53 research outputs found
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Joseph Haberer, De Descartes à Oppenheimer politique et communauté scientifique, 1969
Brunschwig Jeanne. Joseph Haberer, De Descartes à Oppenheimer politique et communauté scientifique, 1969. In: Raison présente, n°29, Janvier – Février – Mars 1974. L'intelligence est elle héréditaire ? pp. 117-119
Allemagne d'aujourd'hui
Brunschwig Jeanne. Allemagne d'aujourd'hui. In: Raison présente, n°50, Avril – Mai – Juin 1979. Idéologie et media aux U.S.A. pp. 137-138
L'interdiction professionnelle
Brunschwig Jeanne. L'interdiction professionnelle. In: Raison présente, n°48, Octobre – Novembre – Décembre 1978. Science, idéologie et politique. pp. 75-86
Joseph Haberer, De Descartes à Oppenheimer politique et communauté scientifique, 1969
Brunschwig Jeanne. Joseph Haberer, De Descartes à Oppenheimer politique et communauté scientifique, 1969. In: Raison présente, n°29, Janvier – Février – Mars 1974. L'intelligence est elle héréditaire ? pp. 117-119
Une rencontre Boukharine-Kamenev — Notes prises par Kamenev en 1928
Brunschwig Jeanne. Une rencontre Boukharine-Kamenev — Notes prises par Kamenev en 1928. In: Raison présente, n°54, 2e trimestre 1980. Violences et non-violence. pp. 55-66
Michel Beaud : Le système national mondial hiérarchisé, 1987
Brunschwig Jeanne. Michel Beaud : Le système national mondial hiérarchisé, 1987. In: Raison présente, n°86, 2e trimestre 1988. La Nation, réalités et fantasmes. pp. 161-165
Les Reaganiens contre l'Ă©cole publique
Brunschwig Jeanne. Les Reaganiens contre l'école publique. In: Raison présente, n°88, 4e trimestre 1988. Flash sur la droite. pp. 77-79
U.R.S.S. : de la contestation Ă l'opposition
Brunschwig Jeanne. U.R.S.S. : de la contestation à l'opposition. In: Raison présente, n°35, Juillet – Août – Septembre 1975. Raison mythe et société dans la Grèce antique. pp. 89-96
Bretrand Russell : Bertrand Russell, Pratique et théorie du bolchévisme
Brunschwig Jeanne. Bretrand Russell : Bertrand Russell, Pratique et théorie du bolchévisme. In: Raison présente, n°15, Juillet – Août – Septembre 1970. Enseignement recherche et société. pp. 121-123
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