309 research outputs found
Kahler Moduli Inflation
We show that under general conditions there is at least one natural
inflationary direction for the Kahler moduli of type IIB flux
compactifications. This requires a Calabi-Yau which has h^{2,1}>h^{1,1}>2 and
for which the structure of the scalar potential is as in the recently found
exponentially large volume compactifications. We also need - although these
conditions may be relaxed - at least one Kahler modulus whose only
non-vanishing triple-intersection is with itself and which appears by itself in
the non-perturbative superpotential. Slow-roll inflation then occurs without a
fine tuning of parameters, evading the eta problem of F-term inflation. In
order to obtain COBE-normalised density perturbations, the stabilised volume of
the Calabi-Yau must be O(10^5-10^7) in string units, and the inflationary scale
M_{infl} ~ 10^{13} GeV. We find a robust model independent prediction for the
spectral index of 1 - 2/N_e = 0.960 - 0.967, depending on the number of
efoldings.Comment: 17 pages, 1 figure; v2. references adde
Chornobyl radiation spikes are not due to military vehicles disturbing soil
On 25th February 2022, increased gamma radiation dose rates were reported within the Chornobyl Exclusion Zone (CEZ). This coincided with Russian military vehicles entering the Ukrainian part of the CEZ from neighbouring Belarus. It was speculated that contaminated soil resuspension by vehicle movements or a leak from the Chornobyl Nuclear Power Plant complex may explain these spikes in radiation dose rates. The gamma dose rate monitoring network in the CEZ provides a crucial early warning system for releases of radioactivity to the environment and is part of the international safeguards for nuclear facilities. With the potential for further military action in the CEZ and concerns over nuclear safety, it is essential that such anomalous readings are investigated. We evaluate the hypotheses suggested to explain the apparent gamma dose rate increases, demonstrating that neither military vehicle-induced soil resuspension nor a leak from the Chornobyl Nuclear Power Plant are plausible. However, disruption of the Chornobyl base-station's reception of wireless signals from the gamma dose rate monitoring network in the CEZ may potentially explain the dose rate increases recorded
Brane Interaction as the Origin of Inflation
We reanalyze brane inflation with brane-brane interactions at an angle, which
include the special case of brane-anti-brane interaction. If nature is
described by a stringy realization of the brane world scenario today (with
arbitrary compactification), and if some additional branes were present in the
early universe, we find that an inflationary epoch is generically quite
natural, ending with a big bang when the last branes collide. In an interesting
brane inflationary scenario suggested by generic string model-building, we use
the density perturbation observed in the cosmic microwave background and the
coupling unification to find that the string scale is comparable to the GUT
scale.Comment: 28 pages, 8 figures, 2 tables, JHEP forma
On the evolution of cosmic-superstring networks
We model the behaviour of a network of interacting (p,q) strings from IIB
string theory by considering a field theory containing multiple species of
string, allowing us to study the effect of non-intercommuting events due to two
different species crossing each other. This then has the potential for a string
dominated Universe with the network becoming so tangled that it freezes. We
give numerical evidence, explained by a one-scale model, that such freezing
does not take place, with the network reaching a scaling limit where its
density relative to the background increases with N, the number of string
types.Comment: Extra references added showing constraints on cosmic superstrings, 7
pages, 7 figure
Extracting W Boson Couplings from the Production of Four Leptons
We consider the processes , including all possible charged lepton combinations, with
regard to measuring parameters characterizing the boson. We calculate at
what level these processes can be used to measure anamolous triple-boson
vertice coupling parameters for the cases of colliders at 500
and 1 center of mass energies.Comment: 13 pages,OCIP/C-93-
Chornobyl radiation spikes are not due to military vehicles disturbing soil
On 25th February 2022, increased gamma radiation dose rates were reported within the Chornobyl Exclusion Zone (CEZ). This coincided with Russian military vehicles entering the Ukrainian part of the CEZ from neighbouring Belarus. It was speculated that contaminated soil resuspension by vehicle movements or a leak from the Chornobyl Nuclear Power Plant complex may explain these spikes in radiation dose rates. The gamma dose rate monitoring network in the CEZ provides a crucial early warning system for releases of radioactivity to the environment and is part of the international safeguards for nuclear facilities. With the potential for further military action in the CEZ and concerns over nuclear safety, it is essential that such anomalous readings are investigated. We evaluate the hypotheses suggested to explain the apparent gamma dose rate increases, demonstrating that neither military vehicle-induced soil resuspension nor a leak from the Chornobyl Nuclear Power Plant are plausible. However, disruption of the Chornobyl base-station's reception of wireless signals from the gamma dose rate monitoring network in the CEZ may potentially explain the dose rate increases recorded
Low-Energy Supersymmetry Breaking from String Flux Compactifications: Benchmark Scenarios
Soft supersymmetry breaking terms were recently derived for type IIB string
flux compactifications with all moduli stabilised. Depending on the choice of
the discrete input parameters of the compactification such as fluxes and ranks
of hidden gauge groups, the string scale was found to have any value between
the TeV and GUT scales. We study the phenomenological implications of these
compactifications at low energy. Three realistic scenarios can be identified
depending on whether the Standard Model lies on D3 or D7 branes and on the
value of the string scale. For the MSSM on D7 branes and the string scale
between 10^12 GeV and 10^17 GeV we find that the LSP is a neutralino, while for
lower scales it is the stop. At the GUT scale the results of the fluxed MSSM
are reproduced, but now with all moduli stabilised. For the MSSM on D3 branes
we identify two realistic scenarios. The first one corresponds to an
intermediate string scale version of split supersymmetry. The second is a
stringy mSUGRA scenario. This requires tuning of the flux parameters to obtain
the GUT scale. Phenomenological constraints from dark matter, (g-2)_mu and
BR(b->s gamma) are considered for the three scenarios. We provide benchmark
points with the MSSM spectrum, making the models suitable for a detailed
phenomenological analysis.Comment: 29 pages, 12 figures, reference adde
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5.
