Different characteristics of triptans

Despite the pharmacokinetic differences among triptans and the variety of ways of administration, the clinical differences in everyday use of these drugs do not allow a largely accepted decisional tree. There are a number of comparative trials showing similar results with regard to efficacy, safety, and tolerability of these drugs. This means that the patientrsquos preference is one of the most important decisive factors in choosing one triptan over another. A good migraine therapy requires a balance between patient satisfaction and drug efficacy and safety. All the marked triptans show a good benefit-risk ratio, and comorbidity should be considered when choosing between different triptans

Topo-kinesthetic memory in chronic headaches. A new test for chronic patients: preliminary report

The objective of this study was to establish if chronic headaches with medication overuse can modify a topo\u2013kinesthetic memory test. Nineteen patients with medication overuse headache (MOH), 13 patients with chronic tension\u2013type headache (CTTH) without medication use and a group of "normal" subjects underwent a topo\u2013kinesthetic memory test at T0 and after one month (T1); a control group of healthy volunteers was also tested to establish the baseline in our experimental setting. After one month, in the MOH patients there was a reduction of medication overuse from 3.3\ub12.65 to 1.1\ub12.23 (p<0.01), but no significant reduction in headache frequency and severity index, quality of life, anxiety and depression scores. The navigation time at T0 was 14.3\ub14.97, 27.9\ub110.12, 34.3\ub115.38 and 7.5\ub12.33, 10.1\ub12.95, 11.4\ub13.21 for control, MOH and CTTH with closed and open eyes, respectively (p<0.02). At T1, the MOH patients reached performances with open eyes similar to the healthy controls, while with closed eyes the navigation test reached times similar to those of CTTH patients. The topokinesthetic memory test seems both able to discriminate MOH and CTTH from healthy volunteers and to be related to pain scores but is not influenced by the use of drugs

Homocysteine levels and cardiovascular disease in migraine with aura

Clinical studies suggest that hyperhomocysteinemia could be considered an independent risk factor for premature cerebral, peripheral and vascular diseases. A number of authors found an epidemiological correlation between increased risk of cerebrovascular disease and migraine with aura. In this study, 34 patients suffering from migraine with aura and 36 healthy controls were evaluated with respect to total plasma homocysteine levels, measured with FPIA immunoassay in the fasting state and after methionine load. Moreover, vitamin B12, folate and other classic biochemical indicators of atherosclerosis disease were evaluated. In this study, homocysteine levels, both at basal and after load, and other cardiovascular risk factors such as vitamin B12 and apo-LpA were within the normal range. Other multicentric randomised trials are needed to carry on and confirm these data

Consumo de noticias vía redes sociales en el contexto de pandemia del COVID-19 en Argentina

Fil: Brovia, Fernanda D.. Universidad de San Andrés. Departamento de Ciencias Sociales; Argentina

Risk–benefit and cost–benefit ratio in headache treatment

The cost\u2013benefit and the risk\u2013benefit ratios are two of the most relevant items in ongoing health organisation procedures. The choice of a new or an old therapeutic treatment depends on a number of factors and the evaluation of the cost, in terms of economics, but also in terms of quality of life and type of facilities necessary for one treatment are crucial criteria. Therefore, we have to consider in evaluating treatment strategies not only the activity of a drug in reaching the main end\u2013points, (i.e., pain free or headache relief) but also the safety and perception of safety by patients, and the cost effectiveness, including indirect costs compared with personal and social benefits. Because it is reasonable that a subgroup of migraine patients may have a clinically progressive disorder, studies should be necessary to assess strategies for migraine treatments

Analysis of three-year activity of an information service on doping

A total of 2980 calls had been made at the end of 2004. Typology of users: amateur athletes 78%; professional athletes 6%, people not involved in sport activity 16%. The sport most practiced was cycling 62%. Typology of calls by substances was the following: integrators of creatina 65%; anabolic stroids 15%; integrators of guaranà, ginseng, caffeine 7%; darbepoietin alpha 6%; beta adrenergic agonists 4%; probenecid 3%