The Science and Technology of Particle Accelerators

The Science and Technology of Particle Accelerators provides an accessible introduction to the field, and is suitable for advanced undergraduates, graduate students, and academics, as well as professionals in national laboratories and facilities, industry, and medicine who are designing or using particle accelerators. Providing integrated coverage of accelerator science and technology, this book presents the fundamental concepts alongside detailed engineering discussions and extensive practical guidance, including many numerical examples. For each topic, the authors provide a description of the physical principles, a guide to the practical application of those principles, and a discussion of how to design the components that allow the application to be realised. Features: Written by an interdisciplinary and highly respected team of physicists and engineers from the Cockcroft Institute of Accelerator Science and Technology in the UK Accessible style, with many numerical examples Contains an extensive set of problems, with fully worked solutions available Rob Appleby is an academic member of staff at the University of Manchester, and Chief Examiner in the Department of Physics and Astronomy. Graeme Burt is an academic member of staff at the University of Lancaster, and previous Director of Education at the Cockcroft Institute. James Clarke is head of Science Division in the Accelerator Science and Technology Centre at STFC Daresbury Laboratory. Hywel Owen is an academic member of staff at the University of Manchester, and Director of Education at the Cockcroft Institute. All authors are researchers within the Cockcroft Institute of Accelerator Science and Technology and have extensive experience in the design and construction of particle accelerators, including particle colliders, synchrotron radiation sources, free electron lasers, and medical and industrial accelerator systems

The Science and Technology of Particle Accelerators

The Science and Technology of Particle Accelerators provides an accessible introduction to the field, and is suitable for advanced undergraduates, graduate students, and academics, as well as professionals in national laboratories and facilities, industry, and medicine who are designing or using particle accelerators. Providing integrated coverage of accelerator science and technology, this book presents the fundamental concepts alongside detailed engineering discussions and extensive practical guidance, including many numerical examples. For each topic, the authors provide a description of the physical principles, a guide to the practical application of those principles, and a discussion of how to design the components that allow the application to be realised. Features: Written by an interdisciplinary and highly respected team of physicists and engineers from the Cockcroft Institute of Accelerator Science and Technology in the UK Accessible style, with many numerical examples Contains an extensive set of problems, with fully worked solutions available Rob Appleby is an academic member of staff at the University of Manchester, and Chief Examiner in the Department of Physics and Astronomy. Graeme Burt is an academic member of staff at the University of Lancaster, and previous Director of Education at the Cockcroft Institute. James Clarke is head of Science Division in the Accelerator Science and Technology Centre at STFC Daresbury Laboratory. Hywel Owen is an academic member of staff at the University of Manchester, and Director of Education at the Cockcroft Institute. All authors are researchers within the Cockcroft Institute of Accelerator Science and Technology and have extensive experience in the design and construction of particle accelerators, including particle colliders, synchrotron radiation sources, free electron lasers, and medical and industrial accelerator systems

Constraining the Carbon Budget of Peat Ecosystems: Application of Stoichiometry and Enthalpy Balances

We consider how the stoichiometry and energy content of organic matter reservoirs and fluxes through and from a peatland enable the fluxes and storage of carbon within a peatland to be constrained. We include the elemental composition of the above- and below-ground biomass, litter, the peat profile, and the dissolved and particulate organic matter within a blanket bog in northern England for which the C budget has previously been measured. The study shows, based only on the elemental composition, and calculation of oxidation and energy contents, that: (a) Dissolved organic carbon (DOC) in first-order streams is significantly more oxidized than in peat pore water but that there was no significant difference in organic carbon oxidation state down the peat profile; (b) The occurrence and speciation of N uptake and release in the peatland with N used and recycled can be predicted; (c) The relatively high oxidation state of DOC in stream water acts as an endpoint for peat-forming reactions; (d) Methanogenesis does not result in deep peat formation as its requirement for energy consumes too much organic matter to form residual peat at depth; (e) Sulfate reduction does occur during the formation of deep peat; (f) Organic matter elemental composition could be constrained to within three bounding equations though the proportions of carbon species could not be specified. (g) The formation of deep peat in this catchment could only be achieved if the dissolved organic matter (DOM) in the peat pore water is the dominant electron acceptor and energy source in the production of residual organic matter; however, it is unclear as to the flux of DOM up or down the peat profile

An Assessment of Engineering Students' Curricular and Co‐Curricular Experiences and Their Ethical Development

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95194/1/j.2168-9830.2012.tb00058.x.pd

