A new observational and numerical study of tidal interactions in M81-M82-NGC3077 system

A nearby system of interacting galaxies M81-M82-NGC3077 triplet (D = 3.3 Mpc; Freeman & Madore 1988) has been studied using multi-wavelength observations and numerical simulations to obtain a comprehensive understanding on the dynamics and the consequences of tidal interactions in a group environment. The VLA 12-field Mosaic H I observations of 2 x 1.5 deg. region have revealed a vast array of H I filaments which suggests that the severity and extent of tidal disruptions far exceed the previous estimates. A tidal remnant of the former H I disk of M82 extending up to 30 kpc (in projection) is identified for the first time, and the pervasive effects of the tidal disruption are traced into the inner disk by optical and CO observations, including a kinematic trace of a large scale bar potential (Yun, Ho, & Lo 1992). The H I disk of M81 is traced out to 40 kpc in radius, and a large scale (l approx. 20 kpc) velocity anomaly ('High Velocity Trough'), which may be a remnant of a gaseous collision, is found within the disk of M81. The large H I bridge between M81 and NGC 3077 (van der Hulst 1979) is also found to extend approx. greater than 50 kpc further, bending around NGC 3077, toward M82. The total H I detected in this experiment, 5.6 x 10(exp 9) solar mass, represents the majority of the single-dish flux (Appleton, Davies, & Stephenson 1981) and suggests that the bulk of H I found in the region belongs to the three galaxies and the tidal filaments. The impact and details of the tidal interactions have been further examined through the use of numerical techniques. The 'restricted 3-body' approach was used to simulate the observed distribution of tidal H I streamers connecting the three galaxies, and the success of the simulation is further strengthened by the accurate predictions on the gas kinematics

Gemini Spectroscopy and HST Imaging of the Stellar Cluster Population in Region B of M82

We present new spectroscopic observations of the stellar cluster population of region B in the prototype starburst galaxy M82 obtained with the Gillett Gemini-North 8.1-metre telescope. By coupling the spectroscopy with UBVI photometry acquired with the Advanced Camera for Surveys (ACS) on the Hubble Space Telescope (HST), we derive ages, extinctions and radial velocities for seven young massive clusters (YMCs) in region B. We find the clusters to have ages between 70 and 200 Myr and velocities in the range 230 to 350 km/s, while extinctions Av vary between ~1-2.5 mag. We also find evidence of differential extinction across the faces of some clusters which hinders the photometric determination of ages and extinctions in these cases. The cluster radial velocities indicate that the clusters are located at different depths within the disk, and are on regular disk orbits. Our results overall contradict the findings of previous studies, where region B was thought to be a bound region populated by intermediate-age clusters that formed in an independent, offset starburst episode that commenced 600 Myr-1 Gyr ago. Our findings instead suggest that region B is optically bright because of low extinction patches, and this allows us to view the cluster population of the inner M82 disk, which probably formed as a result of the last encounter with M81. This study forms part of a series of papers aimed at studying the cluster population of M82 using deep optical spectroscopy and multi-band photometry.Comment: 12 pages, 8 figures; accepted for publication in The Astrophysical Journa

Role of EG-VEGF in Human Placentation: Physiological and Pathological Implications

International audienc

Relations between cognition and motricity in children with neonatal arterial ischemic stroke

Introduction and goalPerinatal arterial ischemic stroke (PAIS) affects one child for 4000 births. The few studies about cognitive development specific to PAIS showed that cognitive performances in this population do not follow up a normal development (Westmacott et al., 2010; Ricci et al., 2008). Based on new data about relation between motricity and cognition (Smits-Engelsman et Hill, 2012), and on the theory of the embodied cognition, led us to hypothesize that cognitive performances would be correlated to the motor performances in children with PAIS.Patients and methodologyWe tested 77 7 years old children meeting the criteria of neonatal AIS, with a diagnosis before the 28th day of life relying on cerebral imagery. After excluding children with seizure and bi-hemispheric lesion, 56 children participated to our study. The cognitive evaluation was performed with the Wechsler Intelligence Scale for Children (WISC-4), the motor evaluation relied on testing of gross motor of the upper arm (Box and Block Test) and fine prehension test (“Nine Hole Peg Test”). The localisation of the lesion, the economic level of parents, the gender, sensory impairments and the presence of hemiplegia were collected. We analyzed these results with simple linear regression.ResultsThe main result of our study is the significative correlation (P<0.03) between scores of the WISC4 (except for working memory index) and motor results. In contrast we did not find any correlation between the scores of the WISC4 and the presence of hemiplegia or with lesion localization.DiscussionMany brain networks develop during the first year through sensorimotor experiences, which contribute to the emergence of knowledge. This concept of development, supported by the approach embodied cognition, can explain the correlations between cognition and motor found in our work and in several studies with children with other early neurological damage

