A multiple criteria approach to map ecological-inclusive business models for sustainable development

The paper presents the first attempt to apply a multiple criteria approach to map ecological-inclusive business models and to structure their main features, in terms of sustainable development. Ecological-inclusive business models are presented in this study, and 15 cases pertaining to agro-food organisations located in Sub-Saharan Africa are considered. These companies simultaneously deliver positive social and environmental value, and confirm a well-established market presence. As far as social value is concerned, the companies included in the sample use a Bottom-of-Pyramid approach, involving low-income customers and/or low-income business partners. As for environmental value, all the analysed companies implement frugal innovation or sustainable exploitation of natural resources in the afro-food sector. One of the results that has been achieved is that of disentangling the complexity behind a triple bottom-line business model through a multidimensional analysis framework that identifies the aspects that play a fundamental role in ecological-inclusive business models. An evaluation model and the application of a multiple criteria outranking method are proposed as examples of how some criteria, such as the extent of socio-environmental concerns, strategy orientation and value of partnerships can be used to compare, rank and/or select business models to facilitate decision makers. This work presents the results of an interdisciplinary study on the social entrepreneurship field of knowledge

Computational approaches to shed light on molecular mechanisms in biological processes

Computational approaches based on Molecular Dynamics simulations, Quantum Mechanical methods and 3D Quantitative Structure-Activity Relationships were employed by computational chemistry groups at the University of Milano-Bicocca to study biological processes at the molecular level. The paper reports the methodologies adopted and the results obtained on Aryl hydrocarbon Receptor and homologous PAS proteins mechanisms, the properties of prion protein peptides, the reaction pathway of hydrogenase and peroxidase enzymes and the defibrillogenic activity of tetracyclines. © Springer-Verlag 2007

large strain extrusion machining of magnesium alloys for biomedical applications

Abstract Recently, magnesium alloys are attracting more and more attention as degradable materials for manufacturing temporary biomedical devices, although their rapid degradation in physiological environment limits their clinical applications to a great extent. Different Severe Plastic Deformation (SPD) processes have been recently applied to magnesium alloys in order to improve the surface integrity, which is directly correlated to their corrosion resistance. The current study investigates the possibility of exploiting Large Strain Extrusion Machining (LSEM) as a processing route to increase corrosion resistance of magnesium alloys for biomedical applications. Different cooling conditions and cutting speeds were adopted during LSEM and their effects on the surface integrity and corrosion resistance on both the machined workpiece and obtained chips were studied. For the first time, liquid nitrogen was used as cooling medium in LSEM and its effect was properly investigated. Results showed that LSEM, regardless of the adopted cutting parameters, is an effective method to obtain a workpiece with improved functional performances. Similar results pertain to the chips, but a careful choice of process parameters is even more mandatory than in the case of the workpiece

Satellite networking integration in the 5G ecosystem: Research trends and open challenges

The envisioned 5G ecosystem will be composed of heterogeneous networks based on different technologies and communication means, including satellite communication networks. The latter can help increase the capabilities of terrestrial networks, especially in terms of higher coverage, reliability, and availability, contributing to the achievement of some of the 5G KPIs. However, technological changes are not immediate. Many current satellite communication networks are based on proprietary hardware, which hinders the integration with future 5G terrestrial networks as well as the adoption of new protocols and algorithms. On the other hand, the two main paradigms that are emerging in the networking scenario \u2014 software defined networking (SDN) and network functions virtualization \u2014 can change this perspective. In this respect, this article presents first an overview of the main research works in the field of SDN satellite networks in order to understand the already proposed solutions. Then some open challenges are described in light of the network slicing concept by 5G virtualization, along with a possible roadmap including different network virtualization levels. The remaining unsolved problems are related to the development and deployment of a complete integration of satellite components in the 5G ecosystem

the effect of cooling strategies and machining feed rate on the corrosion behavior and wettability of az31 alloy for biomedical applications

Abstract In this work, the corrosion rate of the AZ31 magnesium alloy in physiological environment was improved by optimized machining process parameters. Cryogenic turning was exploited to obtain a featureless layer in the machined sub-surface, while the feed rate was modified to reduce the aspect ratio of the feed marks characteristic of the turning operation, achieving a decrease of the alloy wettability. The obtained results showed that the aforementioned combined aspects acted as an efficient strategy to enhance the AZ31 poor corrosion behavior, which represents the major obstacle of its effective application in the biomedical field

AB0292 EFFICACY AND SAFETY OF TWO BIOSIMILAR ETANERCEPT AFTER THE SWITCH FROM THEIR CORRESPONDING ORIGINATOR IN THE TREATMENT OF PATIENTS WITH AUTOIMMUNE ARTHRITIS; A RETROSPECTIVE ANALYSIS IN A REAL LIFE SETTING

