86 research outputs found
Compensation of gain saturation in SOA-gates by interferometric Mach-Zehnder wavelength converters
Improvement of input power dynamic range for 20 Gbit/s optical WDM switch nodes using an integrated Michelson wavelength converter
Impact on traffic and transmission performance of all-optical wavelength converters placed at the network interface or in OXCNs
All-optical wavelength conversion at bit rates above 10 Gb/s using semiconductor optical amplifiers
Self-management of musculoskeletal hand pain and hand problems in community-dwelling adults aged 50 years and older: results from a cross-sectional study in a UK population
Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management
Osteoarthritis (OA) is a highly prevalent condition and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations, and frustration in undertaking everyday activities. The condition presents clinically with changes to the bone, ligaments, cartilage and synovial tissue, which can be observed using radiography, ultrasonography or MRI. Hand OA is a heterogeneous disorder and is considered to be multifactorial in aetiology. This review provides an overview of the epidemiology, presentation and burden of hand OA, including an update on hand OA imaging (including the development of novel techniques), disease mechanisms and management. In particular, areas for which new evidence has substantially changed the way we understand, consider and treat hand OA are highlighted. For example, genetic studies, clinical trials and careful prospective imaging studies from the past 5 years are beginning to provide insights into the pathogenesis of hand OA that might uncover new therapeutic targets in disease
Elimination of low steady-state concentrations of [5,6-H]prostaglandin E in the pulmonary and the systemic circulations of anaesthetized rats
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