Bostonia. Volume 4

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Solitons from Dressing in an Algebraic Approach to the Constrained KP Hierarchy

The algebraic matrix hierarchy approach based on affine Lie $sl (n)$ algebras leads to a variety of 1+1 soliton equations. By varying the rank of the underlying $sl (n)$ algebra as well as its gradation in the affine setting, one encompasses the set of the soliton equations of the constrained KP hierarchy. The soliton solutions are then obtained as elements of the orbits of the dressing transformations constructed in terms of representations of the vertex operators of the affine $sl (n)$ algebras realized in the unconventional gradations. Such soliton solutions exhibit non-trivial dependence on the KdV (odd) time flows and KP (odd and even) time flows which distinguishes them from the conventional structure of the Darboux-B\"{a}cklund Wronskian solutions of the constrained KP hierarchy.Comment: LaTeX, 13pg

Combinatorial Hopf algebras and Towers of Algebras

Bergeron and Li have introduced a set of axioms which guarantee that the Grothendieck groups of a tower of algebras $\bigoplus_{n\ge0}A_n$ can be endowed with the structure of graded dual Hopf algebras. Hivert and Nzeutzhap, and independently Lam and Shimozono constructed dual graded graphs from primitive elements in Hopf algebras. In this paper we apply the composition of these constructions to towers of algebras. We show that if a tower $\bigoplus_{n\ge0}A_n$ gives rise to graded dual Hopf algebras then we must have $\dim(A_n)=r^nn!$ where $r = \dim(A_1)$.Comment: 7 page

Nonstandard Drinfeld-Sokolov reduction

Subject to some conditions, the input data for the Drinfeld-Sokolov construction of KdV type hierarchies is a quadruplet (\A,\Lambda, d_1, d_0), where the $d_i$ are $\Z$-gradations of a loop algebra \A and \Lambda\in \A is a semisimple element of nonzero $d_1$-grade. A new sufficient condition on the quadruplet under which the construction works is proposed and examples are presented. The proposal relies on splitting the $d_1$-grade zero part of \A into a vector space direct sum of two subalgebras. This permits one to interpret certain Gelfand-Dickey type systems associated with a nonstandard splitting of the algebra of pseudo-differential operators in the Drinfeld-Sokolov framework.Comment: 19 pages, LaTeX fil

Regular Conjugacy Classes in the Weyl Group and Integrable Hierarchies

Generalized KdV hierarchies associated by Drinfeld-Sokolov reduction to grade one regular semisimple elements from non-equivalent Heisenberg subalgebras of a loop algebra \G\otimes{\bf C}[\lambda,\lambda^{-1}] are studied. The graded Heisenberg subalgebras containing such elements are labelled by the regular conjugacy classes in the Weyl group {\bf W}(\G) of the simple Lie algebra \G. A representative w\in {\bf W}(\G) of a regular conjugacy class can be lifted to an inner automorphism of \G given by $\hat w=\exp\left(2i\pi {\rm ad I_0}/m\right)$, where $I_0$ is the defining vector of an $sl_2$ subalgebra of \G.The grading is then defined by the operator $d_{m,I_0}=m\lambda {d\over d\lambda} + {\rm ad} I_0$ and any grade one regular element $\Lambda$ from the Heisenberg subalgebra associated to $[w]$ takes the form $\Lambda = (C_+ +\lambda C_-)$, where $[I_0, C_-]=-(m-1) C_-$ and $C_+$ is included in an $sl_2$ subalgebra containing $I_0$. The largest eigenvalue of ${\rm ad}I_0$ is $(m-1)$ except for some cases in $F_4$, $E_{6,7,8}$. We explain how these Lie algebraic results follow from known results and apply them to construct integrable systems.If the largest ${\rm ad} I_0$ eigenvalue is $(m-1)$, then using any grade one regular element from the Heisenberg subalgebra associated to $[w]$ we can construct a KdV system possessing the standard \W-algebra defined by $I_0$ as its second Poisson bracket algebra. For \G a classical Lie algebra, we derive pseudo-differential Lax operators for those non-principal KdV systems that can be obtained as discrete reductions of KdV systems related to $gl_n$. Non-abelian Toda systems are also considered.Comment: 44 pages, ENSLAPP-L-493/94, substantial revision, SWAT-95-77. (use OLATEX (preferred) or LATEX

