Micronutrient deficiencies, vitamin pills and nutritional supplements

In the 21st century, it is hard to reconcile the concepts of the Western diet and overconsumption with the risk of micronutrient deficiencies. However, deficiencies can arise from poor dietary intake, alone or combined with physiological or metabolic injury. Micronutrients are essential to fulfil a broad range of biochemical and physiological functions, and are tightly regulated by homeostatic processes. Diagnosis of deficiency is complex and requires the use of separate investigations (dietary, functional, biochemical). While the role of micronutrients in the prevention or treatment of diseases (including cancer, type 2 diabetes) is of interest, a key driver for the vitamins and supplement market is their advertised potential to optimize health and performance in healthy individuals. The evidence so far indicates that multivitamins supplements offer no health protection, increase all-cause mortality, and risk of cancers in some subgroups. A nutritionally balanced diet is a safer way to achieve sufficiency

'Language is the source of misunderstandings'–impact of terminology on public perceptions of health promotion messages

Background: The high level of premature death due to non-communicable diseases has been associated with unhealthful lifestyles, including poor diet. The effectiveness of public health strategies designed to promote health via messages focusing on food and diets depends largely on the perception of the messages by the public. The aim of this study was to explore public perceptions of language commonly used to communicate concepts linking health, food and the diet.<p></p> Methods: This study is a qualitative and semi-quantitative cross-sectional survey exploring public perceptions of terms used to improve eating habits within public health strategies. We recruited adults with no background in nutrition or health-care, from May to July 2013, from urban areas of varying deprivation (n = 12) in Glasgow and Edinburgh, UK. Four key prompt-terms used to convey the idea of improving health through diet were selected for testing: Healthy Eating, Eating for Health, Balanced Diet and Nutritional Balance. Consumer understanding of these terms was explored using mixed-methods, including qualitative focus groups (n = 17) and an interviewer-led word-association exercise (n = 270).<p></p> Results: The word-association exercise produced 1,386 individual responses from the four prompt-terms, with 130 unique responses associated with a single term. Cluster analysis revealed 16 key themes, with responses affected by prompt-term used, age, gender and socio-economic status. Healthy Eating was associated with foods considered ‘healthy’ (p <0.05); Eating for Health and Balanced Diet with negative connotations of foods to avoid (both p <0.001) and Nutritional Balance with the benefits of eating healthily (p <0.01). Focus groups revealed clear differences in perceptions: Eating for Health = positive action one takes to manage existing medical conditions, Healthy Eating = passive aspirational term associated with weight management, Balanced Diet = old fashioned, also dieting for weight loss, Nutritional Balance = maximising physical performance. Food suppliers use Healthy Eating terminology to promote weight management products. Focus group participants welcomed product reformulation to enhance food health properties as a strategy to overcome desensitisation to health-messages.<p></p> Conclusions: Public perceptions of messages communicating concepts linking health, food and the diet are influenced by terminology, resulting in confusion. To increase individual commitment to change eating habits in the long term, public health campaigns need strengthening, potentially by investing in tailored approaches to meet the needs of defined groups of consumers

How architects incorporate ESD criteria into the design process

This paper will seek to answer; &quot;How do architects in Victoria incorporate Ecologically Sustainable Development (ESD) criteria into the design process?&quot; For the purpose of this paper, &quot;Ecologically Sustainable Development&quot; is defined in line with the judging criteria used by the Royal Australian Institute of Architects for the \u27Sustainable Architecture Award\u27. The RAIA states that (Maddison, 2003 p.7), &quot;the goal of sustainable architecture is to achieve development that improves the total quality of life, in a way that maintains the processes on which life depends. The project assessment covers ecologically sustainable development and energy efficient design:\u27 By researching exemplary building projects that have been awarded a Victorian Sustainable Architecture Award, this paper will enlighten a design methodology for the pursuit of excellence in ecologically sustainable development. Key elements in the design process will be determined by comparing and analysing the processes of different architectural practices. This will be achieved through the study of published literature on the award winning designs, qualitative analysis of interviews with the architects who designed the selected projects and quantitative analysis of questionnaires completed by the architects.<br /

A carbamazepine-indomethacin (1:1) cocrystal produced by milling

An X-ray amorphous mixture of carbamazepine and indomethacin transforms upon annealing to produce a novel 1:1 cocrystal, whose structure has been determined from laboratory powder X-ray diffraction (PXRD) data

