Cosmic Attractors and Gauge Hierarchy

We suggest a new cosmological scenario which naturally guarantees the smallness of scalar masses and VEVs, without invoking supersymmetry or any other (non-gravitationaly coupled) new physics at low energies. In our framework, the scalar masses undergo discrete jumps due to nucleation of closed branes during (eternal) inflation. The crucial point is that the step size of variation decreases in the direction of decreasing scalar mass. This scenario yields exponentially large domains with a distribution of scalar masses, which is sharply peaked around a hierarchically small value of the mass. This value is the "attractor point" of the cosmological evolution

Shock Migration on an Oscillating Straked Delta Wing Using an Unsteady Euler Solver

This research contributes to the understanding of Shock Induced Trailing Edge Separation (SITES) as a driver of Limit Cycle Oscillation (LCO) by performing a computational investigation of nonlinear aerodynamic phenomena on a straked delta wing in transonic flow, oscillating in pitch. ZEUS, an Euler-based aeroelastic solver with a boundary layer coupling scheme meant to capture viscous flow effects within the boundary layer, was used to analyze aerodynamic flow around the wing for various mean incidence angles, oscillation amplitudes, and Mach numbers within the transonic region. The dynamic characteristics of the airflow around the wing were investigated in order to characterize shock movement

Probing the Inner Regions of Protoplanetary Disks with CO Absorption Line Spectroscopy

Carbon monoxide (CO) is the most commonly used tracer of molecular gas in the inner regions of protoplanetary disks. CO can be used to constrain the excitation and structure of the circumstellar environment. Absorption line spectroscopy provides an accurate assessment of a single line-of-sight through the protoplanetary disk system, giving more straightforward estimates of column densities and temperatures than CO and molecular hydrogen emission line studies. We analyze new observations of ultraviolet CO absorption from the Hubble Space Telescope along the sightlines to six classical T Tauri stars. Gas velocities consistent with the stellar velocities, combined with the moderate-to-high disk inclinations, argue against the absorbing CO gas originating in a fast-moving disk wind. We conclude that the far-ultraviolet observations provide a direct measure of the disk atmosphere or possibly a slow disk wind. The CO absorption lines are reproduced by model spectra with column densities in the range N(^{12}CO) ~ 10^{16} - 10^{18} cm^{-2} and N(^{13}CO) ~ 10^{15} - 10^{17} cm^{-2}, rotational temperatures T_{rot}(CO) ~ 300 - 700 K, and Doppler b-values, b ~ 0.5 - 1.5 km s^{-1}. We use these results to constrain the line-of-sight density of the warm molecular gas (n_{CO} ~ 70 - 4000 cm^{-3}) and put these observations in context with protoplanetary disk models.Comment: 12 pages, 14 figures, ApJ - accepte

Implications of solar flare hard X-ray "knee" spectra observed by RHESSI

We analyse the RHESSI photon spectra of four flares that exhibit significant deviations from power laws - i.e. changes in the "local" Hard X-ray spectral index. These spectra are characterised by two regions of constant power law index connected by a region of changing spectral index - the "knee". We develop theoretical and numerical methods of describing such knees in terms of variable photon spectral indices and we study the results of their inversions for source mean thin target and collisional thick target injection electron spectra. We show that a particularly sharp knee can produce unphysical negative values in the electron spectra, and we derive inequalities that can be used to test for this without the need for an inversion to be performed. Such unphysical features would indicate that source model assumptions were being violated, particularly strongly for the collisional thick target model which assumes a specific form for electron energy loss. For all four flares considered here we find that the knees do not correspond to unphysical electron spectra. In the three flares that have downward knees we conclude that the knee can be explained in terms of transport effects through a region of non-uniform ionisation. In the other flare, which has an upward knee, we conclude that it is most likely a feature of the accelerated spectrum

Investigation of mixed element hybrid grid-based CFD methods for rotorcraft flow analysis

Accurate first-principles flow prediction is essential to the design and development of rotorcraft, and while current numerical analysis tools can, in theory, model the complete flow field, in practice the accuracy of these tools is limited by various inherent numerical deficiencies. An approach that combines the first-principles physical modeling capability of CFD schemes with the vortex preservation capabilities of Lagrangian vortex methods has been developed recently that controls the numerical diffusion of the rotor wake in a grid-based solver by employing a vorticity-velocity, rather than primitive variable, formulation. Coupling strategies, including variable exchange protocols are evaluated using several unstructured, structured, and Cartesian-grid Reynolds Averaged Navier-Stokes (RANS)/Euler CFD solvers. Results obtained with the hybrid grid-based solvers illustrate the capability of this hybrid method to resolve vortex-dominated flow fields with lower cell counts than pure RANS/Euler methods