Background:The available biosimilars of etanercept are as effective and well tolerated as their bio originator molecule in the naive treatment of chronic autoimmune arthritis. More data about the switching from the bio originator are needed.Objectives:To compare the clinical outcomes of the treatment with etanercept biosimilars (SB4 and GP2015) naïve and after the switch from their corresponding originator in patients affected by autoimmune arthritis in a real life settingMethods:We retrospectively analyzed the baseline characteristics and the retention rate in a cohort of patients who received at least a course of etanercept (originator or biosimilar) in our Rheumatology Units from January 2000 to January 2020. We stratified the study population according to biosimilar use. Descriptive data are presented by medians (interquartile range [IQR]) for continuous data or as numbers (percentages) for categorical data. Drug survival distribution curves were computed by the Kaplan-Meier method and compared by a stratified log-rank test. A Cox proportional hazards regression analysis stratified by indication, drug, age, disease duration, sex, treatment line, biosimilar use and prescription year was performed. P values≤0.05 were considered statistically significant.Results:477 patients (65% female, median age 56 [46-75] years, median disease duration 97 [40.25-178.75] months) treated with etanercept were included in the analysis. 257 (53.9%) were affect by rheumatoid arthritis, 139 (29.1%) by psoriatic arthritis, and 81 (17%) by axial spondylarthritis. 298 (62.5%) were treated with etanercept originator, 97 (20.3%) with SB4, and 82 (17.2%) with GP2015. Among the biosimilars 90/179 (50.3%) patients were naïve to etanercept treatment. Among the 89 switchers we observed 8 treatment discontinuations: one due to surgical infection complication, three due to disease flare, two due to subjective worsening and one due to remission. The overall 6- and 12-month retentions rate were 92.8% and 80.2%. The 6- and 12-month retention rate for etanercept, SB4 and GP2015 were 92.7%, 93.4% and 90.2%, and 82%, 74.5% and 88.1% respectively, without significant differences among the three groups (p=0.374). Patients switching from originator to biosimilars showed and overall higher treatment survival when compared to naive (12-month retention rate 81.2% vs 70.8%, p=0.036). The Cox proportional hazard regression analysis highlighted that the only predictor significantly associated with an overall higher risk of treatment discontinuation was the year of prescription (HR 1.08, 95% CI 1.04 to 1.13; p<0.0001).Conclusion:In our retrospective study etanercept originator and its biosimilars (SB4 and GP2015) showed the same effectiveness. Patients switching from originator to biosimilar showed an significant higher retention rate when compared to naive. The only predictor of treatment discontinuation highlighted by the Cox proportional hazard regression analysis was the year of treatment prescription.Disclosure of Interests:Francesco Girelli: None declared, Alarico Ariani: None declared, Marco Bruschi: None declared, Andrea Becciolini Speakers bureau: Sanofi-Genzyme, UCB and AbbVie, Lucia Gardelli: None declared, Maurizio Nizzoli: None declare

Metal(loid)s role in the pathogenesis of amyotrophic lateral sclerosis: Environmental, epidemiological, and genetic data

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder of the motor system. The etiology is still unknown and the pathogenesis remains unclear. ALS is familial in the 10% of cases with a Mendelian pattern of inheritance. In the remaining sporadic cases, a multifactorial origin is supposed in which several predisposing genes interact with environmental factors. The etiological role of environmental factors, such as pesticides, exposure to electromagnetic fields, and metals has been frequently investigated, with controversial findings. Studies in the past two decades have highlighted possible roles of metals, and ionic homeostasis dysregulation has been proposed as the main trigger to motor-neuron degeneration. This study aims at evaluating the possible role of environmental factors in etiopathogenesis of ALS, with a particular attention on metal contamination, focusing on the industrial Briga area in the province of Novara (Piedmont region, North Italy), characterized by: i) a higher incidence of sporadic ALS (sALS) in comparison with the entire province, and ii) the reported environmental pollution. Environmental data from surface, ground and discharge waters, and from soils were collected and specifically analyzed for metal content. Considering the significance of genetic mechanisms in ALS, a characterization for the main ALS genes has been performed to evaluate the genetic contribution for the sALS patients living in the area of study. The main findings of this study are the demonstration that in the Briga area the most common metal contaminants are Cu, Zn, Cr, Ni (widely used in tip-plating processes), that are above law limits in surface waters, discharge waters, and soil. In addition, other metals and metalloids, such as Cd, Pb, Mn, and As show a severe contamination in the same area. Results of genetic analyses show that sALS patients in the Briga area do not carry recurrent mutations or an excess of mutations in the four main ALS causative genes (SOD1, TARDBP, FUS, C9ORF72) and for ATXN2 CAG repeat locus. This study supports the hypothesis that the higher incidence of sALS in Briga area may be related to environmental metal(loid)s contamination, along with other environmental factors. Further studies, implementing analysis of genetic polymorphisms, as well as investigation with long term follow-up, may yield to key aspects into the etiology of ALS. The interplay between different approaches (environmental, chemical, epidemiological, genetic) of our work provides new insights and methodology to the comprehension of the disease etiology

A Novel Hierarchy of Integrable Lattices

In the framework of the reduction technique for Poisson-Nijenhuis structures, we derive a new hierarchy of integrable lattice, whose continuum limit is the AKNS hierarchy. In contrast with other differential-difference versions of the AKNS system, our hierarchy is endowed with a canonical Poisson structure and, moreover, it admits a vector generalisation. We also solve the associated spectral problem and explicity contruct action-angle variables through the r-matrix approach.Comment: Latex fil