The restorative role of annexin A1 at the blood–brain barrier

Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the peripheral body and CNS: the blood–brain barrier. In this review, we provide an overview of the role of this molecule in the brain, with a particular emphasis on its functions in the endothelium of the blood–brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS vasculature, and its potential for repairing blood–brain barrier damage in disease and aging

Search for dark matter candidates and large extra dimensions in events with a jet and missing transverse momentum with the ATLAS detector

Open Access, Copyright CERN, for the benefit of the ATLAS collaboration. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited

Interlaboratory comparison for heat transfer coefficient identification in hot stamping of high strength steels.

The topic of the paper is the identification of the heat transfer coefficient (HTC) in hot stamping of boron steel sheets under conditions very close to the industrial ones. Two approaches followed by one lab in Germany and one lab in Italy are presented for HTC identification, showing the two experimental apparatuses that were set-up to conduct the tests, the procedures developed and applied to identify the HTC. The obtained results are compared in terms of dependence of HTC from the applied contact pressure, the similarities and the differences of the two approaches are outlined and commented