Conscious, deliberate, and purposeful living: Lessons from the adult daughters of psychiatrized women

The following document details the intellectual and emotional journey I embarked on when I chose to cross the subject-object divide by exploring a phenomenon with which I had direct lived experience. Incorporating feminist multiple interviewing techniques, participatory action learning. and critical autobiography. I sought to examine what it means to be the adult daughter of a woman who has been labelled and treated by the psychiatric profession (i.e., who has been psychiatrized). I begin with an exploration of the “phenomenon” as it is presented in the literature. To orient the reader I offer a description of what I believe are the prevailing and competing paradigms available to conceptualize human health and well being. I then explore the literature specifically addressing the children of people diagnosed and treated within the psychiatric system, with reference to how the research reflects dominant and marginal paradigms in health. The theoretical framework that I drew upon to understand and construct this thesis incorporates aspects of critical social science theory, feminist positionality, theoretical autobiography, and research for social justice. Underlying this “non-unitary framework is the assumption that all knowledge is situated, partial, and constructed and that the “knowledge creation enterprise” should be aimed at providing space for the articulation and legitimization of marginalized voices. Qualitative and inductive methods privileging the voices of participants were deemed to be the most effective means by which to bring marginalized voices to the foreground. Case-studies. or individual stories form the basis of the research findings, as I offer a series of six personal stories from young women whose mothers have been psychiatrized. These stories are organized to emphasize the chronology of the women’s experiences, their interpretations of those experiences, and the role of their interpretations played in influencing their future choices, self-concept, and behaviour. Seeking to situate the participants’ experiences in the larger social and political context, I also present a detailed cross-case analysis and interpretation of findings incorporating a feminist and anti-oppression perspective. Based on the rich and detailed information that was generated by this project, I developed a model to guide what I call “conscious living.” It offers some conceptual tools for understanding the relationship between individual health and well being and the larger environmental context (i.e., broadly defined). Moreover, within this guide I offer the reader suggestions for intervention at multiple levels within the social ecology. The values, visions, and practice of Community Psychology figure prominently in the guide that I offer

Science Fiction at Georgia Tech: Linking STEM, Humanities, and Archives

The Science Fiction Collection at the Georgia Institute of Technology (Georgia Tech) is a major component of the instruction, research, and outreach events involving the archives, the library, campus, and local communities. Collaborative efforts between archivists and librarians have stimulated growth of the physical and digital archival and circulating science fiction collections and have helped bridge the divide between a largely science, technology, engineering, and math (STEM)focused campus and the humanities. Sherri Brown, former subject librarian forthe School of Literature, Media and Communication (LMC), and Jody Thompson,head of archives, are two of the key players in the growth, outreach, instruction,and use of the collection. This case study highlights how this collection has been collaboratively cultivated and how it works as an essential resource in meeting the teaching, research, and learning goals of the library and the archives

Perceptions of the Great Northern Forest & its Management

CaRDI Research & Policy Brief Issue 4

2007 Statewide Deer Hunter Survey: Participation During the ’06 Seasons, Opinions about Hot-Button Issues, and Trends in Characteristics of Hunters

Click on the PDF for an Executive Summary and the full report. Visit the HDRU website for a complete listing of HDRU publications at: http://hdru.dnr.cornell.edu

Hunter Participation in Quality Hunting Ecology in Pennsylvania: Baseline Research

Click on the PDF for an Executive Summary and the full report. Visit the HDRU website for a complete listing of HDRU publications at: http://hdru.dnr.cornell.edu

Preliminary Assessment of Social Feasibility for Reintroducing Gray Wolves to the Adirondack Park in Northern New York

Click on the PDF for an Executive Summary and the full report. Visit the HDRU website for a complete listing of HDRU publications at: http://hdru.dnr.cornell.edu

Landowner and Hunter Response to Implementation of a Quality Deer Management (QDM) Cooperative Near King Ferry, New York

Click on the PDF for an Executive Summary and the full report. Visit the HDRU website for a complete listing of HDRU publications at: http://hdru.dnr.cornell.edu

TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurodegeneration is evident, but the underlying molecular events are not well defined. Human non-mutated 0N4R tau (tauWT) and P301L mutant 0N4R tau (tauP301L) were expressed in mouse primary cortical neurons using adeno-associated viruses to monitor early molecular changes and synaptic function before the onset of neuronal loss. In this model tauP301L was differentially phosphorylated relative to tauwt with a notable increase in phosphorylation at ser262. Affinity purification - mass spectrometry combined with tandem mass tagging was used to quantitatively compare the tauWT and tauP301L interactomes. This revealed an enrichment of tauP301L with ribosomal proteins but a decreased interaction with the proteasome core complex and reduced tauP301L degradation. Differences in the interaction of tauP301L with members of a key synaptic calcium-calmodulin signalling pathway were also identified, most notably, increased association with CaMKII but reduced association with calcineurin and the candidate AD biomarker neurogranin. Decreased association of neurogranin to tauP301L corresponded with the appearance of enhanced levels of extracellular neurogranin suggestive of potential release or leakage from synapses. Finally, analysis of neuronal network activity using micro-electrode arrays showed that overexpression of tauP301L promoted basal hyperexcitability coincident with these changes in the tau interactome and implicating tau in specific early alterations in synaptic function

TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurodegeneration is evident, but the underlying molecular events are not well defined. Human non-mutated 0N4R tau (tauWT) and P301L mutant 0N4R tau (tauP301L) were expressed in mouse primary cortical neurons using adeno-associated viruses to monitor early molecular changes and synaptic function before the onset of neuronal loss. In this model tauP301L was differentially phosphorylated relative to tauwt with a notable increase in phosphorylation at ser262. Affinity purification - mass spectrometry combined with tandem mass tagging was used to quantitatively compare the tauWT and tauP301L interactomes. This revealed an enrichment of tauP301L with ribosomal proteins but a decreased interaction with the proteasome core complex and reduced tauP301L degradation. Differences in the interaction of tauP301L with members of a key synaptic calcium-calmodulin signalling pathway were also identified, most notably, increased association with CaMKII but reduced association with calcineurin and the candidate AD biomarker neurogranin. Decreased association of neurogranin to tauP301L corresponded with the appearance of enhanced levels of extracellular neurogranin suggestive of potential release or leakage from synapses. Finally, analysis of neuronal network activity using micro-electrode arrays showed that overexpression of tauP301L promoted basal hyperexcitability coincident with these changes in the tau interactome and implicating tau in specific early alterations in synaptic function