Modified Heritage

There are evidences of a rich history and heritage that centers around a once thriving African-American community in the late 1800’s and the early 1900’s. These thriving communities can also be called freedom colonies. These were post-emancipation settlements where African-Americans would intentionally begin to erect almost self-governing settlements with in-grown economics, education of the community, and a church that acted as an epicenter of refuge, initiative, and change. The project attempts to recognize these elements of empowerment within this context and zooms in even more so to the manifestation of black heritage in Washington County. How do we recognize the relationship between grounding the project in a particular vernacular context, yet instigate a slight deviance? How do we critically view the history of a black vernacular narrative arc both within Washington County and abroad, to both recognize it and modify it to contemporary interpretations? How do we negotiate how a project is fixed in time, yet understand the ascribed meanings and values may have changed, and will continue to change within the community? There are foundational truths to which this heritage has been built on with other layers of resilience following. This final study project provides a sketch to the possibilities of the intersection between a strong cultural discourse and the architectural environment. It attempts to delineate a past call, provide a present response, and initiate progress toward a modified future

Cloud privacy and security issues beyond technology: championing the cause of accountability

Cloud computing provides IT service providers increased efficiency of resource utilization while enabling consumers to benefit from innovative advantages like access to up-to-date IT resources and low upfront investment. A significant hindrance to adoption of cloud computing is the lack of trust arising from worries over privacy and security when data resources of cloud service consumers are handled by third parties. A key factor in fostering cloud privacy and security is accountability, which increases trust by obligating an entity to be answerable for its actions. This paper uses a hermeneutic literature review to investigate (i) the prevailing methods and strategies of fostering privacy and security through accountability, (ii) the key actors in championing cloud accountability and (iii) the key barriers to cloud accountability. This literature review provides insight into current practices associated with championing cloud accountability and contributes to cloud service provider awareness of ways to improve cloud computing trustworthiness

Housing Affordability Index: Mountain West Cities, November 2021

This fact sheet highlights data on the median household income, median home price, estimated monthly mortgage and taxes, and share of income used for homeownership in fifteen Mountain West housing markets, as originally outlined in the “RealtyHop Housing Affordability Index: November 2021” report. The RealtyHop report analyzes the affordability of housing markets for the 100 most populous cities in the United States

The sloppy model universality class and the Vandermonde matrix

In a variety of contexts, physicists study complex, nonlinear models with many unknown or tunable parameters to explain experimental data. We explain why such systems so often are sloppy; the system behavior depends only on a few `stiff' combinations of the parameters and is unchanged as other `sloppy' parameter combinations vary by orders of magnitude. We contrast examples of sloppy models (from systems biology, variational quantum Monte Carlo, and common data fitting) with systems which are not sloppy (multidimensional linear regression, random matrix ensembles). We observe that the eigenvalue spectra for the sensitivity of sloppy models have a striking, characteristic form, with a density of logarithms of eigenvalues which is roughly constant over a large range. We suggest that the common features of sloppy models indicate that they may belong to a common universality class. In particular, we motivate focusing on a Vandermonde ensemble of multiparameter nonlinear models and show in one limit that they exhibit the universal features of sloppy models.Comment: New content adde

Reply to Comment on “Sloppy models, parameter uncertainty, and the role of experimental design"

available in PMC 2012 November 10.We welcome the commentary from Chachra, Transtrum, and Sethna1 regarding our paper “Sloppy models, parameter uncertainty, and the role of experimental design,”2 as their intriguing work shaped our thinking in this area.3 Sethna and colleagues introduced the notion of sloppy models, in which the uncertainty in the values of some combinations of parameters is many orders of magnitude greater than others.4 In our work we explored the extent to which large parameter uncertainties are an intrinsic characteristic of systems biology network models, or whether uncertainties are instead closely related to the collection of experiments used for model estimation. We were gratified to find the latter result –– that parameters are in principle knowable, which is important for the field of systems biology. The work also showed that small parameter uncertainties can be achieved and that the process can be greatly accelerated by using computational experimental design approaches5–9 deployed to select sets of experiments that effectively exercise the system in complementary directions

Diverse and tissue-enriched small RNAs in the plant pathogenic fungus, Magnaporthe oryzae

<p>Abstract</p> <p>Background</p> <p>Emerging knowledge of the impact of small RNAs as important cellular regulators has prompted an explosion of small transcriptome sequencing projects. Although significant progress has been made towards small RNA discovery and biogenesis in higher eukaryotes and other model organisms, knowledge in simple eukaryotes such as filamentous fungi remains limited.</p> <p>Results</p> <p>Here, we used 454 pyrosequencing to present a detailed analysis of the small RNA transcriptome (~ 15 - 40 nucleotides in length) from mycelia and appressoria tissues of the rice blast fungal pathogen, <it>Magnaporthe oryzae</it>. Small RNAs mapped to numerous nuclear and mitochondrial genomic features including repetitive elements, tRNA loci, rRNAs, protein coding genes, snRNAs and intergenic regions. For most elements, small RNAs mapped primarily to the sense strand with the exception of repetitive elements to which small RNAs mapped in the sense and antisense orientation in near equal proportions. Inspection of the small RNAs revealed a preference for U and suppression of C at position 1, particularly for antisense mapping small RNAs. In the mycelia library, small RNAs of the size 18 - 23 nt were enriched for intergenic regions and repetitive elements. Small RNAs mapping to LTR retrotransposons were classified as LTR retrotransposon-siRNAs (LTR-siRNAs). Conversely, the appressoria library had a greater proportion of 28 - 35 nt small RNAs mapping to tRNA loci, and were classified as tRNA-derived RNA fragments (tRFs). LTR-siRNAs and tRFs were independently validated by 3' RACE PCR and northern blots, respectively.</p> <p>Conclusions</p> <p>Our findings suggest <it>M. oryzae </it>small RNAs differentially accumulate in vegetative and specialized-infection tissues and may play an active role in genome integrity and regulating growth and development.</p

Race-Ethnic Population Changes in Mountain West Metros, 2010-2020

The 2020 census shows continuing nationwide trends in population growth when compared to the last decade. The growth of various race-ethnic groups across the country contribute to the diversification of the population in selected regions. Using the U.S. Census Bureau 2020 data prepared by William H. Frey of the Brookings Institution, this fact sheet focuses on the population changes in nine Mountain West metros