Hall viscosity, orbital spin, and geometry: paired superfluids and quantum Hall systems

The Hall viscosity, a non-dissipative transport coefficient analogous to Hall conductivity, is considered for quantum fluids in gapped or topological phases. The relation to mean orbital spin per particle discovered in previous work by one of us is elucidated with the help of examples, using the geometry of shear transformations and rotations. For non-interacting particles in a magnetic field, there are several ways to derive the result (even at non-zero temperature), including standard linear response theory. Arguments for the quantization, and the robustness of Hall viscosity to small changes in the Hamiltonian that preserve rotational invariance, are given. Numerical calculations of adiabatic transport are performed to check the predictions for quantum Hall systems, with excellent agreement for trial states. The coefficient of k^4 in the static structure factor is also considered, and shown to be exactly related to the orbital spin and robust to perturbations in rotation invariant systems also.Comment: v2: Now 30 pages, 10 figures; new calculation using disk geometry; some other improvements; no change in result

Schur Polynomials and the Yang-Baxter equation

We show that within the six-vertex model there is a parametrized Yang-Baxter equation with nonabelian parameter group GL(2)xGL(1) at the center of the disordered regime. As an application we rederive deformations of the Weyl character formule of Tokuyama and of Hamel and King.Comment: Revised introduction; slightly changed reference

Correlation Functions of Harish-Chandra Integrals over the Orthogonal and the Symplectic Groups

The Harish-Chandra correlation functions, i.e. integrals over compact groups of invariant monomials prod tr{X^{p_1} Omega Y^{q_1} Omega^dagger X^{p_2} ... with the weight exp tr{X Omega Y Omega^dagger} are computed for the orthogonal and symplectic groups. We proceed in two steps. First, the integral over the compact group is recast into a Gaussian integral over strictly upper triangular complex matrices (with some additional symmetries), supplemented by a summation over the Weyl group. This result follows from the study of loop equations in an associated two-matrix integral and may be viewed as the adequate version of Duistermaat-Heckman's theorem for our correlation function integrals. Secondly, the Gaussian integration over triangular matrices is carried out and leads to compact determinantal expressions.Comment: 58 pages; Acknowledgements added; small corrections in appendix A; minor changes & Note Adde

Generalized Involution Models for Wreath Products

We prove that if a finite group $H$ has a generalized involution model, as defined by Bump and Ginzburg, then the wreath product $H \wr S_n$ also has a generalized involution model. This extends the work of Baddeley concerning involution models for wreath products. As an application, we construct a Gelfand model for wreath products of the form $A \wr S_n$ with $A$ abelian, and give an alternate proof of a recent result due to Adin, Postnikov, and Roichman describing a particularly elegant Gelfand model for the wreath product \ZZ_r \wr S_n. We conclude by discussing some notable properties of this representation and its decomposition into irreducible constituents, proving a conjecture of Adin, Roichman, and Postnikov's.Comment: 29 page

Automorphic Instanton Partition Functions on Calabi-Yau Threefolds

We survey recent results on quantum corrections to the hypermultiplet moduli space M in type IIA/B string theory on a compact Calabi-Yau threefold X, or, equivalently, the vector multiplet moduli space in type IIB/A on X x S^1. Our main focus lies on the problem of resumming the infinite series of D-brane and NS5-brane instantons, using the mathematical machinery of automorphic forms. We review the proposal that whenever the low-energy theory in D=3 exhibits an arithmetic "U-duality" symmetry G(Z) the total instanton partition function arises from a certain unitary automorphic representation of G, whose Fourier coefficients reproduce the BPS-degeneracies. For D=4, N=2 theories on R^3 x S^1 we argue that the relevant automorphic representation falls in the quaternionic discrete series of G, and that the partition function can be realized as a holomorphic section on the twistor space Z over M. We also offer some comments on the close relation with N=2 wall crossing formulae.Comment: 25 pages, contribution to the proceedings of the workshop "Algebra, Geometry and Mathematical Physics", Tjarno, Sweden, 25-30 October, 201

Loop Quantum Gravity a la Aharonov-Bohm

The state space of Loop Quantum Gravity admits a decomposition into orthogonal subspaces associated to diffeomorphism equivalence classes of spin-network graphs. In this paper I investigate the possibility of obtaining this state space from the quantization of a topological field theory with many degrees of freedom. The starting point is a 3-manifold with a network of defect-lines. A locally-flat connection on this manifold can have non-trivial holonomy around non-contractible loops. This is in fact the mathematical origin of the Aharonov-Bohm effect. I quantize this theory using standard field theoretical methods. The functional integral defining the scalar product is shown to reduce to a finite dimensional integral over moduli space. A non-trivial measure given by the Faddeev-Popov determinant is derived. I argue that the scalar product obtained coincides with the one used in Loop Quantum Gravity. I provide an explicit derivation in the case of a single defect-line, corresponding to a single loop in Loop Quantum Gravity. Moreover, I discuss the relation with spin-networks as used in the context of spin foam models.Comment: 19 pages, 1 figure; v2: corrected typos, section 4 expanded

Structural Variants Drive Context-Dependent Oncogene Activation in Cancer

Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer-promoter rewiring and human disease, particularly in the context of cancer3. However, only a small minority of SVs are associated with altered gene expression4,5, and it remains unclear why certain SVs lead to changes in distal gene expression and others do not. To address these questions, we used a combination of genomic profiling and genome engineering to identify sites of recurrent changes in 3D genome structure in cancer and determine the effects of specific rearrangements on oncogene activation. By analysing Hi-C data from 92 cancer cell lines and patient samples, we identified loci affected by recurrent alterations to 3D genome structure, including oncogenes such as MYC, TERT and CCND1. By using CRISPR-Cas9 genome engineering to generate de novo SVs, we show that oncogene activity can be predicted by using \u27activity-by-contact\u27 models that consider partner region chromatin contacts and enhancer activity. However, activity-by-contact models are only predictive of specific subsets of genes in the genome, suggesting that different classes of genes engage in distinct modes of regulation by distal regulatory elements. These results indicate that SVs that alter 3D genome organization are widespread in cancer genomes and begin to illustrate predictive rules for the consequences of SVs on oncogene activation

Pelvic organ prolapse symptoms in relation to POPQ, ordinal stages and ultrasound prolapse assessment

Adequate staging of pelvic organ prolapse is important in clinical practice and research. The ability of the POPQ, ordinal stages and ultrasound prolapse assessment were evaluated for their ability to discriminate between women with and without prolapse symptoms. The leading edge of the predominant compartment in the three assessment systems was used for the calculation of receiver operating characteristics curves. Two hundred and sixty five (265) consecutive women were evaluated. The area under the receiver operating characteristics curve for the three staging systems ranged from 0.715 to 0.783. POPQ staging and ordinal staging performed equally well in the prediction of prolapse symptoms (p = 0.780), and both performed better as compared with ultrasound prolapse assessment (p = 0.048 and p = 0.015, respectively). Prolapse staging can equally be performed by the POPQ and ordinal stages systems as far as the discrimination between women with and without prolapse symptoms is concerned. The ultrasound prolapse assessment does not perform better as compared with these two systems