4-(Pyrimidin-2-yl)-1-thia-4-aza­spiro­[4.5]decan-3-one

The title compound, C12H15N3OS, features an envelope conformation for the 1,3-thia­zolidin-4-one ring with the S atom as the flap atom. The pyrimidine ring is almost orthogonal to the 1,3-thia­zolidin-4-one ring as indicated by the N—C—C—N torsion angle of −111.96 (18)°. Supra­molecular dimers are formed in the crystal structure through the agency of C—H⋯O contacts occurring between centrosymmetrically related mol­ecules. These are linked into supra­molecular tapes along [100] via C—H⋯S contacts

Efficient sonothemical synthesis of thiazolidinones from piperonilamine

An efficient multicomponent reaction of arenealdehydes, mercaptoacetic acid and piperonilamine under ultrasound irradiation to afford 2-aryl-3-(piperonylmethyl)-1,3-thiazolidin-4-ones is reported. Applying this methodology, eleven heterocycles were synthesized and isolated in good yields after short reaction times. (C) 2010 Elsevier B.V. All rights reserved