Intrusive Images in Psychological Disorders: Characteristics, Neural Mechanisms, and Treatment Implications

Involuntary images and visual memories are prominent in many types of psychopathology. Patients with posttraumatic stress disorder, other anxiety disorders, depression, eating disorders, and psychosis frequently report repeated visual intrusions corresponding to a small number of real or imaginary events, usually extremely vivid, detailed, and with highly distressing content. Both memory and imagery appear to rely on common networks involving medial prefrontal regions, posterior regions in the medial and lateral parietal cortices, the lateral temporal cortex, and the medial temporal lobe. Evidence from cognitive psychology and neuroscience implies distinct neural bases to abstract, flexible, contextualized representations (C-reps) and to inflexible, sensory-bound representations (S-reps). We revise our previous dual representation theory of posttraumatic stress disorder to place it within a neural systems model of healthy memory and imagery. The revised model is used to explain how the different types of distressing visual intrusions associated with clinical disorders arise, in terms of the need for correct interaction between the neural systems supporting S-reps and C-reps via visuospatial working memory. Finally, we discuss the treatment implications of the new model and relate it to existing forms of psychological therapy

Brane Induced Gravity: Codimension-2

We review the results of arXiv:hep-th/0703190, on brane induced gravity (BIG) in 6D. Among a large diversity of regulated codimension-2 branes, we find that for near-critical tensions branes live inside very deep throats which efficiently compactify the angular dimension. In there, 4D gravity first changes to 5D, and only later to 6D. The crossover from 4D to 5D is independent of the tension, but the crossover from 5D to 6D is not. This shows how the vacuum energy problem manifests in BIG: instead of tuning vacuum energy to adjust the 4D curvature, generically one must tune it to get the desired crossover scales and the hierarchy between the scales governing the 4D \to 5D \to 6D transitions. In the near-critical limit, linearized perturbation theory remains under control below the crossover scale, and we find that linearized gravity around the vacuum looks like a scalar-tensor theory.Comment: 16 pages latex, 2 .eps figs, based on the talks given at the "Sowers Workshop", Virginia Tech, May 14-18, 2007, "Cosmology and Strings" workshop at ICTP, Trieste, Italy, July 9-13, 2007, "Dark Energy In the Universe", Hakone, Japan, Sep 1-4, 2007 and "Zagreb Workshop 2007", Zagreb, Croatia, Nov 9-11, 2007; v2: added reference

A new framework of spatial targeting for single-species conservation planning

Context: Organisations acting to conserve and protect species across large spatial scales prioritise to optimise use of resources. Spatial conservation prioritization tools typically focus on identifying areas containing species groups of interest, with few tools used to identify the best areas for single-species conservation, in particular, to conserve currently widespread but declining species. / Objective: A single-species prioritization framework, based on temporal and spatial patterns of occupancy and abundance, was developed to spatially prioritize conservation action for widespread species by identifying smaller areas to work within to achieve predefined conservation objectives. / Methods: We demonstrate our approach for 29 widespread bird species in the UK, using breeding bird atlas data from two periods to define distribution, relative abundance and change in relative abundance. We selected occupied 10-km squares with abundance trends that matched species conservation objectives relating to maintaining or increasing population size or range, and then identified spatial clusters of squares for each objective using a Getis-Ord-Gi* or near neighbour analysis. / Results: For each species, the framework identified clusters of 20-km squares that enabled us to identify small areas in which species recovery action could be prioritized. / Conclusions: Our approach identified a proportion of species’ ranges to prioritize for species recovery. This approach is a relatively quick process that can be used to inform single-species conservation for any taxa if sufficiently fine-scale occupancy and abundance information is available for two or more time periods. This is a relatively simple first step for planning single-species focussed conservation to help optimise resource use

General Axisymmetric Solutions and Self-Tuning in 6D Chiral Gauged Supergravity

We re-examine the properties of the axially-symmetric solutions to chiral gauged 6D supergravity, recently found in refs. hep-th/0307238 and hep-th/0308064. Ref. hep-th/0307238 finds the most general solutions having two singularities which are maximally-symmetric in the large 4 dimensions and which are axially-symmetric in the internal dimensions. We show that not all of these solutions have purely conical singularities at the brane positions, and that not all singularities can be interpreted as being the bulk geometry sourced by neutral 3-branes. The subset of solutions for which the metric singularities are conical precisely agree with the solutions of ref. hep-th/0308064. Establishing this connection between the solutions of these two references resolves a minor conflict concerning whether or not the tensions of the resulting branes must be negative. The tensions can be both negative and positive depending on the choice of parameters. We discuss the physical interpretation of the non-conical solutions, including their significance for the proposal for using 6-dimensional self-tuning to understand the small size of the observed vacuum energy. In passing we briefly comment on a recent paper by Garriga and Porrati which criticizes the realization of self-tuning in 6D supergravity.Comment: 27 pages, 1 figure; JHEP3 style; Some references added, and discussion of tension constraints and unwarped solutions made more explici

