Contractions, Hopf algebra extensions and cov. differential calculus

We re-examine all the contractions related with the ${\cal U}_q(su(2))$ deformed algebra and study the consequences that the contraction process has for their structure. We also show using ${\cal U}_q(su(2))\times{\cal U}(u(1))$ as an example that, as in the undeformed case, the contraction may generate Hopf algebra cohomology. We shall show that most of the different Hopf algebra deformations obtained have a bicrossproduct or a cocycle bicrossproduct structure, for which we shall also give their dual `group' versions. The bicovariant differential calculi on the deformed spaces associated with the contracted algebras and the requirements for their existence are examined as well.Comment: TeX file, 25 pages. Macros are include

On the coupling of vector fields to the Gauss-Bonnet invariant

Inflationary models including vector fields have attracted a great deal of attention over the past decade. Such an interest owes to the fact that they might contribute to, or even be fully responsible for, the curvature perturbation imprinted in the CMB. However, the necessary breaking of the vector field's conformal invariance during inflation is not without problems. In recent years it has been realized that a number of instabilities endangering the consistency of the theory arise when the conformal invariance is broken by means of a non-minimal coupling to gravity. In this paper we consider a massive vector field non-minimally coupled to gravity through the Gauss-Bonnet invariant, and investigate whether the vector can obtain a nearly scale-invariant perturbation spectrum while evading the emergence of perturbative instabilities. We find that the strength of the coupling must be extremely small if the vector field is to have a chance to contribute to the total curvature perturbation.Comment: 8 pages, 1 figur

Effective actions, relative cohomology and Chern Simons forms

The explicit expression of all the WZW effective actions for a simple group G broken down to a subgroup H is established in a simple and direct way, and the formal similarity of these actions to the Chern-Simons forms is explained. Applications are also discussed.Comment: 11 pages. Latex2e file. Published versio

Na/K pump regulation of cardiac repolarization: Insights from a systems biology approach

The sodium-potassium pump is widely recognized as the principal mechanism for active ion transport across the cellular membrane of cardiac tissue, being responsible for the creation and maintenance of the transarcolemmal sodium and potassium gradients, crucial for cardiac cell electrophysiology. Importantly, sodium-potassium pump activity is impaired in a number of major diseased conditions, including ischemia and heart failure. However, its subtle ways of action on cardiac electrophysiology, both directly through its electrogenic nature and indirectly via the regulation of cell homeostasis, make it hard to predict the electrophysiological consequences of reduced sodium-potassium pump activity in cardiac repolarization. In this review, we discuss how recent studies adopting the Systems Biology approach, through the integration of experimental and modeling methodologies, have identified the sodium-potassium pump as one of the most\ud important ionic mechanisms in regulating key properties of cardiac repolarization and its rate-dependence, from subcellular to whole organ levels. These include the role of the pump in the biphasic modulation of cellular repolarization and refractoriness, the rate control of intracellular sodium and calcium dynamics and therefore of the adaptation of repolarization to changes in heart rate, as well as its importance in regulating pro-arrhythmic substrates through modulation of dispersion of repolarization and restitution. Theoretical findings are consistent across a variety of cell types and species including human, and widely in agreement with experimental findings. The novel insights and hypotheses on the role of the pump in cardiac electrophysiology obtained through this integrative approach could eventually lead to novel therapeutic and diagnostic strategies