6 research outputs found
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UMass Amherst Energy Modeling Guidelines
Facilities & Campus Services, Sustainable UMass and Campus Planning support sustainability and energy conservation initiatives by providing in-house resources to campus staff as well as designers and contractors working with the University. The Campus energy Modeling Guidelines were developed in 2015 as a resource on how to: i) generate energy models for campus buildings; ii) provide quality assurance review of current energy models; and iii) share UMass Amherst energy modeling input parameters with project design teams for them to establish a baseline building energy profile
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UMass Amherst Building Measurement, Verification, Coordination and Template Plan
Facilities & Campus Services, Sustainable UMass and Campus Planning support sustainability and energy conservation initiatives by providing in-house resources to campus staff as well as designers and contractors working with the University. The UMass Amherst Building Measurement, Verification, Coordination and Template Plan was begun in 2013 and finalized in 2015 as a resource to project teams that undertake the measurement and verification of building systems during the first year of occupancy of a new building and renovation project, particularly projects undergoing LEED certification
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UMass Amherst Campus Master Plan Sustainability Chapter
The UMass Amherst Campus Master Plan Sustainability Chapter articulates the manner in which the Campus Master Plan 2012 principles translate into specific recommendations for campus systems development in support of future smart growth. It summarizes the current physical campus-scale planning projects that Facilities & Campus Services have completed during and after the Master Plan process, and incorporates other operational and educational initiatives that have engaged our campus community as we plan for sustainability.
The CMP Chapter is organized in three major sections: i) sustainability overview; ii) campus master plan systems; iii) current initiatives; and iv) next steps. The first section provides the context for sustainability planning at UMass Amherst and summarizes key drivers, such as the Climate Action Plan of 2012 and our approach to greenhouse gas emissions accounting. The second section articulates the Campus Master Plan 2012 systems approach to sustainability and reviews other completed operational initiatives in infrastructure and facilities planning. The overview of current initiatives describes major efforts to advance sustainability across the campus community and is the basis for outlining the steps that Facilities & Campus Services and Sustainable UMass plan to take to advance the goal for a carbon neutral campus
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 complementary screens to identify FDA-approved drugs and drug-like small molecules with activity against T-ALL. We developed a zebrafish system to screen small molecules for toxic activity toward MYC-overexpressing thymocytes and used a human T-ALL cell line to screen for small molecules that synergize with Notch inhibitors. We identified the antipsychotic drug perphenazine in both screens due to its ability to induce apoptosis in fish, mouse, and human T-ALL cells. Using ligand-affinity chromatography coupled with mass spectrometry, we identified protein phosphatase 2A (PP2A) as a perphenazine target. T-ALL cell lines treated with perphenazine exhibited rapid dephosphorylation of multiple PP2A substrates and subsequent apoptosis. Moreover, shRNA knockdown of specific PP2A subunits attenuated perphenazine activity, indicating that PP2A mediates the drug's antileukemic activity. Finally, human T-ALLs treated with perphenazine exhibited suppressed cell growth and dephosphorylation of PP2A targets in vitro and in vivo. Our findings provide a mechanistic explanation for the recurring identification of phenothiazines as a class of drugs with anticancer effects. Furthermore, these data suggest that pharmacologic PP2A activation in T-ALL and other cancers driven by hyperphosphorylated PP2A substrates has therapeutic potential
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Common Data Element Collection in Underserved School Communities: Challenges and Recommendations
OBJECTIVESTo provide recommendations for future common data element (CDE) development and collection that increases community partnership, harmonizes data interpretation, and continues to reduce barriers of mistrust between researchers and underserved communities. METHODSWe conducted a cross-sectional qualitative and quantitative evaluation of mandatory CDE collection among Rapid Acceleration of Diagnostics-Underserved Populations Return to School project teams with various priority populations and geographic locations in the United States to: (1) compare racial and ethnic representativeness of participants completing CDE questions relative to participants enrolled in project-level testing initiatives and (2) identify the amount of missing CDE data by CDE domain. Additionally, we conducted analyses stratified by aim-level variables characterizing CDE collection strategies. RESULTSThere were 15 study aims reported across the 13 participating Return to School projects, of which 7 (47%) were structured so that CDEs were fully uncoupled from the testing initiative, 4 (27%) were fully coupled, and 4 (27%) were partially coupled. In 9 (60%) study aims, participant incentives were provided in the form of monetary compensation. Most project teams modified CDE questions (8/13; 62%) to fit their population. Across all 13 projects, there was minimal variation in the racial and ethnic distribution of CDE survey participants from those who participated in testing; however, fully uncoupling CDE questions from testing increased the proportion of Black and Hispanic individuals participating in both initiatives. CONCLUSIONSCollaboration with underrepresented populations from the early study design process may improve interest and participation in CDE collection efforts