A Comparative Approach to Identifying the Irish in Long Eighteenth-Century London

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Historical Methods: A Journal of Quantitative and Interdisciplinary History', on 16 July 2015, available online: https://doi.org/10.1080/01615440.2015.1007194.Historians seeking to identify the Irish have overwhelmingly relied upon nominal record linkage, thus limiting studies to periods and contexts in which corroborating records exist. Surname analysis provides an alternative: a subset of 283 Irish surnames was able to correctly isolate 40 percent of known Irish individuals across thousands of entries, which is sufficient for sampling the Irish in demographic studies. This conclusion was based on an analysis of 278,949 names from the London area in the 1841 census, and was tested and refined against 42,248 historical records pertaining to the poor in London between 1777 and 1820.Peer reviewe

Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

Rheumatoid arthritis is an autoimmune disease characterized by hyperplasia of the synovial lining and destruction of cartilage and bone. Recent studies have suggested that a lack of apoptosis contributes to the hyperplasia of the synovial lining and to the failure in eliminating autoreactive cells. Mice lacking Fas or Bim, two pro-apoptotic proteins that mediate the extrinsic and intrinsic death cascades, respectively, develop enhanced K/BxN serum transfer-induced arthritis. Since the pro-apoptotic protein Bid functions as an intermediate between the extrinsic and intrinsic apoptotic pathways, we examined the role that it plays in inflammatory arthritis. Mice deficient in Bid (Bid-/-) show a delay in the resolution of K/BxN serum transfer-induced arthritis. Bid-/- mice display increased inflammation, bone destruction, and pannus formation compared to wild-type mice. Furthermore, Bid-/- mice have elevated levels of CXC chemokine and IL-1β in serum, which are associated with more inflammatory cells throughout the arthritic joint. In addition, there are fewer apoptotic cells in the synovium of Bid-/- compared to Wt mice. These data suggest that extrinsic and intrinsic apoptotic pathways cooperate through Bid to limit development of inflammatory arthritis