Agribusiness Sheep Updates - 2004 part 3

Posters Can Merino Ewes be Teased to Synchronise Oestrus for a Summer/Autumn Mating? Ken Hart, Keith Croker, Department of Agriculture Western Australia, Rob Davidson, School of Animal Biology, University of Western Australia. Mario D\u27Antuono, Department of Agriculture Western Australia Damara Sheep: Now Looking Domestic Evan Burt and Tanya Kilminster, Department of Agriculture Western Australia Production and Water Use of Lucerne and French Serradella Under Three Sowing Rates Diana Fedorenko1,4, Darryl McClements1,4 , Robert Beard3,4 1Department of Agriculture, 3 Farmer, Meckering, 4CRC for Plant-based Management of Dryland Salinity. E-SHEEP - Individual Animal Management is here Sandy Turton & Martin Atwell, Department of Agriculture, Western Australia. Using Radio Frequency Identification Technology on Farm Martin Atwell & Sandy Turton, Department of Agriculture, Western Australia The Impact of Introducing Lucerne into a Wheat / Sheep Farming System on Wool and Meat Production Robert Beard1,3 and Diana Fedorenko2,3. 1Farmer, Meckering; 2Department of Agriculture, Western Australia, 3CRC for Plant-based Management of Dryland Salinit

TESS Discovery of a Transiting Super-Earth in the π\pi Mensae System

We report the detection of a transiting planet around $\pi$ Mensae (HD 39091), using data from the Transiting Exoplanet Survey Satellite (TESS). The solar-type host star is unusually bright (V=5.7) and was already known to host a Jovian planet on a highly eccentric, 5.7-year orbit. The newly discovered planet has a size of $2.04\pm 0.05$ $R_\oplus$ and an orbital period of 6.27 days. Radial-velocity data from the HARPS and AAT/UCLES archives also displays a 6.27-day periodicity, confirming the existence of the planet and leading to a mass determination of $4.82\pm 0.85$ $M_\oplus$. The star's proximity and brightness will facilitate further investigations, such as atmospheric spectroscopy, asteroseismology, the Rossiter--McLaughlin effect, astrometry, and direct imaging.Comment: Accepted for publication ApJ Letters. This letter makes use of the TESS Alert data, which is currently in a beta test phase. The discovery light curve is included in a table inside the arxiv submissio

Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells

Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against acute myeloid leukemia in early phase trials. However, other than activation of the integrated stress response, the downstream effects of GSPT1 degradation leading to cell death are largely undefined, and no murine models are available to study these agents. We identified the domains of GSPT1 essential for cell survival and show that GSPT1 degradation leads to impaired translation termination, activation of the integrated stress response pathway, and TP53-independent cell death. CRISPR-Cas9 screens implicated decreased translation initiation as protective to GSPT1 degradation, suggesting that cells with higher levels of translation are more susceptible to GSPT1 degradation. We defined two Crbn amino acids that prevent Gspt1 degradation in mice, generated a knock-in mouse with alteration of these residues, and demonstrated the efficacy of GSPT1-degrading drugs in vivo with relative sparing of numbers and function of long-term hematopoietic stem cells. Our results provide a mechanistic basis for the use of GSPT1 degraders for the treatment of cancer, including TP53-mutant AML

Developing a community-based genetic nomenclature for anole lizards

Background: Comparative studies of amniotes have been hindered by a dearth of reptilian molecular sequences. With the genomic assembly of the green anole, Anolis carolinensis available, non-avian reptilian genes can now be compared to mammalian, avian, and amphibian homologs. Furthermore, with more than 350 extant species in the genus Anolis, anoles are an unparalleled example of tetrapod genetic diversity and divergence. As an important ecological, genetic and now genomic reference, it is imperative to develop a standardized Anolis gene nomenclature alongside associated vocabularies and other useful metrics. Results: Here we report the formation of the Anolis Gene Nomenclature Committee (AGNC) and propose a standardized evolutionary characterization code that will help researchers to define gene orthology and paralogy with tetrapod homologs, provide a system for naming novel genes in Anolis and other reptiles, furnish abbreviations to facilitate comparative studies among the Anolis species and related iguanid squamates, and classify the geographical origins of Anolis subpopulations. Conclusions: This report has been generated in close consultation with members of the Anolis and genomic research communities, and using public database resources including NCBI and Ensembl. Updates will continue to be regularly posted to new research community websites such as lizardbase. We anticipate that this standardized gene nomenclature will facilitate the accessibility of reptilian sequences for comparative studies among tetrapods and will further serve as a template for other communities in their sequencing and annotation initiatives.Organismic and Evolutionary BiologyOther Research Uni

<i>TESS</i> Spots a Compact System of Super-Earths around the Naked-eye Star HR 858

Transiting Exoplanet Survey Satellite (TESS) observations have revealed a compact multiplanet system around the sixth-magnitude star HR 858 (TIC 178155732, TOI 396), located 32 pc away. Three planets, each about twice the size of Earth, transit this slightly evolved, late F-type star, which is also a member of a visual binary. Two of the planets may be in mean motion resonance. We analyze the TESS observations, using novel methods to model and remove instrumental systematic errors, and combine these data with follow-up observations taken from a suite of ground-based telescopes to characterize the planetary system. The HR 858 planets are enticing targets for precise radial velocity observations, secondary eclipse spectroscopy, and measurements of the Rossiter–McLaughlin effect