A Comparative Approach to Identifying the Irish in Long Eighteenth-Century London

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Historical Methods: A Journal of Quantitative and Interdisciplinary History', on 16 July 2015, available online: https://doi.org/10.1080/01615440.2015.1007194.Historians seeking to identify the Irish have overwhelmingly relied upon nominal record linkage, thus limiting studies to periods and contexts in which corroborating records exist. Surname analysis provides an alternative: a subset of 283 Irish surnames was able to correctly isolate 40 percent of known Irish individuals across thousands of entries, which is sufficient for sampling the Irish in demographic studies. This conclusion was based on an analysis of 278,949 names from the London area in the 1841 census, and was tested and refined against 42,248 historical records pertaining to the poor in London between 1777 and 1820.Peer reviewe

Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

Rheumatoid arthritis is an autoimmune disease characterized by hyperplasia of the synovial lining and destruction of cartilage and bone. Recent studies have suggested that a lack of apoptosis contributes to the hyperplasia of the synovial lining and to the failure in eliminating autoreactive cells. Mice lacking Fas or Bim, two pro-apoptotic proteins that mediate the extrinsic and intrinsic death cascades, respectively, develop enhanced K/BxN serum transfer-induced arthritis. Since the pro-apoptotic protein Bid functions as an intermediate between the extrinsic and intrinsic apoptotic pathways, we examined the role that it plays in inflammatory arthritis. Mice deficient in Bid (Bid-/-) show a delay in the resolution of K/BxN serum transfer-induced arthritis. Bid-/- mice display increased inflammation, bone destruction, and pannus formation compared to wild-type mice. Furthermore, Bid-/- mice have elevated levels of CXC chemokine and IL-1β in serum, which are associated with more inflammatory cells throughout the arthritic joint. In addition, there are fewer apoptotic cells in the synovium of Bid-/- compared to Wt mice. These data suggest that extrinsic and intrinsic apoptotic pathways cooperate through Bid to limit development of inflammatory arthritis

Ghettos of the mind: the empirical behaviour of indices of segregation and diversity

The effect of immigration on social cohesion is a political issue, expressed as a fear that racially skewed residential patterns represent ghettos which prevent integration. Residential patterns have been measured by indices of segregation. The range of indices is reviewed in the paper and measured empirically for England and Wales by using census data for 1991 and 2001, including a new index of migration dispersal. There has been an increase in residential mixing as a result of growing minority populations and their more even spread across localities. These two trends are identified by two commonly used indices of segregation which are moving in opposite directions for the most recent immigrant groups. The sensitivity of each index to modifiable area boundaries makes them unsuitable for evaluation of cities' relative performance. The residential patterns of cities after immigration are more clearly understood by using demographic measures of migration and age structure. Copyright 2007 Royal Statistical Society.