Neutrino Emission from the Direction of the Blazar TXS 0506+056 Prior to the IceCube-170922A Alert

A high-energy neutrino event detected by IceCube on 22 September 2017 was coincident in direction and time with a gamma-ray flare from the blazar TXS 0506+056. Prompted by this association, we investigated 9.5 years of IceCube neutrino observations to search for excess emission at the position of the blazar. We found an excess of high-energy neutrino events, with respect to atmospheric backgrounds, at that position between September 2014 and March 2015. Allowing for time-variable flux, this constitutes 3.5σ evidence for neutrino emission from the direction of TXS 0506+056, independent of and prior to the 2017 flaring episode. This suggests that blazars are identifiable sources of the high-energy astrophysical neutrino flux

Uses of phage display in agriculture: Sequence analysis and comparative modeling of late embryogenesis abundant client proteins suggest protein-nucleic acid binding functionality

A group of intrinsically disordered, hydrophilic proteins-Late Embryogenesis Abundant (LEA) proteins-has been linked to survival in plants and animals in periods of stress, putatively through safeguarding enzymatic function and prevention of aggregation in times of dehydration/heat. Yet despite decades of effort, the molecular-level mechanisms defining this protective function remain unknown. A recent effort to understand LEA functionality began with the unique application of phage display, wherein phage display and biopanning over recombinant Seed Maturation Protein homologs from Arabidopsis thaliana and Glycine max were used to retrieve client proteins at two different temperatures, with one intended to represent heat stress. From this previous study, we identified 21 client proteins for which clones were recovered, sometimes repeatedly. Here, we use sequence analysis and homology modeling of the client proteins to ascertain common sequence and structural properties that may contribute to binding affinity with the protective LEA protein. Our methods uncover what appears to be a predilection for protein-nucleic acid interactions among LEA client proteins, which is suggestive of subcellular residence. The results from this initial computational study will guide future efforts to uncover the protein protective mechanisms during heat stress, potentially leading to phage-display-directed evolution of synthetic LEA molecules

Revisiting the implications of Liouville's theorem to the anisotropy of cosmic rays

We present a solution to Liouville's equation for an ensemble of charged particles propagating in magnetic fields. The solution is presented using an expansion in spherical harmonics of the phase space density, allowing a direct interpretation of the distribution of arrival directions of cosmic rays. The results are found for chosen conditions of variability and source distributions. We show there are two conditions for an initially isotropic flux of particles to remain isotropic while traveling through a magnetic field: isotropy and homogeneity of the sources. The formalism is used to analyze the data measured by the Pierre Auger Observatory, contributing to the understanding of the dependence of the dipole amplitude with energy and predicting the energy in which the quadrupole signal should be measured

Observation of a large-scale anisotropy in the arrival directions of cosmic rays above 8 × 10 18 eV

Cosmic rays are atomic nuclei arriving from outer space that reach the highest energies observed in nature. Clues to their origin come from studying the distribution of their arrival directions. Using 3 × 10 4 cosmic rays with energies above 8 × 10 18 electron volts, recorded with the Pierre Auger Observatory from a total exposure of 76,800 km2 sr year, we determined the existence of anisotropy in arrival directions. The anisotropy, detected at more than a 5.2σ level of significance, can be described by a dipole with an amplitude of 6.5 +1.3 -0.9 percent toward right ascension αd = 100 ± 10 degrees and declination δd = -24 +12 -13 degrees. That direction indicates an extragalactic origin for these ultrahighenergy particles.La nómina completa de autores puede verse en el archivo asociado a este ítem.Facultad de Ciencias Exacta

Observation of a large-scale anisotropy in the arrival directions of cosmic rays above 8 × 10 18 eV

Cosmic rays are atomic nuclei arriving from outer space that reach the highest energies observed in nature. Clues to their origin come from studying the distribution of their arrival directions. Using 3 × 10 4 cosmic rays with energies above 8 × 10 18 electron volts, recorded with the Pierre Auger Observatory from a total exposure of 76,800 km2 sr year, we determined the existence of anisotropy in arrival directions. The anisotropy, detected at more than a 5.2σ level of significance, can be described by a dipole with an amplitude of 6.5 +1.3 -0.9 percent toward right ascension αd = 100 ± 10 degrees and declination δd = -24 +12 -13 degrees. That direction indicates an extragalactic origin for these ultrahighenergy particles.La nómina completa de autores puede verse en el archivo asociado a este ítem.Facultad de Ciencias Exacta