Widespread HCO emission in the M82's nuclear starburst

We present a high-resolution (~ 5'') image of the nucleus of M82 showing the presence of widespread emission of the formyl radical (HCO). The HCO map, the first obtained in an external galaxy, reveals the existence of a structured disk of ~ 650 pc full diameter. The HCO distribution in the plane mimics the ring morphology displayed by other molecular/ionized gas tracers in M82. More precisely, rings traced by HCO, CO and HII regions are nested, with the HCO ring lying in the outer edge of the molecular torus. Observations of HCO in galactic clouds indicate that the abundance of HCO is strongly enhanced in the interfaces between the ionized and molecular gas. The surprisingly high overall abundance of HCO measured in M82 (X(HCO) ~ 4x10^{-10}) indicates that its nuclear disk can be viewed as a giant Photon Dominated Region (PDR) of ~ 650 pc size. The existence of various nested gas rings, with the highest HCO abundance occurring at the outer ring (X(HCO) ~ 0.8x10^{-9}), suggests that PDR chemistry is propagating in the disk. We discuss the inferred large abundances of HCO in M82 in the context of a starburst evolutionary scenario, picturing the M82 nucleus as an evolved starburst.Comment: 13 pages, 3 figures, to appear in ApJ Letters; corrected list of author

Effect of host species on the topography of fitness landscape for a plant RNA virus

[EN] Adaptive fitness landscapes are a fundamental concept in evolutionary biology that relate the genotype of individuals with their fitness. At the end, the evolutionary fate of evolving populations depends on the topography of the landscape, that is, the number of accessible mutational pathways and of possible fitness peaks (i.e, adaptive solutions). For long time, fitness landscapes were only theoretical constructions due to a lack of precise information on the mapping between genotypes and phenotypes. In recent years, however, efforts have been devoted to characterize the properties of empirical fitness landscapes for individual proteins or for microbes adapting to artificial environments. In a previous study, we had characterized the properties of the empirical fitness landscape defined by the first five mutations fixed during adaptation of tobacco etch potyvirus (TEV) to a new experimental host, Arabidopsis thaliana. Here we evaluate the topography of this landscape in the ancestral host Nicotiana tabacum. Comparing the topographies of the landscape in the two hosts, we found that some features remain similar, such as the existence of fitness holes and the prevalence of epistasis, including cases of sign and of reciprocal sign that create rugged, uncorrelated and highly random topographies. However, we also observed significant differences in the fine grained details among both landscapes due to changes in the fitness and epistatic interactions of some genotypes. Our results support the idea that not only fitness tradeoffs between hosts but also topographical incongruences among fitness landscapes in alternative hosts may contribute to virus specialization.This project was funded by grants BFU2012-30805 and BFU2015-65037P from the Spanish Ministry of Economy and Competitiveness (MINECO), PROMETEOII/2014/021 from the Generalitat Valenciana, and EvoEvo (ICT610427) from the European Commission 7th Framework Program to S.F.E. H.C. was supported by contract BES2013-065595 from MINECO. J.L. was supported by a JAE-pre contract from CSIC.Cervera-Benet, H.; Lalic, J.; Elena Fito, SF. (2016). Effect of host species on the topography of fitness landscape for a plant RNA virus. Journal of Virology. 90(22):10160-10169. https://doi.org/10.1128/JVI.01243-16S1016010169902

Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin.

Huntington's disease, an inherited neurodegenerative disorder, results from abnormal polyglutamine extension in the N-terminal region of the huntingtin protein. This mutation causes preferential degeneration of striatal projection neurons. We previously demonstrated, in vitro, that dopaminergic D2 receptor stimulation acted in synergy with expanded huntingtin to increase aggregates formation and striatal death through activation of the Rho/ROCK signaling pathway. In vivo, in a lentiviral-mediated model of expanded huntingtin expression in the rat striatum, we found that the D2 antagonist haloperidol protects striatal neurons against expanded huntingtin-mediated toxicity. Two variant transcripts are generated by alternative splicing of the of D2 receptor gene, the D2R-Long and the D2R-Short, which are thought to play different functional roles. We show herein that overexpression of D2R-Short, but not D2R-Long in cell lines is associated with activation of the RhoA/ROCK signaling pathway. In striatal neurons in culture, the selective D2 agonist Quinpirole triggers phosphorylation of cofilin, a downstream effector of ROCK, which is abrogated by siRNAs that knockdown both D2R-Long and D2R-Short, but not by siRNAs targeting D2R-Long alone. Aggregate formation and neuronal death induced by expanded huntingtin, were potentiated by Quinpirole. This D2 agonist-mediated effect was selectively inhibited by the siRNA targeting both D2R-Long and D2R-Short but not D2R-Long alone. Our data provide evidence for a specific coupling of D2R-Short to the RhoA/ROCK/cofilin pathway, and its involvement in striatal vulnerability to expanded huntingtin. A new route for targeting Rho-ROCK signaling in Huntington's disease is unraveled with our findings

