57 research outputs found
Evaluation of developmental neurotoxicity: some important issues focused on neurobehavioral development
Exposure of the developing organism to industrial chemicals and physical factors represents a serious risk factor for the development of neurobehavioral disorders, such as attention-deficit hyperactivity disorder, autism and mental retardation. Appropriate animal models are needed to test potentially harmful effects and mechanisms of developmental neurotoxicity of various chemical substances. However, there are significant human vs. rat differences in the brain developmental profile which should be taken into account in neurotoxicity studies. Subtle behavioral alterations are hard to detect by traditional developmental toxicity and teratogenicity studies, and in many cases they remain hidden. They can however be revealed by using special behavioral, endocrine and/or pharmacological challenges, such as repeated behavioral testing, exposure to single stressful stimulus or drugs. Further, current neurobehavioral test protocols recommend to test animals up to their adulthood. However some behavioral alterations, such as anxiety-like behavior or mental deficiency, may become manifest in later periods of development. Our experimental and scientific experiences are highly suggestive for a complex approach in testing potential developmental neurotoxicity. Strong emphasis should be given on repeated behavioral testing of animals up to senescence and on using proper pharmacological and/or stressful challenges
Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats
Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
Generation of Nitrotyrosine Precedes Activation of Metalloproteinase in Myocardium of Hyperhomocysteinemic Rats
Validation of Peripheral Tissue Cholinesterase Activity Assessment in Rats Administered Chlorpyrifos by Gavage
Levosimendan Does Not Improve Cardiac Output or Blood Pressure in a Rodent Model of Propranolol Toxicity When Administered Using Various Dosing Regimens
Developmental Toxicity Studies in Rats and Rabbits with DOV 21,947: A Triple Reuptake Inhibitor
Anatomical and Functional Changes to the Colonic Neuromuscular Compartment after Experimental Spinal Cord Injury
Effects of Prenatal Ethanol Exposure on Juvenile Play-Fighting and Postpubertal Aggression in Rats
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