Generalized Drinfeld-Sokolov Reductions and KdV Type Hierarchies

Generalized Drinfeld-Sokolov (DS) hierarchies are constructed through local reductions of Hamiltonian flows generated by monodromy invariants on the dual of a loop algebra. Following earlier work of De Groot et al, reductions based upon graded regular elements of arbitrary Heisenberg subalgebras are considered. We show that, in the case of the nontwisted loop algebra $\ell(gl_n)$, graded regular elements exist only in those Heisenberg subalgebras which correspond either to the partitions of $n$ into the sum of equal numbers $n=pr$ or to equal numbers plus one $n=pr+1$. We prove that the reduction belonging to the grade $1$ regular elements in the case $n=pr$ yields the $p\times p$ matrix version of the Gelfand-Dickey $r$-KdV hierarchy, generalizing the scalar case $p=1$ considered by DS. The methods of DS are utilized throughout the analysis, but formulating the reduction entirely within the Hamiltonian framework provided by the classical r-matrix approach leads to some simplifications even for $p=1$.Comment: 43 page

PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients

Background: The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use of anti-PD-L1/PD-1 antibodies in multiple myeloma (MM) patients still remains debated, at least in part because of discordant literature data on PD-L1/PD-1 expression by MM cells and bone marrow (BM) microenvironment cells. The unmet need to identify patients which could benefit from this therapeutic approach prompts us to evaluate the BM expression profile of PD-L1/PD-1 axis across the different stages of the monoclonal gammopathies. Methods: The PD-L1/PD-1 axis was evaluated by flow cytometry in the BM samples of a total cohort of 141 patients with monoclonal gammopathies including 24 patients with Monoclonal Gammopathy of Undetermined Significance (MGUS), 38 patients with smoldering MM (SMM), and 79 patients with active MM, including either newly diagnosed or relapsed-refractory patients. Then, data were correlated with the main immunological and clinical features of the patients. Results: First, we did not find any significant difference between MM and SMM patients in terms of PD-L1/PD-1 expression, on both BM myeloid (CD14+) and lymphoid subsets. On the other hand, PD-L1 expression by CD138+ MM cells was higher in both SMM and MM as compared to MGUS patients. Second, the analysis on the total cohort of MM and SMM patients revealed that PD-L1 is expressed at higher level in CD14+CD16+ non-classical monocytes compared with classical CD14+CD16− cells, independently from the stage of disease. Moreover, PD-L1 expression on CD14+ cells was inversely correlated with BM serum levels of the anti-tumoral cytokine, IL-27. Interestingly, relapsed MM patients showed an inverted CD4+/CD8+ ratio along with high levels of pro-tumoral IL-6 and a positive correlation between Í14+PD-L1+ and Í8+PD-1+ cells as compared to both SMM and newly diagnosed MM patients suggesting a highly compromised immune-compartment with low amount of CD4+ effector cells. Conclusions: Our data indicate that SMM and active MM patients share a similar PD-L1/PD-1 BM immune profile, suggesting that SMM patients could be an interesting target for PD-L1/PD-1 inhibition therapy, in light of their less compromised and more responsive immune-compartment

Extensions of the matrix Gelfand-Dickey hierarchy from generalized Drinfeld-Sokolov reduction

The $p\times p$ matrix version of the $r$-KdV hierarchy has been recently treated as the reduced system arising in a Drinfeld-Sokolov type Hamiltonian symmetry reduction applied to a Poisson submanifold in the dual of the Lie algebra $\widehat{gl}_{pr}\otimes {\Complex}[\lambda, \lambda^{-1}]$. Here a series of extensions of this matrix Gelfand-Dickey system is derived by means of a generalized Drinfeld-Sokolov reduction defined for the Lie algebra $\widehat{gl}_{pr+s}\otimes {\Complex}[\lambda,\lambda^{-1}]$ using the natural embedding $gl_{pr}\subset gl_{pr+s}$ for $s$ any positive integer. The hierarchies obtained admit a description in terms of a $p\times p$ matrix pseudo-differential operator comprising an $r$-KdV type positive part and a non-trivial negative part. This system has been investigated previously in the $p=1$ case as a constrained KP system. In this paper the previous results are considerably extended and a systematic study is presented on the basis of the Drinfeld-Sokolov approach that has the advantage that it leads to local Poisson brackets and makes clear the conformal ($\cal W$-algebra) structures related to the KdV type hierarchies. Discrete reductions and modified versions of the extended $r$-KdV hierarchies are also discussed.Comment: 60 pages, plain TE