Valutazione dell’accessibilità con software open source

L'accessibilità ha da sempre ricoperto un ruolo fondamentale per lo sviluppo delle società e per rendere sempre più agevoli gli spostamenti, a prescindere dalle cause che li originano. In questo articolo si vuole focalizzare l’attenzione sull’accessibilità ai terminal aeroportuali, in quanto la velocità e la facilità di accesso sono aspetti strategici per il trasporto aereo. Se il tempo di accesso ai terminal non fosse sufficientemente rapido, negli spostamenti a breve distanza, l’aereo perderebbe il vantaggio che ha sulle altre scelte modali. Lo scopo che ci si è posti nella ricerca è di valutare l’accessibilità territoriale attraverso l’uso di software GIS (Geographic Information System) open source. Per validare il metodo si è condotta un’applicazione sulle infrastrutture aeroportuali siciliane. A tal fine è stato preliminarmente necessario analizzare la rete stradale siciliana, per creare un quadro generale che ha permesso di mettere in evidenza il grado di accessibilità che caratterizza i tre principali aeroporti dell’isola: · Falcone Borsellino di Palermo-Punta Raisi, · Vincenzo Bellini di Catania-Fontanarossa, · Vincenzo Florio di Trapani-Birgi. Lo studio si è concentrato sulle misure topologiche dell’accessibilità, che esprimono la raggiungibilità di un sito in funzione delle connessioni offerte dal sistema di trasporti. È stata, quindi, considerata l’accessibilità passiva a partire da tutti i comuni siciliani verso i terminal aeroportuali in termini di tempo. Tale misura può essere rappresentata da curve isocrone, che permettono di determinare il numero di destinazioni potenziali che possono essere raggiunte in un prefissato intervallo di tempo di viaggio. Questa misura non tiene conto della percezione degli individui e delle loro preferenze; ciò implica che tutte le opportunità sono egualmente desiderabili con riferimento al tempo di viaggio o al tipo di opportunità. Le isocrone sono state tracciate per testare il potenziale della rete stradale a vuoto e sotto l’ipotesi semplificativa che l’offerta dei tre aeroporti, in termini di voli disponibili, sia uguale

Innovative transport services in areas with weak and peculiar public transport demand

A growing demand for mobility and the deficiencies in the transport system have transformed urban centres in “unliveable” places. A prevalent use of private cars produces high levels of pollution, casualties and road congestion. The promotion of public transport is considered an effective strategy to make mobility more sustainable for people. When a public transport system serves areas with a weak transportation demand, as it happens in territories with dispersed settlements (urban outskirts, rural areas, mountains, …), the resort to unconventional forms of public transport, such as dial and ride bus services, is necessary

The analysis of urban travellers' latent preferences to explain their mode choice behaviour.

Our research aims to explore the impact of latent variables, mirroring urban travellers’ attitudes and perceptions, on the individual decision making process regarding the mode of transport. The paper describes the first results of an ongoing research activity, which derive from a pilot study conducted in Palermo, the capital of the Sicilian Region (in the south of Italy), and demonstrate that policy makers, in designing a socially desirable and environmentally sustainable urban mobility system, should take into account how travellers perceive the qualitative dimensions of transport

Alpha-fetoprotein surge following high-dose chemotherapy in germ cell tumours

In patients with non-seminomatous germ cell tumours (NSGCTs) who receive chemotherapy and have residual disease, a persistently elevated serum marker level after induction chemotherapy indicates active and progressive disease. High-dose chemotherapy (HDCT) is the standard treatment for patients with relapsed NSGCT. We present a case of a patient with residual disease from NSGCT who showed an increase in serum alpha-fetoprotein levels after HDCT, mimicking progression. Resection of the mass did not show viable cells in the tumour specimen, thus suggesting that the elevated level of the marker was expression of hepatic reconstitution after drug-induced liver damage. HDCT is increasingly used in cases of relapsed NSGCT, and the possibility of treatment-induced alpha-fetoprotein elevation must be taken into account in patient management. © 2013 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia

Rationale and design of MILES-3 and MILES-4 studies: two randomized phase III trials comparing single-agent chemotherapy versus cisplatin-based doublets in elderly patients with advanced non-small cell lung cancer

BACKGROUND: Platinum-based chemotherapy is the cornerstone of treatment of advanced non-small-cell lung cancer (NSCLC) patients, but the efficacy of adding cisplatin to single-agent chemotherapy remains to be demonstrated in prospective phase III trials dedicated to elderly patients. Furthermore, the superiority of cisplatin/pemetrexed over cisplatin/gemcitabine in non-squamous NSCLC has not been confirmed prospectively. We present the rationale and design of two open-label, multicenter, randomized phase III trials for elderly patients with advanced NSCLC∶ Multicenter Italian Lung cancer in the Elderly Study (MILES)-3 and MILES-4. The aim is to evaluate the efficacy of adding cisplatin to single-agent chemotherapy (both trials) and the efficacy of pemetrexed versus gemcitabine in non-squamous tumors (MILES-4). PATIENTS AND METHODS: Both trials are dedicated to first-line therapy of patients older than 70 years with advanced NSCLC, ECOG performance status 0-1. In the MILES-3 trial, patients are randomized in a 1∶1 ratio to gemcitabine or cisplatin/gemcitabine. In the MILES-4 study patients with non-squamous histology are randomized, in a factorial design with 1∶1∶1∶1 ratio, to four arms: gemcitabine (A), cisplatin/gemcitabine (B), pemetrexed (C), cisplatin/pemetrexed (D). Two comparisons are planned∶ A+C vs B+D to test the role of cisplatin; A+B vs C+D to test the role of pemetrexed. Primary endpoint of both trials is overall survival. Secondary and exploratory endpoints include progression-free survival, response rate, toxicity, and quality of life. CONCLUSIONS: MILES-3 and MILES-4 results will add important evidence about the role of cisplatin-based doublets and pemetrexed in the first-line therapy of elderly patients with advanced NSCLC

Science case study and scientific simulations for the enhanced X-ray Timing Polarimetry mission, eXTP

The X-ray astronomy mission eXTP (enhanced X-ray Timing Polarimetry) is designed to study matter under extreme conditions of density, gravity and magnetism. Primary goals are the determination of the equation of state (EoS) of matter at supranuclear density, the physics in extremely strong magnetic fields, the study of accretion in strong-field gravity (SFG) regime. Primary targets include isolated and binary neutron stars, strong magneticfield systems like magnetars, and stellar-mass and supermassive black holes. In this paper we report about key observations and simulations with eXTP on the primary objectives involving accretion under SFG regimes and determination of NS-Eo