A spectroscopic census of the M82 stellar cluster population

We present a spectroscopic study of the stellar cluster population of M82, the archetype starburst galaxy, based primarily on new Gemini-North multi-object spectroscopy of 49 star clusters. These observations constitute the largest to date spectroscopic dataset of extragalactic young clusters, giving virtually continuous coverage across the galaxy; we use these data to deduce information about the clusters as well as the M82 post-starburst disk and nuclear starburst environments. Spectroscopic age-dating places clusters in the nucleus and disk between (7, 15) and (30, 270) Myr, with distribution peaks at ~10 and ~140 Myr respectively. We find cluster radial velocities in the range (-160, 220) km/s (wrt the galaxy centre) and line of sight Na I D interstellar absorption line velocities in (-75, 200) km/s, in many cases entirely decoupled from the clusters. As the disk cluster radial velocities lie on the flat part of the galaxy rotation curve, we conclude that they comprise a regularly orbiting system. Our observations suggest that the largest part of the population was created as a result of the close encounter with M81 ~220 Myr ago. Clusters in the nucleus are found in solid body rotation on the bar. The possible detection of WR features in their spectra indicates that cluster formation continues in the central starburst zone. We also report the potential discovery of two old populous clusters in the halo of M82, aged >8 Gyr. Using these measurements and simple dynamical considerations, we derive a toy model for the invisible physical structure of the galaxy, and confirm the existence of two dominant spiral arms.Comment: Accepted for publication in the Astrophysical Journa

Tracing high density gas in M 82 and NGC 4038

We present the first detection of CS in the Antennae galaxies towards the NGC 4038 nucleus, as well as the first detections of two high-J (5-4 and 7-6) CS lines in the center of M 82. The CS(7-6) line in M 82 shows a profile that is surprisingly different to those of other low-J CS transitions we observed. This implies the presence of a separate, denser and warmer molecular gas component. The derived physical properties and the likely location of the CS(7-6) emission suggests an association with the supershell in the centre of M 82.Comment: 10 pages, 3 figures, ApJ Letter - ACCEPTE

Manual dexterity, but not cerebral palsy, predicts cognitive functioning after neonatal stroke

AIM: To disentangle the respective impacts of manual dexterity and cerebral palsy (CP) in cognitive functioning after neonatal arterial ischaemic stroke. METHOD: The population included 60 children (21 females, 39 males) with neonatal arterial ischaemic stroke but not epilepsy. The presence of CP was assessed clinically at the age of 7 years and 2 months (range 6y 11mo-7y 8mo) using the definition of the Surveillance of CP in Europe network. Standardized tests (Nine-Hole Peg Test and Box and Blocks Test) were used to quantify manual (finger and hand respectively) dexterity. General cognitive functioning was evaluated with the Wechsler Intelligence Scale for Children, Fourth Edition. Simple and multiple linear regression models were performed while controlling for socio-economic status, lesion side, and sex. RESULTS: Fifteen children were diagnosed with CP. In simple regression models, both manual dexterity and CP were associated with cognitive functioning (β=0.41 [p=0.002] and β=0.31 [p=0.019] respectively). However, in multiple regression models, manual dexterity was the only associated variable of cognitive functioning, whether or not a child had CP (β=0.35; p=0.007). This result was reproduced in models with other covariables (β=0.31; p=0.017). INTERPRETATION: As observed in typically developing children, manual dexterity is related to cognitive functioning in children having suffered a focal brain insult during the neonatal period. WHAT THIS PAPER ADDS: Manual dexterity predicts cognitive functioning after neonatal arterial ischaemic stroke. Correlations between manual dexterity and cognitive functioning occur irrespective of sex, lesion side, presence of cerebral palsy, and socio-economic status. Residual motor ability may support cognitive functioning