Generalized Aharonov-Bohm effect, homotopy classes and Hausdorff dimension

We suggest as gedanken experiment a generalization of the Aharonov-Bohm experiment, based on an array of solenoids. This experiment allows in principle to measure the decomposition into homotopy classes of the quantum mechanical propagator. This yields information on the geometry of the average path of propagation and allows to determine its Hausdorff dimension.Comment: 14 pages, LaTeX + 3 figures, P

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain

UvrD is a helicase vital for DNA replication and quality control processes. In its monomeric state, UvrD exhibits limited helicase activity, necessitating either dimerization or assistance from an accessory protein to efficiently unwind DNA. Within the DNA mismatch repair pathway, MutL plays a pivotal role in relaying the repair signal, enabling UvrD to unwind DNA from the strand incision site up to and beyond the mismatch. Although this interdependence is well-established, the precise mechanism of activation and the specific MutL-UvrD interactions that trigger helicase activity remain elusive. To address these questions, we employed site-specific crosslinking techniques using single-cysteine variants of MutL and UvrD followed by functional assays. Our investigation unveils that the C-terminal domain of MutL not only engages with UvrD but also acts as a self-sufficient activator of UvrD helicase activity on DNA substrates with 3′-single-stranded tails. Especially when MutL is covalently attached to the 2B or 1B domain the tail length can be reduced to a minimal substrate of 5 nucleotides without affecting unwinding efficiency.</p

Exogenous volatility and the size of government in developing countries

This paper presents instrumental variables estimates of the effects of GDP per capita volatility on the size of government. We show that for a panel of 157 countries spanning more than half a century, rainfall volatility has a significant positive effect on GDP per capita volatility in countries with above median temperatures. In these countries rainfall volatility has also a significant positive reduced-form effect on the GDP share of government. There is no significant reduced-form effect in the sample of countries with below median temperatures where rainfall volatility has no significant effect on GDP per capita volatility. Using rainfall volatility as an instrumental variable in the sample of countries with above median temperatures yields that greater GDP per capita volatility leads to a significantly higher GDP share of government

MutL Activates UvrD by Interaction Between the MutL C-terminal Domain and the UvrD 2B Domain

UvrD is a helicase vital for DNA replication and quality control processes. In its monomeric state, UvrD exhibits limited helicase activity, necessitating either dimerization or assistance from an accessory protein to efficiently unwind DNA. Within the DNA mismatch repair pathway, MutL plays a pivotal role in relaying the repair signal, enabling UvrD to unwind DNA from the strand incision site up to and beyond the mismatch. Although this interdependence is well-established, the precise mechanism of activation and the specific MutL-UvrD interactions that trigger helicase activity remain elusive. To address these questions, we employed site-specific crosslinking techniques using single-cysteine variants of MutL and UvrD followed by functional assays. Our investigation unveils that the C-terminal domain of MutL not only engages with UvrD but also acts as a self-sufficient activator of UvrD helicase activity on DNA substrates with 3′-single-stranded tails. Especially when MutL is covalently attached to the 2B or 1B domain the tail length can be reduced to a minimal substrate of 5 nucleotides without affecting unwinding efficiency.</p

Oceanic crust generated by elusive parents: Sr/Nd isotopes in basalt-peridotite pairs from the Mid-Atlantic Ridge

Given that oceanic basalts form by partial melting of mantle peridotites that rise below mid-ocean ridges, peridotite and basalt should have identical Sr and Nd isotope ratios.We tested this concept on parallel sets of peridotites and basalts sampled from an exposed section of lithosphere representing 20 m.y. of accretion at the Mid-Atlantic Ridge. The 143Nd/144Nd ratios of the basaltic glasses stay constant, whereas those of the peridotitic clinopyroxenes extend both higher and lower than the basalt ratios, suggesting that the constant isotopic composition of the basalts results from mixing of melts released by peridotitesfrom a broad region of the subridge mantle. The degree of melting undergone by the peridotites correlates inversely with their 143Nd/144Nd ratios. Small-scale isotopic heterogeneity of the peridotites may result from variable premelting metasomatism in the mantle, mostly during periodic, dynamic, subridge upwelling, possibly superimposed upon time-integrated radioactive decay of ancient heterogeneities

Results of the struggle at ancient Ephesus: natural processes 1, human intervention 0

WOS: 000288755200004Coastal areas have been prime locations for habitation and commerce. Early authors such as Pausanias (second century CE), and Strabo (64 or 63 BCE-24 CE) noted the impacts of shoreline changes. Geomorphological and subsurface geological data, combined with archaeological excavation and ancient texts, indicate a long interplay between natural processes of estuarine infilling by sediments from the Kucuk Menderes River (ancient Cayster River) and multiple attempts of human intervention to preserve the harbours of Ephesus. Strabo noted that harbour engineering efforts there, such as the construction of a mole to prevent siltation, instead created a sediment trap that made things worse. The pre-Holocene river valley was inundated by Holocene sea-level rise that formed the ancient Gulf of Ephesus. Extensive palaeogeographical studies, based on sediment coring, geomorphology, archaeology and history, have provided details of the problems the inhabitants faced in keeping vital harbours in operation. Dating and analysis of sedimentary deposits has allowed the description of shifting river courses, floodplain changes, human intervention, and anthropogenic deposits at Ephesus. During and following Classical times sediment deposition rapidly began to fill in the embayment, requiring the inhabitants to regularly shift the harbours westward. Ultimately, it was to no avail