reach noise levels of 12, 8, and 5 mJy beam-1, making them the deepest images ever obtained in this frequency range. In t

Whole-genome sequencing illuminates the evolution and spread of multidrug-resistant tuberculosis in Southwest Nigeria.

Nigeria has an emerging problem with multidrug-resistant tuberculosis (MDR-TB). Whole-genome sequencing was used to understand the epidemiology of tuberculosis and genetics of multi-drug resistance among patients from two tertiary referral centers in Southwest Nigeria. In line with previous molecular epidemiology studies, most isolates of Mycobacterium tuberculosis from this dataset belonged to the Cameroon clade within the Euro-American lineage. Phylogenetic analysis showed this clade was undergoing clonal expansion in this region, and suggests that it was involved in community transmission of sensitive and multidrug-resistant tuberculosis. Five patients enrolled for retreatment were infected with pre-extensively drug resistant (pre-XDR) due to fluoroquinolone resistance in isolates from the Cameroon clade. In all five cases resistance was conferred through a mutation in the gyrA gene. In some patients, genomic changes occurred in bacterial isolates during the course of treatment that potentially led to decreased drug susceptibility. We conclude that inter-patient transmission of resistant isolates, principally from the Cameroon clade, contributes to the spread of MDR-TB in this setting, underscoring the urgent need to curb the spread of multi-drug resistance in this region

Assessing the bioactive profile of anti-fungal loaded calcium sulfate against fungal biofilms

Calcium sulfate (CS) has been used clinically as a bone or void filling biomaterial, and due to its resorptive properties have provided the prospect for its use as a release mechanism for local antibiotics to control biofilms. Here, we aimed to test CS beads loaded with three antifungal drugs against planktonic and sessile fungal species to assess whether these antifungal beads could be harnessed to provide consistent release of antifungals at biofilm inhibitive doses. A panel of different fungal species (n=15) were selected for planktonic broth microdilution testing with fluconazole (FLZ), amphotericin B (AMB) and caspofungin (CSP). After establishing planktonic inhibition, antifungal CS beads were introduced to fungal biofilms (n=5) to assess biofilm formation and cell viability through a combination of standard quantitative and qualitative biofilm assays. Inoculation of a hydrogel substrate, packed with antifungal CS beads, was also used to assess diffusion through a semi-dry material, to mimic active infection in-vivo. In general, antifungals released from CS loaded beads were all effective at inhibiting the pathogenic fungi over 7-days within standard MIC ranges for these fungi. We observed a significant reduction of pre-grown fungal biofilms across key fungal pathogens following treatment, with visually observable changes in cell morphology and biofilm coverage provided by scanning electron microscopy. Assessment of biofilm inhibition also revealed reductions in total and viable cells across all organisms tested. These data show that antifungal loaded CS beads produce a sustained antimicrobial effect, which inhibits and kills clinically relevant fungal species in-vitro as planktonic and biofilm cells

Performance evaluation of automated urine microscopy as a rapid, non-invasive approach for the diagnosis of non-gonococcal urethritis.

OBJECTIVES: Gram-stained urethral smear (GSUS), the standard point-of-care test for non-gonococcal urethritis (NGU) is operator dependent and poorly specific. The performance of rapid automated urine flow cytometry (AUFC) of first void urine (FVU) white cell counts (UWCC) for predicting Mycoplasma genitalium and Chlamydia trachomatis urethral infections was assessed and its application to asymptomatic infection was evaluated. METHODS: Receiver operating characteristic curve analysis, determining FVU-UWCC threshold for predicting M. genitalium or C. trachomatis infection was performed on 208 'training' samples from symptomatic patients and subsequently validated using 228 additional FVUs obtained from prospective unselected patients. RESULTS: An optimal diagnostic threshold of >29 UWC/µL gave sensitivities and specificities for either infection of 81.5% (95% CI 65.1% to 91.6%) and 85.8% (79.5% to 90.4%), respectively, compared with 86.8% (71.1% to 95%) and 64.7% (56.9% to 71.7%), respectively, for GSUS, using the training set samples. FVU-UWCC demonstrated sensitivities and specificities of 69.2% (95% CI 48.1% to 84.9%) and 92% (87.2% to 95.2%), respectively, when using validation samples. In asymptomatic patients where GSUS was not used, AUFC would have enabled more infections to be detected compared with clinical considerations only (71.4% vs 28.6%; p=0.03). The correlation between UWCC and bacterial load was stronger for M. genitalium compared with C. trachomatis (τ=0.426, p≤0.001 vs τ=0.295, p=0.022, respectively). CONCLUSIONS: AUFC offers improved specificity over microscopy for predicting C. trachomatis or M. genitalium infection. Universal AUFC may enable non-invasive diagnosis of asymptomatic NGU at the PoC. The degree of urethral inflammation exhibits a stronger association with pathogen load for M. genitalium compared with C. trachomatis