Tris(2-amino­pyridinium) hexa­chlorido­indate(III)

The Schiff base (E)-4-chloro-2-[(pyridin-2-yl­imino)­meth­yl]phenol was reacted with InCl3·4H2O, generating the title molecular salt, (C5H7N2)3[InCl6]. The octa­hedral hexa­chlorido­indate(III) anion is located on an inversion centre, and one half of the anion and two crystallographically independent cations form the asymmetric unit. One of the cations is located on a twofold rotation axis and its intra-ring C and N atoms simulate this symmetry by exchanging their positions in statistical disorder. In the crystal, weak N—H⋯Cl hydrogen bonds and two types of π–π interactions with centroid–centroid separations of 4.047 (3) and 4.202 (3) Å are observed

Relevant aspects of the professional development of medical specialists of middle level (literature review)

The article presents a review of the scientific literature on continuing medical education of mid-level professionals for the last 9 years, reflects the domestic and foreign experience of improving the General knowledge and professional competencies. The role of scientific research in nursing care for the professional development of specialists was actualized.В статье представлен обзор научной литературы по вопросам непрерывного медицинского образования специалистов среднего звена за последние 8 лет, отражен отечественный и зарубежный опыт совершенствования знаний, общих и профессиональных компетенций. Актуализирована роль научных исследований в сестринском деле для профессионального развития специалистов

The appearance of molecules of prothrombin origin in blood upon development of atherothrombotic and cardioembolic ischemic stroke

Increase of molecules of prothrombin origin in patients with atherothrombotic and cardioembolic stroke subtypes had been shown. It was found the presence of protein fractions in the range of molecular weights corresponding to both prothrombin molecules and its degraded forms

Assessment results professional development of medical specialists of an average link

In article the substantiation of the method of formalized individual assessment of results of professional development of medical specialists of an average link was given. Systematic multi-factor data analysis of the test survey, characterizing the level of development of additional professional programs, educational activity of specialist was conducted. The values of integral indicators, of influence coefficient, determining the most significant factors for the development of continuing medical education and a particular specialist in particular were obtained.В статье приведено обоснование формализованного метода индивидуальной оценки результатов профессионального развития медицинских специалистов среднего звена. Выполнен системный многофакторный анализ данных тест-опроса, характеризующего уровень освоения дополнительных профессиональных программ, образовательной активности специалиста. Получены значения интегральных показателей, коэффициентов влияния, определяющих наиболее значимые факторы развития системы непрерывного медицинского образования и конкретного специалиста в частности

Specific of treating elderly patients with coronary heart disease and alexithymia

Recently investigators' attention has been focused on searching psychological and behavioural risk factors for coronary heart disease (CHD), and on perspectives of their modification in primary and secondary CHD prevention. The study included 147 patients with stable effort angina (functional class II-III) older than 55. The main criterion for diagnosing alexithymia and dividing participants into groups was the score greater than 74, by Toronto Alexithymia Scale. All participants were divided into three groups. Group 1 included patients with alexithymia, who received basic treatment for effort angina, together with two-week course of melatonin (M). Group II consisted of alexithymia patients not receiving M. Group III included alexithymia-free patients receiving basic therapy and M. After two weeks of combined M treatment, a significant improvement of all assessed psychological and objective parameters was observed

Criteria of endogenous intoxication in patients with atherothrombotic ischemic stroke and cardioembolic ischemic stroke

To determine the concentration of IgG, the level of middle mass molecules and oligopeptides in blood plasma of patients with atherothrombotic and cardioembolic ischemic stroke. The study involved 122 patients diagnosed with atherothrombotic and cardioembolic ischemic stroke and 40 relatively healthy donors. The concentration of IgG was determined by affinity chromatography on protein A sepharose. The level of oligopeptides and middle mass molecules were determined by methods described by Nikolaichyk V. and co-authors. IgG concentration increased with the development of cardioembolic ischemic stroke, reaching 10,7±0,97 mg/ml on the 14th day, while on admission to hospital was 5,0±0,35 mg/ml. For atherothrombotic ischemic stroke the level of middle mass molecules in the plasma was 3.35 times higher, while the level of oligopeptides was 3.6 times higher relative to donors. Cardioembolic ischemic stroke was accompanied by 2.6 times higher level of middle mass molecules and by 2.5 times higher level of oligopeptides relative to donors. Cardioembolic ischemic stroke was accompanied by 2 times higher concentration of IgG in plasma on the 14th day of desease relative to the rate specified on admission to hospital. For both subtypes of ischemic stroke an increase in middle mass molecules and oligopeptides was observed, indicating the activation of proteolytic processes in the organism

Article A Practical Synthesis of Betulonic Acid Using Selective Oxidation of Betulin on Aluminium Solid Support

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