Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes

Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation. While typically asymptomatic, HCMV can cause fatal disease among congenitally infected infants and immunocompromised patients. These clinical issues are compounded by the emergence of antiviral resistance and the absence of an effective vaccine, the development of which is likely complicated by the numerous immune evasins encoded by HCMV to counter the host's adaptive immune responses, a feature that facilitates frequent super-infections. Understanding the evolutionary dynamics of HCMV is essential for the development of effective new drugs and vaccines. By comparing viral genomes from uncultivated or low-passaged clinical samples of diverse origins, we observe evidence of frequent homologous recombination events, both recent and ancient, and no structure of HCMV genetic diversity at the whole-genome scale. Analysis of individual gene-scale loci reveals a striking dichotomy: while most of the genome is highly conserved, recombines essentially freely and has evolved under purifying selection, 21 genes display extreme diversity, structured into distinct genotypes that do not recombine with each other. Most of these hyper-variable genes encode glycoproteins involved in cell entry or escape of host immunity. Evidence that half of them have diverged through episodes of intense positive selection suggests that rapid evolution of hyper-variable loci is likely driven by interactions with host immunity. It appears that this process is enabled by recombination unlinking hyper-variable loci from strongly constrained neighboring sites. It is conceivable that viral mechanisms facilitating super-infection have evolved to promote recombination between diverged genotypes, allowing the virus to continuously diversify at key loci to escape immune detection, while maintaining a genome optimally adapted to its asymptomatic infectious lifecycle

MSIS 2016: a comprehensive update of graduate level curriculum recommendation in Information Systems

The process to revise MSIS 2006, the master's level curriculum recommendation for Information Systems, is getting close to completion. In spring and summer 2016, the joint AIS/ACM task force will continue the process of soliciting comments from various stakeholders, including the academic IS community and employers. The purpose of the AMCIS panel is to give the audience an update of the status of the MSIS 2016 revision process and provide the task force with feedback regarding the draft document. A significant portion of the session will be reserved for conversation. The task force is proposing significant changes to the curriculum content and structure, including the new curriculum's focus on specifying desired graduate competencies instead of articulating courses or knowledge areas/units. Some of the changes are a reflection of the changes in the process used to revise the curriculum: MSIS 2016 will be a result of a truly global process.The MSIS 2016 task force thanks all members of the IS community and other stakeholders of the project for all the invaluable feedback and comments we have received throughout the process.info:eu-repo/semantics/publishedVersio

MSIS 2016 global competency model for graduate degree programs in information systems

[Extract] This document, “MSIS 2016: Global Competency Model for Graduate Degree Programs in Information Systems”, is the latest in the series of reports that provides guidance for degree programs in the Information Systems (IS) academic discipline. MSIS 2016 is the seventh collaborative effort between ACM and AIS (following IS’97, IS 2002, and IS 2010 at the undergraduate level; MSIS 2000 and MSIS 2006 at the graduate level; and CC 2005 as an integrative document).(undefined)info:eu-repo/semantics/publishedVersio

Master’s degree programs in information systems: a global view

In this paper, we present an analysis of 254 master's degree programs in Information Systems, offered by 229 universities in 32 countries. The entry requirements usually include a Bachelor's degree in IS or a related subject. In some countries such as USA any kind of Bachelor's degree is acceptable. In a few countries significant relevant work experience can replace or supplement the BSc. The duration of the degrees varies between one to two years, with the student workload between 1350-3200 hours. If we take into consideration the differences in entering the program (from none to four years of IS studies), the gap grows considerably. Most programs require course work in both computing and a domain of practice (such as business), but some have no requirements related to the domain of practice and still others have only modest computing requirements. Degrees with a professional orientation emphasize industry projects and internships, while in several countries a thesis is an essential part of the degree thereby preparing for further studies. A thesis also trains for reading and writing academic papers, thus enabling graduates to tap into current research in their daily work. The variation amongst programs presents a concern for the image of IS as a profession and a challenge for recruiters. The results are discussed in the context of an ongoing project to revise the graduate level model curriculum in Information Systems, with a particular emphasis on the IS profession.(undefined)info:eu-repo/semantics/publishedVersio

Current MSIS students' views on program outcomes

This paper reports the results of a pilot survey sent to current specialized master's students in Information Systems at several universities around the world. The survey was developed to support the MSIS revision process, but the results will also provide insights on the perceptions of current IS master's students regarding their current degree program. The results suggest that the respondents valued individual foundational skills and high-level business competences more than technical or lower-level managerial competences. The study utilized competence specifications from the European e-CF 3.0 model, which was useful and performed well as a competence framework.(undefined)info:eu-repo/semantics/publishedVersio

Revising the MSIS 2016 model curriculum: status update and panel discussion

This panel discussion will provide an update of the ongoing work to revise the ACM/AIS graduate level curriculum recommendation for Information Systems (MSIS). The panel will consist of the members of the task force, who will report on a) changes in the direction of the task force's work since summer 2015 position paper; b) results of the fall 2015 data collection; and c) key decisions regarding the curriculum architecture made by the time of the panel. A major part of the panel will be reserved for open discussion and participant feedback, which will directly impact the work of the task force.(undefined)info:eu-repo/semantics/publishedVersio

Revising the MSIS 2016 model curriculum: status update and panel discussion

This panel discussion will provide an update of the ongoing work to revise the ACM/AIS graduate level curriculum recommendation for Information Systems (MSIS). The panel will consist of the members of the task force, who will report on a) changes in the direction of the task force's work since summer 2015 position paper; b) results of the fall 2015 data collection; and c) key decisions regarding the curriculum architecture made by the time of the panel. A major part of the panel will be reserved for open discussion and participant feedback, which will directly impact the work of the task force.(undefined)info:eu-repo/semantics/publishedVersio

