A benchmarking study of two trauma centres highlighting limitations when standardising mortality for comorbidity

<p>Abstract</p> <p>Introduction</p> <p>A continuous process of trauma centre evaluation is essential to ensure the development and progression of trauma care at regional, national and international levels. Evaluation may be by comparison between pooled datasets or by direct benchmarking between centres. This study attempts to benchmark mortality at two trauma centres standardising this for multiple case-mix factors, which includes the prevalence of individual background pre-existing diseases within the study population.</p> <p>Methods</p> <p>Trauma patients with an Injury Severity Score (ISS) >15 admitted to the two centres in 2001 and 2002 were included in the study with the exception of those who died in the emergency department. Patient characteristics were analysed in terms of 18 case-mix factors including Glasgow Coma Scale on arrival, Injury Severity Score and the presence or absence of 9 co-morbidity types, and patient outcome was compared based on in-hospital mortality before and after standardisation.</p> <p>Results</p> <p>Crude mortality was greater at UHNS (18.2 vs 14.5%) with a non-significant odds ratio of 1.31 prior to adjusting for case-mix (P = 0.171). Adjustment for case mix using logistic regression analysis altered the odds ratio to 1.64, which was not significant (P = 0.069).</p> <p>Discussion</p> <p>This study did not demonstrate any significant difference in the outcome of patients treated at either hospital during the study period. More importantly it has raised several important methodological issues pertinent to researchers undertaking registry based benchmarking studies. Data at the two registries was collected by personnel with differing backgrounds, in formats that were not completely compatible and was collected for patients that met different admissions criteria. The inclusion of a meaningful analysis of pre-existing disease was limited by the availability of robust data and sample size. We suggest greater communication between trauma research coordinators to ensure equivalent data collection and facilitate future benchmarking studies.</p

Porous silica nanosheets in PIM-1 membranes for CO2 separation

PIM-1-based freestanding mixed matrix membranes (MMMs) and thin film nanocomposites (TFNs) were prepared by incorporating porous silica nanosheets (SN) and exfoliated SN (E-SN) derived from natural vermiculite (Verm) in the PIM-1 polymer matrix. In addition, SN were functionalized by sulfonic acid and amine groups (S-SN and N-SN, respectively) and were also used as fillers for the preparation of MMMs. The gas separation performance was evaluated using CO2/CH4 and CO2/N2 (1:1, v:v) binary gas mixtures. Among freestanding membranes, fresh ones (i.e. tested right after preparation) containing 0.05 wt% functionalized SN and E-SN outperformed the neat PIM-1, surpassing the 2008 Robeson upper bound. At the same filler concentration, fresh MMMs with sulfonic acid-functionalized SN (S-SN) exhibited 40% higher CO2 permeability, 20% higher CO2/N2 selectivity and almost the same CO2/CH4 selectivity as neat PIM-1 membranes. Moreover, after 150 days of aging, these membranes were capable of maintaining up to 68% of their initial CO2 permeability (compared to 37% for neat PIM-1). When prepared as TFN membranes, the incorporation of 0.05 wt% of S-SN led to 35% higher initial CO2 permeance and five times higher CO2 permeance after 28 days

Aging of polymers of intrinsic microporosity studied by sorption and permeation

Polymers of intrinsic microporosity (PIMs)1 seem to be effective materials for gas and vapor separations.2 However, gas separation efficiency of PIMs can be strongly influenced by the material aging process connected with the changes of PIMs inner structure.3 With respect to potential industrial applications, the investigation of such changes and their effect on gas and vapor transport is necessary. In this work, we present a detailed study of i) CO2 sorption in PIM-1 via momentary measurements during four years and ii) methanol permeation in PIM-11 and EA-TB-PIM2 via continuous and momentary experiments. Sorption experiments were performed gravimetrically using a self-developed apparatus equipped with McBain’s spiral balances. In this case, PIM-1 membranes were pre-treated (soaking in ethanol with consequent drying at different temperatures) in order to study the influence of temperature on PIM-1 aging. Methanol permeation experiments were performed using a differential flow permeameter with H2 and He as carrier gases. Permeation experiment were performed with PIM-1 and PIM-EA-TB methanol treated membranes. CO2 sorption measurements revealed that, assuming the validity of the solution-diffusion model, the decrease of permeability during aging can be attributed directly to the decrease of diffusivity, whereas solubility is time independent in the studied period of four years. Although higher preparation temperature led to the initial drop of diffusivity, this process stabilized separation performance of PIMs over time (Figure 1). MeOH permeation experiments confirmed previous findings from CO2 tests, that the permeability decrease during the aging is a diffusivity controlled process. Moreover, it was found that the momentary permeation data can be mathematically transferred to continuous data, which are more relevant for applications but more difficult to measure. The nature of aging process was studied by infrared spectroscopy. We have found that aging of PIMs does not influence their chemical structure and; therefore, they undergo only the so called physical-aging. Please click Additional Files below to see the full abstract