Measuring antibody coatings on gold nanoparticles by optical spectroscopy

The adsorption of antibodies onto gold nanoparticles to make gold–antibody conjugates is finding application in multiple areas. Gold–antibody conjugates for use in malaria diagnostics were prepared and a method of characterisation that can be applied to any gold–protein conjugate was developed. When protein adsorbs onto a gold nanoparticle, it changes the local refractive index and so changes the surface plasmon resonance of the gold particle. Changes to the surface plasmon resonance manifest in the absorbance spectrum of the conjugates. This was measured by optical spectroscopy and relatively simple equations to convert spectral shifts to predictions of the protein layer thickness and mass coverage are presented. As with most protein adsorption reported in the literature, the results showed the protein adsorption to depend on antibody concentration, reaching a plateau at around 1 μg ml−1. The coverage was estimated to be approximately 2–3 mg m−2 and the coating thickness estimates were approximately 10 nm, which is consistent with active antibody. The results suggested more antibody was used in conjugate preparation than was necessary for complete coverage of the gold. This excess antibody could bind to the target antigen to reduce malaria test sensitivity. A key advantage of this characterisation method is that it is sufficiently simple to be used for quality control of conjugate production and the equations presented can be applied to other coatings on gold nanoparticles

Building capacity in waterbird and wetland monitoring in eastern Africa

The wetlands of eastern Africa support internationally important assemblages of plants and animals, and are a vital source of livelihood and water for many societies. The combined human population of Burundi, Djibouti, Eritrea, Ethiopia, Kenya, Rwanda, Sudan, Tanzania and Uganda is estimated to be about 200 million. The region has an area of about 5.6 million km2 of which only 4.5% is open water/wetlands. Wetland conversion to agriculture often provides only short-term benefits and can pose long-term problems. The ever-increasing human population density coupled with the scarce water resources in Africa have put African governments under increasing pressure to allow further exploitation and drainage of wetlands. Lack of sufficient up-to-date information to guide policy and development programmes for the respective Africa governments is considered as one of the causes for the continued loss and degradation of wetlands. To fill this information gap, it was recognized that a standardized system for monitoring wetland biodiversity and making the data and information available to governments and other stakeholders was required. In 2002, a project was implemented to build and maintain capacity in the monitoring of wetland biodiversity in eastern Africa and to provide the necessary information required for wetland conservation. This paper describes the capacity building process leading to: (1) the development of a wetlands database with query tools; (2) the provision of training in the use of the wetland monitoring database; (3) the launch of the Wetland Biodiversity Monitoring Scheme (WBMS) to provide data for use in wetland conservation and development of site management plans; and (4) training in the development of a wetland site management plan in each of the nine partner countries

Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders

INTRODUCTION: Nanosuspensions combine the advantages of nanotherapeutics (e.g. increased dissolution rate and saturation solubility) with ease of commercialisation. Transformation of nanosuspensions to solid oral and inhalable dosage forms minimises the physical instability associated with their liquid state, enhances patient compliance and enables targeted oral and pulmonary drug delivery. AREAS COVERED: This review outlines solidification methods for nanosuspensions. It includes spray and freeze drying as the most widely used techniques. Fluidised-bed coating, granulation and pelletisation are also discussed as they yield nanocrystalline formulations with more straightforward downstream processing to tablets or capsules. Spray-freeze drying, aerosol flow reactor and printing of nanosuspensions are also presented as promising alternative solidification techniques. Results regarding the solid state, in vitro dissolution and/or aerosolisation efficiency of the nanocrystalline formulations are given and combined with available in vivo data. Focus is placed on the redispersibility of the solid nanocrystalline formulations, which is a prerequisite for their clinical application. EXPERT OPINION: A few solidified nanocrystalline products are already on the market and many more are in development. Oral and inhalable nanoparticle formulations are expected to have great potential especially in the areas of personalised medicine and delivery of high drug doses (e.g. antibiotics) to the lungs, respectively

Preparation of respirable nanoparticle agglomerates of the low melting and ductile drug ibuprofen: impact of formulation parameters

Ductile and low melting point drugs exhibit challenging behaviour during both particle size reduction and spray drying as considerable amount of heat is involved in both processes. In this study, a systematic approach was employed to understand the preparation and in-vitro performance of respirable nanoparticle agglomerates by coupling wet milling and spray drying for ibuprofen, which is a drug with a low melting point and challenging mechanical properties. Wet milling in the presence of two stabilizers differing in their thermal properties and subsequent spray drying of the suspensions were employed after the addition of mannitol and/or leucine. The effects of the stabilizer type and the amounts of mannitol (matrix former) and leucine (dispersibility enhancer), on the yield of the process, the particle size, the redispersibility (i.e. reformation of nanoparticles upon rehydration) and the aerosolization (fine particle fraction, FPF%) of the nanoparticle agglomerates were evaluated using standard least squares model and a 23 full factorial design (3 factors at 2 levels plus four centre points). All factors investigated were found to have a significant effect on the yield of nanoparticle agglomerates (p < 0.05). The size of the nanoparticle agglomerates was mainly dependent on the leucine to drug ratio and the type of stabilizer (p < 0.05), while mannitol to drug ratio was the only significant factor affecting the redispersibility of the formulations (p < 0.05). The FPF%, determined using a fast screening impactor, was found to be dependent on both the leucine and mannitol to drug ratio (p < 0.05). This study demonstrates the successful preparation of respirable nanoparticle agglomerates of low melting point and ductile ibuprofen and the usefulness of the design of experiments as a tool to understand the impact of the formulation parameters on their fabrication and in-vitro performance