Evaluations of the sum-score-based and item response theory-based tests of group mean differences under various simulation conditions

The use of patient-reported outcomes measures is gaining popularity in clinical trials for comparing patient groups. Such comparisons typically focus on the differences in group means and are carried out using either a traditional sum-score-based approach or item response theory (IRT)-based approaches. Several simulation studies have evaluated different group mean comparison approaches in the past, but the performance of these approaches remained unknown under certain uninvestigated conditions (e.g. under the impact of differential item functioning (DIF)). By incorporating some of the uninvestigated simulation features, the current study examines Type I error, statistical power, and effect size estimation accuracy associated with group mean comparisons using simple sum scores, IRT model likelihood ratio tests, and IRT expected-a-posteriori scores. Manipulated features include sample size per group, number of items, number of response categories, strength of discrimination parameters, location of thresholds, impact of DIF, and presence of missing data. Results are summarized and visualized using decision trees

Valuation of Child Behavioral Problems from the Perspective of US Adults

To assess preferences between child behavioral problems and estimate their value on a quality-adjusted life year (QALYs) scale

Pre-diagnosis health-related quality of life, surgery, and survival in women with advanced epithelial ovarian cancer: A SEER-MHOS study

Health-related quality of life (HRQOL) has been found to be associated with overall survival in women with ovarian cancer. However, previous studies assessed HRQOL after surgery within clinical trial populations only. The study goal was to determine the association of pre-cancer diagnosis HRQOL with the likelihood of receiving surgery and with overall survival in a national, population-based cohort of older women with advanced ovarian cancer

Psychometric Properties of the Four-Item Morisky Green Levine Medication Adherence Scale among Atherosclerosis Risk in Communities (ARIC) Study Participants

To evaluate the reliability and factorial validity of the four-item Morisky Green Levine Medication Adherence Scale (MGLS) among Atherosclerosis Risk in Communities (ARIC) Study participants

A Systematic Review of Psychometric Properties of Health-Related Quality-of-Life and Symptom Instruments in Adult Acute Leukemia Survivors

Acute leukemia represents 4% of cancer cases in the United States (US) annually. There are over 302,000 people living with acute and chronic leukemia in the US. Treatment has been shown to have both positive and negative effects on health-related quality of life (HRQOL)

The Value Adults Place On Child Health And Functional Status

By summarizing the value adults place on child health and functional status, this study provides a new quantitative tool that enhances our understanding of the benefits of new health technologies and illustrates the potential contributions of existing datasets for comparative effectiveness research in pediatrics

Known-groups validity of the Patient-Reported Outcomes Measurement Information System (PROMIS®) in adolescents and young adults with special healthcare needs

To examine known-groups validity of the Patient-Reported Outcomes Measurement Information System (PROMIS®) Short Forms (SFs) for adolescents and young adults with special health care needs (SHCN) using data collected from the PROMIS Linking Study

Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors

Although racial disparities in health-related quality of life (HRQOL) among women with breast cancer (BC) are well documented, less is known about HRQOL changes over time among women of different races. Our objective was to assess racial differences in HRQOL during active treatment and survivorship phases of BC care

Associations of cancer and other chronic medical conditions with SF-6D preference-based scores in Medicare beneficiaries

Documenting the impact of different types of cancer on daily functioning and well-being is important for understanding burden relative to other chronic medical conditions. This study examined the impact of 10 different cancers and 13 other chronic medical conditions on health-related quality of life

A framework for improving early detection of breast cancer in sub-Saharan Africa: A qualitative study of help-seeking behaviors among Malawian women

Many women in Africa are diagnosed with advanced breast cancer. We explored Malawian breast cancer patients’ perspectives about their diagnosis and ability to access care to identify help-seeking behaviors and to describe factors influencing delay