Molecular Mobility and Gas Transport Properties of Mixed Matrix Membranes Based on PIM-1 and a Phosphinine Containing Covalent Organic Framework

Polymers with intrinsic microporosity (PIMs) are gaining attention as gas separation membranes. Nevertheless, they face limitations due to their pronounced physical aging. In this study, a covalent organic framework containing λ5-phosphinine moieties, CPSF-EtO, was incorporated as a nanofiller (concentration range 0–10 wt %) into a PIM-1 matrix forming dense films with a thickness of ca. 100 μm. The aim of the investigation was to investigate possible enhancements of gas transport properties and mitigating effects on physical aging. The incorporation of the nanofiller occurred on an nanoaggregate level with domains up to 100 nm, as observed by T-SEM and confirmed by X-ray scattering. Moreover, the X-ray data show that the structure of the microporous network of the PIM-1 matrix is changed by the nanofiller. As molecular mobility is fundamental for gas transport as well as for physical aging, the study includes dielectric investigations of pure PIM-1 and PIM-1/CPSF-EtO mixed matrix membranes to establish a correlation between the molecular mobility and the gas transport properties. Using the time-lag method, the gas permeability and the permselectivity were determined for N2, O2, CH4, and CO2 for samples with variation in filler content. A significant increase in the permeability of CH4 and CO2 (50% increase compared to pure PIM-1) was observed for a concentration of 5 wt % of the nanofiller. Furthermore, the most pronounced change in the permselectivity was found for the gas pair CO2/N2 at a filler concentration of 7 wt %

Outstanding performance of PIM-1 membranes towards the separation of fluorinated refrigerant gases

The recycling of depleted high global warming mixtures of fluorinated gases (F-gases) with close-boiling or azeotropic behavior requires advanced separation processes to obtain effectively the pure components. Herein, several types of PIM-1 membranes were tested for the first time towards the separation of hydrofluorocarbons and hydrofluoroolefins, showing extraordinarily high permeability coefficients for the value-added difluoromethane (R-32), up to 4100 barrer, coupled with high selectivity for the F-gas pairs of interest. Additionally, the solubility of selected F-gases in PIM-1 was measured and fitted to the dual-mode and Guggenheim, Anderson and de Boer sorption models. The separation performance of the standard PIM-1 and a highly branched PIM-1 was examined with the mixture R-410A (containing R-32 and pentafluoroethane R-125) to assess the influence of the membrane topology on the mixed-gas permeation properties over time (physical aging). Considering that the branched PIM-1 membrane was the least impacted by the aging phenomena, it was used to recover high purity R-32 (concentration in the permeate side as high as 98.9 vol % was achieved) from refrigerant gas mixtures R-410A and R-454B (mixture of R-32 and R-1234yf) in continuous long-term experiments. Results showed the great potential of PIM-1 membranes for the separation of R-32 from refrigerant mixtures collected from end-of-life equipment.This research is supported by project PID2019-105827RB-I00 funded by MCIN/AEI/10.13039/501100011033. F.P. and S.V.G.H. acknowledge the support of the Spanish State Research Agency and the Spanish Ministry of Science and Innovation (grants IJC2020-043134-I and PRE2020-093568, respectively). A.B.F and P.M.B acknowledge EPSRC Grant ep/v047078/1 (SynHiSel). P.G. is supported by Grant RYC2019-027060-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”

Aesthetics and literature : a problematic relation?

The paper argues that there is a proper place for literature within aesthetics but that care must be taken in identifying just what the relation is. In characterising aesthetic pleasure associated with literature it is all too easy to fall into reductive accounts, for example, of literature as merely "fine writing". Belleslettrist or formalistic accounts of literature are rejected, as are two other kinds of reduction, to pure meaning properties and to a kind of narrative realism. The idea is developed that literature-both poetry and prose fiction-invites its own distinctive kind of aesthetic appreciation which far from being at odds with critical practice, in fact chimes well with it

Recovery of free volume in PIM-1 membranes through alcohol vapor treatment

From Springer Nature via Jisc Publications RouterHistory: registration 2020-02-08, received 2020-06-24, accepted 2020-08-03, pub-electronic 2021-02-10, online 2021-02-10, pub-print 2021-08Publication status: PublishedAbstract: Physical aging is currently a major obstacle for the commercialization of PIM-1 membranes for gas separation applications. A well-known approach to reversing physical aging effects of PIM-1 membranes at laboratory scale is soaking them in lower alcohols, such as methanol and ethanol. However, this procedure does not seem applicable at industrial level, and other strategies must be investigated. In this work, a regeneration method with alcohol vapors (ethanol or methanol) was developed to recover permeability of aged PIM-1 membranes, in comparison with the conventional soaking-in-liquid approach. The gas permeability and separation performance, before and post the regeneration methods, were assessed using a binary mixture of CO2 and CH4 (1:1, v:v). Our results show that an 8-hour methanol vapor treatment was sufficient to recover the original gas permeability, reaching a CO2 permeability > 7000 barrer