Zero modes of six-dimensional Abelian vortices

We analyze the fluctuations of Nielsen-Olesen vortices arising in the six-dimensional Abelian-Higgs model. The regular geometry generated by the defect breaks spontaneously six-dimensional Poincar\'e symmetry leading to a warped space-time with finite four-dimensional Planck mass. As a consequence, the zero mode of the spin two fluctuations of the geometry is always localized but the graviphoton fields, corresponding to spin one metric fluctuations, give rise to zero modes which are not localized either because of their behaviour at infinity or because of their behaviour near the core of the vortex. A similar situation occurs for spin zero fluctuations. Gauge field fluctuations exhibit a localized zero mode.Comment: 45 pages in Revtex style with 4 figure

On Bouncing Brane-Worlds, S-branes and Branonium Cosmology

We present several higher-dimensional spacetimes for which observers living on 3-branes experience an induced metric which bounces. The classes of examples include boundary branes on generalised S-brane backgrounds and probe branes in D-brane/anti D-brane systems. The bounces we consider normally would be expected to require an energy density which violates the weak energy condition, and for our co-dimension one examples this is attributable to bulk curvature terms in the effective Friedmann equation. We examine the features of the acceleration which provides the bounce, including in some cases the existence of positive acceleration without event horizons, and we give a geometrical interpretation for it. We discuss the stability of the solutions from the point of view of both the brane and the bulk. Some of our examples appear to be stable from the bulk point of view, suggesting the possible existence of stable bouncing cosmologies within the brane-world framework.Comment: 35 pages, 7 figures, JHEP style. Title changed and references adde

A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial

Background While combination antiretroviral therapy has extended the life expectancy of those infected with human immunodeficiency virus (HIV), there is a high prevalence of comorbidities that increase the risk of cardiovascular morbidity and mortality among people living with HIV/AIDS (PLWHA). The side effects associated with antiretroviral therapy (ART) lead to multiple metabolic disorders, making the management of these metabolic issues and risk of cardiovascular disease (CVD) in those treated with ART a critical issue. Clinical research trials, primarily clinical exercise, rarely include this population due to unique challenges in research methods with underserved minority populations living with a life threatening illness like HIV/AIDS. This paper describes the rationale and design of a randomized clinical trial evaluating the feasibility of a home-based exercise program designed to increase physical activity (PA) and reduce the risk of CVD in PLWHA. Methods/design PLWHA being treated with ART will be randomly assigned to one of two groups: a home-based PA intervention or standard care. All participants will receive an educational weight loss workbook and pedometer for self-monitoring of PA. Only those in the intervention group will receive additional elastic Thera-bands® for strength training and behavioral telephone based coaching. Discussion This study will evaluate the feasibility of a home-based program designed to increase PA among PLWHA. Further, it will evaluate the effectiveness of such a program to decrease modifiable risk factors for CVD as a secondary outcome. This study was funded by the NIH/NINR R21 Grant 1R21NRO11281

Galileon Hairs of Dyson Spheres, Vainshtein's Coiffure and Hirsute Bubbles

We study the fields of spherically symmetric thin shell sources, a.k.a. Dyson spheres, in a {\it fully nonlinear covariant} theory of gravity with the simplest galileon field. We integrate exactly all the field equations once, reducing them to first order nonlinear equations. For the simplest galileon, static solutions come on {\it six} distinct branches. On one, a Dyson sphere surrounds itself with a galileon hair, which far away looks like a hair of any Brans-Dicke field. The hair changes below the Vainshtein scale, where the extra galileon terms dominate the minimal gradients of the field. Their hair looks more like a fuzz, because the galileon terms are suppressed by the derivative of the volume determinant. It shuts off the `hair bunching' over the `angular' 2-sphere. Hence the fuzz remains dilute even close to the source. This is really why the Vainshtein's suppression of the modifications of gravity works close to the source. On the other five branches, the static solutions are all {\it singular} far from the source, and shuttered off from asymptotic infinity. One of them, however, is really the self-accelerating branch, and the singularity is removed by turning on time dependence. We give examples of regulated solutions, where the Dyson sphere explodes outward, and its self-accelerating side is nonsingular. These constructions may open channels for nonperturbative transitions between branches, which need to be addressed further to determine phenomenological viability of multi-branch gravities.Comment: 29+1 pages, LaTeX, 2 .pdf figure

Conservation equation on braneworlds in six dimensions

We study braneworlds in six-dimensional Einstein-Gauss-Bonnet gravity. The Gauss-Bonnet term is crucial for the equations to be well-posed in six dimensions when non-trivial matter on the brane is included (the also involved induced gravity term is not significant for their structure), and the matching conditions of the braneworld are known. We show that the energy-momentum of the brane is always conserved, independently of any regular bulk energy-momentum tensor, contrary to the situation of the five-dimensional case.Comment: References added, minor changes, 3 pages, RevTeX, to app. in Class. Quant. Gra