Current MSIS students\u27 views on program outcomes

This paper reports the results of a pilot survey sent to current specialized master’s students in Information Systems at several universities around the world. The survey was developed to support the MSIS revision process, but the results will also provide insights on the perceptions of current IS master’s students regarding their current degree program. The results suggest that the respondents valued individual foundational skills and high-level business competences more than technical or lower-level managerial competences. The study utilized competence specifications from the European e-CF 3.0 model, which was useful and performed well as a competence framework

The OptiMine feasibility study: a novel implementation strategy to electronically screen and signpost patients to health behaviour apps

Background: Behavior change apps have the potential to provide individual support on a population scale at low cost, but they face numerous barriers to implementation. Electronic health records (EHRs) in acute care hospitals provide a valuable resource for identifying patients at risk, who may benefit from behavior change apps. A novel, emerging implementation strategy is to use digital technologies not only for providing support to help-seeking individuals but also for signposting patients at risk to support services (also called proactive referral in the United States). Objective: The OptiMine study aimed to increase the reach of behavior change apps by implementing electronic signposting for smoking cessation and alcohol reduction in a large, at-risk population that was identified through an acute care hospital EHR. Methods: This 3-phase, mixed methods implementation study assessed the acceptability, feasibility, and reach of electronic signposting to behavior change apps by using a hospital’s EHR system to identify patients who are at risk. Phase 1 explored the acceptability of the implementation strategy among the patients and staff through focus groups. Phase 2 investigated the feasibility of using the hospital EHR to identify patients with target risk behaviors and contact them via SMS text message, email, or patient portal. Phase 3 assessed the impact of SMS text messages sent to patients who were identified as smokers or risky drinkers, which signposted them to behavior change apps. The primary outcome was the proportion of participants who clicked on the embedded link in the SMS text message to access information about the apps. The acceptability of the SMS text messages among the patients who had received them was also explored in a web-based survey. Results: Our electronic signposting strategy—using SMS text messages to promote health behavior change apps to patients at risk—was found to be acceptable and feasible and had good reach. The hospital sent 1526 SMS text messages, signposting patients to either the National Health Service Smokefree or Drink Free Days apps. A total of 13.56% (207/1526) of the patients clicked on the embedded link to the apps, which exceeded our 5% a priori success criterion. Patients and staff contributed to the SMS text message content and delivery approach, which were perceived as acceptable before and after the delivery of the SMS text messages. The feasibility of the SMS text message format was determined and the target population was identified by mining the EHR. Conclusions: The OptiMine study demonstrated the proof of concept for this novel implementation strategy, which used SMS text messages to signpost at-risk individuals to behavior change apps at scale. The level of reach exceeded our a priori success criterion in a non–help-seeking population of patients receiving unsolicited SMS text messages, disconnected from hospital visits. International Registered Report Identifier (IRRID): RR2-10.2196/2366

Novel implementation strategy to electronically screen and signpost patients to health behavior apps: Mixed methods implementation study (OptiMine study)

BACKGROUND: Behavior change apps have the potential to provide individual support on a population scale at low cost, but they face numerous barriers to implementation. Electronic health records (EHRs) in acute care hospitals provide a valuable resource for identifying patients at risk, who may benefit from behavior change apps. A novel, emerging implementation strategy is to use digital technologies not only for providing support to help-seeking individuals but also for signposting patients at risk to support services (also called proactive referral in the United States). OBJECTIVE: The OptiMine study aimed to increase the reach of behavior change apps by implementing electronic signposting for smoking cessation and alcohol reduction in a large, at-risk population that was identified through an acute care hospital EHR. METHODS: This 3-phase, mixed methods implementation study assessed the acceptability, feasibility, and reach of electronic signposting to behavior change apps by using a hospital\u27s EHR system to identify patients who are at risk. Phase 1 explored the acceptability of the implementation strategy among the patients and staff through focus groups. Phase 2 investigated the feasibility of using the hospital EHR to identify patients with target risk behaviors and contact them via SMS text message, email, or patient portal. Phase 3 assessed the impact of SMS text messages sent to patients who were identified as smokers or risky drinkers, which signposted them to behavior change apps. The primary outcome was the proportion of participants who clicked on the embedded link in the SMS text message to access information about the apps. The acceptability of the SMS text messages among the patients who had received them was also explored in a web-based survey. RESULTS: Our electronic signposting strategy-using SMS text messages to promote health behavior change apps to patients at risk-was found to be acceptable and feasible and had good reach. The hospital sent 1526 SMS text messages, signposting patients to either the National Health Service Smokefree or Drink Free Days apps. A total of 13.56% (207/1526) of the patients clicked on the embedded link to the apps, which exceeded our 5% a priori success criterion. Patients and staff contributed to the SMS text message content and delivery approach, which were perceived as acceptable before and after the delivery of the SMS text messages. The feasibility of the SMS text message format was determined and the target population was identified by mining the EHR. CONCLUSIONS: The OptiMine study demonstrated the proof of concept for this novel implementation strategy, which used SMS text messages to signpost at-risk individuals to behavior change apps at scale. The level of reach exceeded our a priori success criterion in a non-help-seeking population of patients receiving unsolicited SMS text messages, disconnected from hospital visits. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/23669