Results of the Study for the Antihypertensive Effect in the Panzeria Alaschanica Kupr Plant

Objectives: To study the effect of the plant Panzeria alaschanica Kupr on lowering blood pressure. Methods: The experiment was performed using Sharon Leng Hong Ong (2009) using a male rat weighing 150 - 250 grams. On days 5, 8, 13, and 15 of the experiment, ECG, heart rate, and arterial pressure were measured in the rat’s tail with a Neurobotic systole 1.2 instruments. At the end of the experiment, the content of renin, angiotensin II and aldosterone were determined by enzyme-linked immunosorbent assay. Results: According to the results of the study, the experimental group of plant Panzeria alaschanica Kupr ingested a dose of 160 mg/kg of renin 36.8 % compared with the control group that caused the pathological model, the amount of aldosterone in animals plant Panzeria alaschanica Kupr who ingested a dose of 32 mg/kg were 43.5 % of the ingested animals compared with the pathogenic group, the amount of angiotensin II in the plant Panzeria alaschanica Kupr was 64 mg/kg animals that ingested in, was reduced by a statistically significant difference (p < 0.05) of 34.3 % compared with the control group generated by the pathological model. Conclusion: Panzeria alaschanica Kupr has a 36.8 % reduced blood pressure by affecting the renin, angiotensin, and aldosterone systems

The Effect of Panzeria Alaschanica Kupr. on Carrageenan-Induced Acute Inflammation in Rats

Objectives: In the present study, we aimed to investigate the effect of Panzeria alaschanica Kupr. (P. alaschanica) on carrageenan-induced acute inflammation in rats. Method: Carrageenan-induced rat paw edema was used to evaluate the anti-inflammatory activity. P. alaschanica extract (32, 64, and 160 mg/kg/ BW) or vehicle was given orally 60 minutes before the subplantar injection of carrageenan. Ibuprofen (100 mg/kg) was used as a standard drug. The carrageenan-injected paw was measured 30, 60, 120, 180, and 240 minutes after the carrageenan injection. The levels of serum tumor necrosis factor (TNF)-α, interleukin (IL)-ELISA measured 1β, and IL-6. Results: The P. alaschanica at all given doses significantly (p˂0.01) inhibited carrageenan-induced rat paw edema. Moreover, it significantly reduced TNF-α, IL-1β, and IL-6 serum levels at different doses (p˂0.01). The anti-inflammatory effect of P. alaschanica was comparable to ibuprofen. Conclusion: P. alaschanica has an anti-inflammatory impact on carrageenan-induced paw edema in rats. The mechanism of action may partly be via reducing the levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6