Soluble interleukin-1 receptor type 2 plasma levels in Parkinson’s disease: relationship with cardiac autonomic profile before and after peripheral mechanical somatosensory stimulation

Introduction: Systemic inflammation promotes neurodegeneration in Parkinson’s disease (PD). Interleukin-1 receptor type 2 (sIL-1R2) plasma levels increase during inflammation. Data on sIL-1R2 in PD patients and its relationship with PD cardiac autonomic profile are limited, given the possible anti-inflammatory effect of vagal activation. Previously, automated mechanical peripheral somatosensory stimulation (AMPSS) enhanced cardiac vagal modulation. Objectives were to 1) evaluate sIL-1R2 plasma concentrations in PD patients and healthy controls and 2) investigate the correlations between sIL-1R2 and cardiac autonomic indices obtained by spectrum analysis of heart rate variability before and after AMPSS.Methods: sIL-1R2 plasma levels were assessed in 48 PD patients and 50 healthy controls. Electrocardiogram and beat-by-beat arterial pressure were recorded at baseline and after 5 AMPSS sessions in 16 PD patients.Results: PD patients had higher sIL-1R2 levels than controls. In the PD subgroup, an inverse correlation between sIL-1R2 and HFnu was found. There was a negative correlation between changes induced by AMPSS on HFnu and sIL-1R2.Discussion: Higher sIL-1R2 levels in PD patients reflect the inflammatory dysregulation associated with the disease. In PD patients, higher sIL-1R2 was associated with reduced cardiovagal tone. Increased cardiovagal modulation following AMPSS was associated with lower sIL-1R2 levels in Parkinson’s disease patients, suggesting inflammatory state improvement

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Update on 67Cu half-life

The half-life of 67Cu was newly determined by measurement of its 185 keV γ-ray (48.7 %) over the period of 13 days (approx. 5 × T½). 67Cu was prepared by deuteron irradiation of enriched 70Zn targets. The 67Cu half-life value which resulted from five independent measurements is estimated to be 61.81 (22) h.JRC.I.5-Nanobioscience

Preparation of 67Cu via deuteron irradiation of 70Zn

A method for preparation of n.c.a. 67Cu based on deuteron irradiation of enriched 70Zn is presented. Cross-sections for 67Cu formation were determined by the stacked foil technique for deuteron energies in the range from 10 to 20 MeV for the first time. Irradiations of 70Zn foils were followed by radiochemical separation of 67Cu from the target material and co-produced radionuclidic impurities. The maximum cross-section value of 25.5 ± 2.2 mb was reached at 19 MeV. The integral yield in the energy window of 20 → 10 MeV on 95 % enriched 70Zn is estimated at 4.2 MBq/μAh (110 μCi/μAh) or 375 MBq/μA (10 mCi/μA) at saturation.JRC.I.4-Nanobioscience

Measurement of the natHf(d,x)177Ta cross section and impact of erroneous gamma-ray intensities

In this work, excitation functions for deuteron-induced reactions on natural hafnium have been measured in the energy range 7 - 17 MeV, using the stacked-foil technique. Particular attention has been paid to the reaction natHf(d,y)177Ta, because measured values have been found to be in disagreement with previously published data. This discrepancy is due to an error in the 2003 ENSDF absolute gamma-ray intensities of 177Hf following the decay of 177Ta, which are about a factor of 3 higher compared to other published data. As a consequence, the cross section values for the natHf(d,x)177Ta reaction reported in a peer reviewed paper and included in the EXFOR database are wrong. The same wrong gamma-ray intensities may have been used in other papers reporting on natHf(p,x)177Ta and natW(p,x)177Ta cross sections.JRC.D.4-Nuclear physic

Single shot laser ablation MC-ICP-MS for depth profile analysis of U isotopes in UO2 single crystals

An analytical procedure for the determination of the n(235U)/n(238U) ratio in consecutive layers of UO2 single crystals was developed and validated. A circular 25 µm laser beam and a fluence of only 0.2 J cm-2 were employed for depth profiling of UO2 single crystals with U isotopes being detected via MC-ICP-MS. The time-resolved 235U and 238U MC-ICP-MS signals obtained from individual laser shots were evaluated automatically with a home-made software. Downhole fractionation of the n(235U)/n(238U) ratio was excluded by shooting 80 laser pulses on a reference UO2 single crystal of known composition (N=5), revealing no measurable change in its U isotopic ratio during depth profiling. A linear relationship between the number of laser shots and the average depth of the generated laser ablation craters was established employing confocal laser scanning profilometry. After ~50 laser shots this relationship flattened and surface roughness of the crater bottoms increased noticeably at the same time. The employed ns-laser ablation system produced conical craters with their corresponding crater diameters expanding with increasing number of laser pulses. Using a dual beam focused ion beam (FIB), high resolution scanning electron microscopy (SEM) micrographs revealed the formation of rectangular "tiles" on the reference UO2 single crystal already after five laser shots. The ordered, rectangular structure was disappearing progressively with increasing number of laser pulses, while simultaneously the sub-micrometric porosity amplified, leading to a sombrero-like crater profile. The depth profiling capabilities of the laser ablation system were applied to two UO2 single crystals produced under different experimental conditions. Both featured a n(235U)/n(238U) ratio gradient, containing enriched U at the surface and depleted U in the bulk. As such, the variable diffusion behaviour of 235U into the UO2 single crystals was studied systematically. The laser ablation rate varied distinctly between the two UO2 single crystals, i.e. ~7.5 nm and ~13 nm, requiring individual depth calibration for each material.JRC.G.II.6-Nuclear Safeguards and Forensic