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V4Z 5H5, Canada.
Abstract
ABCA1, a cholesterol transporter expressed in the brain, has been shown recently to be required to maintain normal apoE levels and lipidation in the central nervous system. In addition, ABCA1 has been reported to modulate beta-amyloid (Abeta) production in vitro. These observations raise the possibility that ABCA1 may play a role in the pathogenesis of Alzheimer disease. Here we report that the deficiency of ABCA1 does not affect soluble or guanidine-extractable Abeta levels in Tg-SwDI/B or amyloid precursor protein/presenilin 1 (APP/PS1) mice, but rather is associated with a dramatic reduction in soluble apoE levels in brain. Although this reduction in apoE was expected to reduce the amyloid burden in vivo, we observed that the parenchymal and vascular amyloid load was increased in Tg-SwDI/B animals and was not diminished in APP/PS1 mice. Furthermore, we observed an increase in the proportion of apoE retained in the insoluble fraction, particularly in the APP/PS1 model. These data suggested that ABCA1-mediated effects on apoE levels and lipidation influenced amyloidogenesis in vivo.
PMID: 16207707 [PubMed - indexed for MEDLINE
An Inflationary Model in String Theory
We construct a model of inflation in string theory after carefully taking
into account moduli stabilization. The setting is a warped compactification of
Type IIB string theory in the presence of D3 and anti-D3-branes. The inflaton
is the position of a D3-brane in the internal space. By suitably adjusting
fluxes and the location of symmetrically placed anti-D3-branes, we show that at
a point of enhanced symmetry, the inflaton potential V can have a broad
maximum, satisfying the condition V''/V << 1 in Planck units. On starting close
to the top of this potential the slow-roll conditions can be met. Observational
constraints impose significant restrictions. As a first pass we show that these
can be satisfied and determine the important scales in the compactification to
within an order of magnitude. One robust feature is that the scale of inflation
is low, H = O(10^{10}) GeV. Removing the observational constraints makes it
much easier to construct a slow-roll inflationary model. Generalizations and
consequences including the possibility of eternal inflation are also discussed.
A more careful study, including explicit constructions of the model in string
theory, is left for the future.Comment: 27 pages, LaTeX, 1 eps figure. v2: references adde
The Strong Energy Condition and the S-Brane Singularity Problem
Recently it has been argued that, because tachyonic matter satisfies the
Strong Energy Condition [SEC], there is little hope of avoiding the
singularities which plague S-Brane spacetimes. Meanwhile, however, Townsend and
Wohlfarth have suggested an ingenious way of circumventing the SEC in such
situations, and other suggestions for actually violating it in the S-Brane
context have recently been proposed. Of course, the natural context for
discussions of [effective or actual] violations of the SEC is the theory of
asymptotically deSitter spacetimes, which tend to be less singular than
ordinary FRW spacetimes. However, while violating or circumventing the SEC is
necessary if singularities are to be avoided, it is not at all clear that it is
sufficient. That is, we can ask: would an asymptotically deSitter S-brane
spacetime be non-singular? We show that this is difficult to achieve; this
result is in the spirit of the recently proved "S-brane singularity theorem".
Essentially our results suggest that circumventing or violating the SEC may not
suffice to solve the S-Brane singularity problem, though we do propose two ways
of avoiding this conclusion.Comment: 13 pages, minor corrections and improvements, references adde
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