Evaluation of the cutaneous microbiome in psoriasis

Psoriasis, a highly prevalent disease of humans of unknown cause, is a chronic inflammatory disorder primarily involving skin, with distinctive clinical characteristics. With the newly developed tools that facilitate microbiome research, it now is possible to assess whether the cutaneous microbiome plays a role in the pathogenesis of this disorder. Preliminary data from our studies suggest that the cutaneous microbiome in psoriasis is complex and possibly different from normal. To deal with this complexity, we propose to examine the cutaneous microbiome in relation to psoriasis with explorations at several taxonomic and informatic levels. Our overall objective is to examine how changes in the normal cutaneous microbiome contributes to the pathogenesis of psoriasis. Since causality is complex and often difficult to prove, our overall hypothesis is that there are alterations in the cutaneous microbiome in areas of skin affected by psoriasis in comparison with the range observed in clinically unaffected areas, or in healthy persons. We also hypothesize that the characteristics of the microbiome may affect clinical responses to the immunomodulatory agents used to treat psoriasis. An alternative hypothesis is that effective treatment of psoriasis with systemic immunomodulatory agents will not substantially affect the disordered microbial ecosystem. Such observations would provide evidence for the roles of the microbiota in this disorder. Since an important consideration in microbiome research is the optimal level (e.g. phylum, genus, species, strain, gene) at which to examine a scientific question, and we are not yet certain what are the optimal levels for psoriasis, this also will be examined. Our studies of psoriasis should allow development of both approaches and tools that will have general utility for microbiome research. To test our hypothesis, we propose the following specific aims: 1. To understand the cutaneous microbiome species composition overlaying psoriatic lesions; 2. To investigate differences in metagenome content for psoriatic lesions compared to normal skin; 3. To identify differences in the transcriptional profiles of the microbiome and the host between normal skin and psoriatic lesions using high-throughput sequencing; and 4. To estimate the effects of systemic immunomodulatory therapy for psoriasis on microbiome composition. In total, these studies should help us understand the role of the microbiome in psoriasis pathogenesis

Qualification of low drift single-use pH sensors for use in single-use bioreactor platforms

The biopharmaceutical industry is currently limited by access to low drift, gamma stable, easy-to-integrate single-use pH sensors for application in single-use bioreactors (S.U.B.). Hamilton Company has developed the OneFerm VP 70 sensor, a unique single-use glass electrode, which provides an additional option for customers wishing to implement reliable single-use pH sensing capabilities in the S.U.B. platform. In order to demonstrate the efficacy of these devices, a series of qualification experiments were carried out using a Thermo Fisher Scientific 50L bioprocess container (BPC) custom-fitted with Hamilton OneFerm sensors. BPCs were manufactured in a cGMP facility and allowed to age for a pre-established period (either 30 or 180 days). A 14 day fed-batch cell run was executed using an in-house CHO-S cell line (mAb producing clone) and standard operating conditions. Online pH was controlled with a Hamilton EasyFerm pH sensor; reactor pH was controlled using CO2 without acid or base. Each BPC was built with 6 OneFerm sensors (containing 2 each from 3 different production lots), which were monitored using stand-alone transmitters. Offline samples were evaluated every 24 hours using an Oakton pH sensor. The results from the initial 30 day aged BPC evaluation demonstrate functional activity of the OneFerm sensors over a 14 day fed-batch cell run using a TruBio DeltaV S.U.B. controller. Functional stability of these sensors was demonstrated by maintaining the devices in sterile culture conditions for a period of 60 days; 5 out of 6 sensors met all manufacturers’ specifications during this hold period. To determine if BPC storage time contributes to loss in sensor functionality, a 14 day fed-batch cell run was repeated using a 180 day aged BPC. All 6 OneFerm sensors met manufacturer’s specifications after the cell run with no sensor exhibiting a gross pH drift greater than 0.11 during the entire 14 day period. Additionally, all 6 sensors also met manufacturer’s specifications during the 60 day hold period with no sensor exhibiting an average gross pH drift greater than 0.15 during this extended time. Furthermore, all sensors demonstrated an average response time of less than 10 seconds following the 60 day hold period. The results of these experiments demonstrate the effectiveness of Hamilton OneFerm sensors in the Thermo Fisher Scientific HyPerforma S.U.B. platform. Thermo Fisher Scientific has since developed a custom polycarbonate probe port adapter to robustly integrate the OneFerm sensor in a S.U.B. BPC. Future work will continue to evaluate the performance of sensors aged in BPCs for 24 to 36 months. We are excited to share this growing body of data with the bioprocess industry as probe drift, ionic strength sensitivity, and shelf life have greatly limited implementation of SU pH over the past decade. These results appear to indicate a viable technology is now available and is suitable for cGMP bio manufacturing

A short diastereoselective total synthesis of (±)-vibralactone

A total synthesis of the (±)-vibralactone has been achieved in 11 steps and 16% overall yield from malonic acid. Key steps include a highly diastereoselective allylation of an α-formyl ester containing an all carbon α-quaternary center, a Pd-catalyzed deallylative β-lactonization, and an aldehyde-selective Wacker oxidation of a terminal alkene